Zuogui Wan alleviated maternal kidney-yin deficiency-induced thymic epithelial cell dysfunction in newborn rats through Wnt/β-catenin signaling pathway.

Chen L, Ren M, Cao J, Sang H, Chen H, Xu A, Zhao M

Journal of ethnopharmacology17 Jun 2021Cited by 6 (Europe PMC)

PMID34146629DOI10.1016/j.jep.2021.114337PepBankPUB-34146629

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Natural levels measured4

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

01AnimalEndogenous levelAnimal study (in vivo)Other
In rats with maternal kidney-yin deficiency, thymic TMSβ4 levels were decreased.
In plain wordsIn rats with kidney-yin deficiency, the body's own TMSβ4 levels in the thymus were lower.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseThymic TMSβ4 level in kidney-yin deficiency rats
Study
ratn: not reported in source
kidney-yin deficiency (KYD) rats
Comparator
Vehicle rats
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Meanwhile, the decreased TMSβ4, Tα1, Wnt4, β-catenin, and Foxn1 levels in KYD rats were also significantly alleviated by ZGW administration.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were randomly assigned to four groups (n = 8).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3414662901
02AnimalEndogenous levelAnimal study (in vivo)Other
In rats with kidney-yin deficiency, Zuogui Wan administration significantly alleviated the decrease in TMSβ4 levels.
In plain wordsIn rats with kidney-yin deficiency, the herbal medicine Zuogui Wan reduced the drop in the body's own TMSβ4 levels.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseThymic TMSβ4 level after Zuogui Wan in kidney-yin deficiency rats
Study
ratn: not reported in source
kidney-yin deficiency (KYD) rats
Comparator
Untreated KYD rats
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
Meanwhile, the decreased TMSβ4, Tα1, Wnt4, β-catenin, and Foxn1 levels in KYD rats were also significantly alleviated by ZGW administration.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were randomly assigned to four groups (n = 8).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3414662902
03LabEndogenous levelIn vitro (cells)Other
In thymic epithelial cells from newborn rats, Zuogui Wan intervention elevated TMSβ4 levels.
In plain wordsIn rat thymus cells, the herbal medicine Zuogui Wan raised the body's own TMSβ4 levels.
Peptide
Thymosin beta-4 (human)
Outcome
IncreaseTMSβ4 level in thymic epithelial cells after Zuogui Wan
Study
ratn: not reported in source
thymic epithelial cells from newborn rats of KYD mothers
Comparator
Cells without Zuogui Wan
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
In vitro, elevated TMSβ4 and Tα1 levels accompanied with upregulated Wnt4, β-catenin, and Foxn1 expressions in the TECs were observed after ZGW intervention, however, which were significantly downregulated by ICG-001 supplement.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were randomly assigned to four groups (n = 8).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3414662903
04LabEndogenous levelIn vitro (cells)Other
In thymic epithelial cells, the Zuogui Wan-induced rise in TMSβ4 levels was significantly downregulated by the Wnt pathway inhibitor ICG-001.
In plain wordsIn rat thymus cells, a Wnt pathway blocker cancelled the rise in the body's own TMSβ4 caused by Zuogui Wan.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseTMSβ4 level in thymic epithelial cells with ICG-001
Study
ratn: not reported in source
thymic epithelial cells from newborn rats of KYD mothers
Comparator
Zuogui Wan without ICG-001
Outcome group
Immune response · Immune and inflammation
Source sentences
Summary
In vitro, elevated TMSβ4 and Tα1 levels accompanied with upregulated Wnt4, β-catenin, and Foxn1 expressions in the TECs were observed after ZGW intervention, however, which were significantly downregulated by ICG-001 supplement.
1 context sentence(design, population, supporting numbers)
Summary · context
Rats were randomly assigned to four groups (n = 8).
This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3414662904

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 4Current
13 Oct 2026, 01:52 UTC
Study results updated
Versions 2 to 3
12 Oct 2026, 18:17 UTC
The same notice was added 2 times, first on 9 Oct 2026, 03:03 UTC. The status did not change between them.
Study data updated · source update from Europe PMC
Version 1
9 Oct 2026, 03:02 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.