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Study · In vitro (cells) · cattle · 2021

2 results

Kisspeptin-10 Maintains the Activation of the mTOR Signaling Pathway by Inhibiting SIRT6 to Promote the Synthesis of Milk in Bovine Mammary Epithelial Cells.

Cao Y, Hu G, Zhang Q, Ma L, Wang J, Li W, Ge Y, Cheng J, Yang Z, Fu S, Liu J

Journal of agricultural and food chemistry5 Apr 2021Cited by 15 (Europe PMC)

PMID33818062 (opens in a new tab)DOI10.1021/acs.jafc.0c07613 (opens in a new tab)PepBankPUB-33818062
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In bovine mammary epithelial cells, 100 nM Kp-10 increased milk synthesis.

    In plain wordsIn cow mammary cells in the lab, kisspeptin‑10 increased milk production.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseMilk synthesis in BMECs
    Study

    cattlen: not reported in source

    bovine mammary epithelial cells (BMECs)
    Outcome group
    Lactation and milk synthesis · Reproductive and sexual health
    Studied dose
    100 nMAs given in this study (cattle).

    Source sentences

    Summary
    The results showed that 100 nM Kp-10 increased milk synthesis in BMECs.
    1 context sentence
    Summary · context
    Therefore, bovine mammary epithelial cells (BMECs) were used to study the mechanism by which Kp-10 affects milk synthesis in BMECs.

Studies that did not test the peptide alone1

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 02LabNot a test of Kisspeptin-10 aloneIn vitro (cells)Mechanism

    In bovine mammary epithelial cells, overexpression of SIRT6 reversed the Kp-10-induced activation of the mTOR signaling pathway.

    In plain wordsIn cow mammary cells in the lab, raising SIRT6 undid the activation of the mTOR pathway caused by kisspeptin‑10.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSIRT6 overexpression effect on Kp-10-induced mTOR signaling
    Study

    cattlen: not reported in source

    bovine mammary epithelial cells (BMECs)
    Comparator
    Kp-10 alone
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health

    Source sentences

    Summary
    Moreover, overexpression of SIRT6 reversed the activation of the Kp-10-induced mTOR signaling pathway.
    1 context sentence
    Summary · context
    Therefore, bovine mammary epithelial cells (BMECs) were used to study the mechanism by which Kp-10 affects milk synthesis in BMECs.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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