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Study · Measured the body's own peptide · 2021

5 results

Level of kisspeptin-10 in patients with multiple sclerosis and the association between third ventricle diameter size and vitamin D level.

Akdag T, Uca AU, Altas M, Odabas FO, Aktas F

Physiology international16 Jun 2021Cited by 1 (Europe PMC)

PMID34138749 (opens in a new tab)DOI10.1556/2060.2021.00179 (opens in a new tab)PepBankPUB-34138749
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

No result from this study comes from a test of the peptide.

Natural levels measured5

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyMechanism

    Serum kisspeptin‑10 was significantly lower in patients with relapsing-remitting multiple sclerosis than in healthy controls.

    In plain wordsPeople with multiple sclerosis had lower levels of the body's own kisspeptin‑10 in blood than healthy people.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSerum kisspeptin-10 in multiple sclerosis
    Study

    n = 92

    Comparator
    Healthy controls
    Outcome group
    Sex hormones and fertility · Nervous system and cognition

    Measurements

    Serum kisspeptin-10
    2.305 ng/mL
    MS patients
    Serum kisspeptin-10
    9.342 ng/mL
    healthy controls

    Source sentences

    Summary
    The level of kisspeptin-10 was measured as 2.305 ± 2.781 ng/mL in MS patients and 9.342 ± 9.483 ng/mL in controls. MS patients had significantly lower kisspeptin-10 levels than controls (P = 0.000).
    1 context sentence
    Summary · context
    A total of 92 participants, 46 patients with relapsing-remitting MS (mean age, 38.92 ± 14.76; 22 men and 24 women) and 46 healthy controls (mean age, 37.04 ± 15.49; 22 men and 24 women) were enrolled in the study.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    Serum kisspeptin‑10 level had diagnostic value for multiple sclerosis, with an area under the curve of 0.881.

    In plain wordsIn this study, the body's own kisspeptin‑10 level in blood separated people with multiple sclerosis from healthy people fairly well.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableDiagnostic value of serum kisspeptin-10 for MS
    Study

    n = 92

    Comparator
    Healthy controls
    Outcome group
    Aging markers · Nervous system and cognition

    Measurements

    AUC
    0.881
    MS vs controls
    Sensitivity
    80.4%
    cut-off 2.470
    Specificity
    72.87%
    cut-off 2.470

    Source sentences

    Summary
    Kisspeptin-10 has the highest diagnostic value [Area under curve (AUC) = 0.881, 95% confidence interval (CI), 0.812-0.950] as cut-off value (2.470), sensitivity (80.40%) and specificity (72.87%) in the MS group.
    1 context sentence
    Summary · context
    A total of 92 participants, 46 patients with relapsing-remitting MS (mean age, 38.92 ± 14.76; 22 men and 24 women) and 46 healthy controls (mean age, 37.04 ± 15.49; 22 men and 24 women) were enrolled in the study.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 03HumanEndogenous levelObservational studyMechanism

    In patients with multiple sclerosis, serum kisspeptin‑10 was negatively correlated with third ventricle diameter.

    In plain wordsIn people with multiple sclerosis, lower levels of the body's own kisspeptin‑10 were linked to a larger third ventricle in the brain.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKisspeptin-10 correlation with third ventricle diameter
    Study

    n = 46

    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    Furthermore, the kisspeptin-10 level was negatively correlated with third ventricle diameter (TVD) (P = 0.048) and vitamin D concentration (P = 0.004).
    1 context sentence
    Summary · context
    A total of 92 participants, 46 patients with relapsing-remitting MS (mean age, 38.92 ± 14.76; 22 men and 24 women) and 46 healthy controls (mean age, 37.04 ± 15.49; 22 men and 24 women) were enrolled in the study.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  4. 04HumanEndogenous levelObservational studyMechanism

    In patients with multiple sclerosis, serum kisspeptin‑10 did not differ significantly by other clinical parameters.

    In plain wordsIn people with multiple sclerosis, the body's own kisspeptin‑10 level was not linked to other clinical measures.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeKisspeptin-10 and other clinical parameters
    Study

    n = 46

    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    No significant difference was determined between kisspeptin-10 and other clinical parameters.
    1 context sentence
    Summary · context
    A total of 92 participants, 46 patients with relapsing-remitting MS (mean age, 38.92 ± 14.76; 22 men and 24 women) and 46 healthy controls (mean age, 37.04 ± 15.49; 22 men and 24 women) were enrolled in the study.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  5. 05HumanEndogenous levelObservational studyMechanism

    Serum kisspeptin‑10 was negatively correlated with vitamin D concentration.

    In plain wordsLower levels of the body's own kisspeptin‑10 were linked to higher vitamin D levels.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseKisspeptin-10 correlation with vitamin D concentration
    Study

    n: not reported in source

    Outcome group
    Aging markers · Nervous system and cognition

    Source sentences

    Summary
    Furthermore, the kisspeptin-10 level was negatively correlated with third ventricle diameter (TVD) (P = 0.048) and vitamin D concentration (P = 0.004).
    1 context sentence
    Summary · context
    A total of 92 participants, 46 patients with relapsing-remitting MS (mean age, 38.92 ± 14.76; 22 men and 24 women) and 46 healthy controls (mean age, 37.04 ± 15.49; 22 men and 24 women) were enrolled in the study.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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