[Gly14]-Humanin Ameliorates High Glucose-Induced Apoptosis by Inhibiting the Expression of MicroRNA-155 in Endothelial Microparticles.

Shen MY, Wang M, Liu Z, Wang S, Xie Y

Diabetes, metabolic syndrome and obesity : targets and therapy24 May 2021Cited by 4 (Europe PMC)

PMID34079312PMCIDPMC8163639DOI10.2147/dmso.s306026PepBankPUB-34079312

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Mechanism
In HUVECs, HNG pretreatment mitigated the high-glucose-induced increase in the number of endothelial microparticles.
In plain wordsIn cells, HNG pretreatment reduced the rise in endothelial microparticle numbers caused by high glucose.
Peptide
Humanin
Outcome
DecreaseNumber of endothelial microparticles under high glucose
Study
humann: not reported in source
Human umbilical vein endothelial cells (HUVECs)
Comparator
High glucose without HNG pretreatment
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
We found that high glucose (HG) increased the number of EMPs and upregulated the expression of miR-155 contained within EMPs, which was mitigated by HNG pretreatment.
1 context sentence(design, population, supporting numbers)
Summary · context
EMPs were isolated from human umbilical vein endothelial cells (HUVECs) by ultracentrifugation.
Report a problemFND-3407931201
02LabIn vitro (cells)Mechanism
In HUVECs, HNG pretreatment mitigated the high-glucose-induced upregulation of miR-155 in endothelial microparticles.
In plain wordsIn cells, HNG pretreatment reduced the high-glucose-driven rise of miR-155 in endothelial microparticles.
Peptide
Humanin
Outcome
DecreasemiR-155 expression in endothelial microparticles under high glucose
Study
humann: not reported in source
Human umbilical vein endothelial cells (HUVECs)
Comparator
High glucose without HNG pretreatment
Outcome group
Vascular function · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
We found that high glucose (HG) increased the number of EMPs and upregulated the expression of miR-155 contained within EMPs, which was mitigated by HNG pretreatment.
1 context sentence(design, population, supporting numbers)
Summary · context
EMPs were isolated from human umbilical vein endothelial cells (HUVECs) by ultracentrifugation.
Report a problemFND-3407931202
03LabIn vitro (cells)Efficacy outcome
In endothelial cells exposed to high glucose, HNG inhibited apoptosis.
In plain wordsIn cells, HNG reduced the cell death caused by high glucose.
Peptide
Humanin
Outcome
DecreaseHigh-glucose-induced apoptosis of endothelial cells
Study
humann: not reported in source
Human umbilical vein endothelial cells (HUVECs)
Comparator
High glucose without HNG
Outcome group
Cell viability and death · Cardiovascular
Studied dose
Dose not stated
Source sentences
Summary
HNG inhibited HG-induced apoptosis of ECs
1 context sentence(design, population, supporting numbers)
Summary · context
EMPs were isolated from human umbilical vein endothelial cells (HUVECs) by ultracentrifugation.
Report a problemFND-3407931203

Studies that did not test the peptide alone3

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

04LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In HUVECs, miR-155 overexpression in endothelial microparticles reversed the effects of HNG pretreatment and increased apoptosis of target cells.
In plain wordsIn cells, raising miR-155 in microparticles undid the effect of HNG and increased cell death.
Peptide
Humanin
Outcome
IncreaseApoptosis of target cells after miR-155 overexpression in microparticles
Study
humann: not reported in source
Human umbilical vein endothelial cells (HUVECs)
Comparator
HNG pretreatment without miR-155 overexpression
Outcome group
Cell viability and death · Cardiovascular
Source sentences
Summary
miR-155 overexpression in EMPs reversed the effects of HNG pretreatment and increased apoptosis of target cells.
1 context sentence(design, population, supporting numbers)
Summary · context
EMPs were isolated from human umbilical vein endothelial cells (HUVECs) by ultracentrifugation.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3407931204
05LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In HUVECs, miR-155 mimic transfection mitigated the effects of HNG pretreatment on high-glucose-treated endothelial cells.
In plain wordsIn cells, adding a miR-155 mimic weakened the effects of HNG on cells exposed to high glucose.
Peptide
Humanin
Outcome
DecreaseHNG effect on high-glucose-treated endothelial cells after miR-155 mimic
Study
humann: not reported in source
Human umbilical vein endothelial cells (HUVECs)
Comparator
HNG pretreatment without miR-155 mimic
Outcome group
Cell viability and death · Cardiovascular
Source sentences
Summary
Effects of HNG pretreatment on HG-treated endothelial cells (ECs) were mitigated after miR-155 mimic transfection into HUVECs while were augmented after miR-155 inhibitor transfection into HUVECs.
1 context sentence(design, population, supporting numbers)
Summary · context
EMPs were isolated from human umbilical vein endothelial cells (HUVECs) by ultracentrifugation.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3407931205
06LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In HUVECs, miR-155 inhibitor transfection augmented the effects of HNG pretreatment on high-glucose-treated endothelial cells.
In plain wordsIn cells, adding a miR-155 inhibitor strengthened the effects of HNG on cells exposed to high glucose.
Peptide
Humanin
Outcome
IncreaseHNG effect on high-glucose-treated endothelial cells after miR-155 inhibitor
Study
humann: not reported in source
Human umbilical vein endothelial cells (HUVECs)
Comparator
HNG pretreatment without miR-155 inhibitor
Outcome group
Cell viability and death · Cardiovascular
Source sentences
Summary
Effects of HNG pretreatment on HG-treated endothelial cells (ECs) were mitigated after miR-155 mimic transfection into HUVECs while were augmented after miR-155 inhibitor transfection into HUVECs.
1 context sentence(design, population, supporting numbers)
Summary · context
EMPs were isolated from human umbilical vein endothelial cells (HUVECs) by ultracentrifugation.
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3407931206

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

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