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Study · Animal study (in vivo) · mouse · 2021

3 results

Inhibition of nicotinamide phosphoribosyltransferase protects against acute pancreatitis via modulating macrophage polarization and its related metabolites.

He Y, Dai J, Niu M, Li B, Chen C, Jiang M, Wu Z, Bao J, Zhang X, Li L, Husain SZ, Hu G, Wen L

Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]25 Mar 2021Cited by 17 (Europe PMC)

PMID33810973 (opens in a new tab)DOI10.1016/j.pan.2021.03.011 (opens in a new tab)PepBankPUB-33810973
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN supplementation aggravated caerulein hyperstimulation pancreatitis.

    In plain wordsIn mice, NMN worsened pancreatitis caused by caerulein hyperstimulation.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseCaerulein pancreatitis severity
    Study

    mousen: not reported in source

    Caerulein hyperstimulation pancreatitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN supplementation aggravated caerulein hyperstimulation pancreatitis and alcoholic pancreatitis,
    1 context sentence
    Summary · context
    Acute pancreatitis was induced in mice using three disparate models: (1) caerulein hyperstimulation, (2) ethanol plus palmitoleic acid, and (3) retrograde biliopancreatic ductal infusion of sodium taurocholate. The NAMPT inhibitor FK866 and NAMPT downstream product nicotinamide mononucleotide (NMN) was administered.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, NMN supplementation aggravated alcoholic pancreatitis.

    In plain wordsIn mice, NMN worsened alcoholic pancreatitis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseAlcoholic pancreatitis severity
    Study

    mousen: not reported in source

    Alcoholic pancreatitis
    Outcome group
    Inflammation markers · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, NMN supplementation aggravated caerulein hyperstimulation pancreatitis and alcoholic pancreatitis,
    1 context sentence
    Summary · context
    Acute pancreatitis was induced in mice using three disparate models: (1) caerulein hyperstimulation, (2) ethanol plus palmitoleic acid, and (3) retrograde biliopancreatic ductal infusion of sodium taurocholate. The NAMPT inhibitor FK866 and NAMPT downstream product nicotinamide mononucleotide (NMN) was administered.
  3. 03LabIn vitro (cells)Efficacy outcome

    In cultured mouse macrophages, NMN boosted M1 polarization.

    In plain wordsIn cells from mice, NMN increased M1 macrophage polarization.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseM1 macrophage polarization
    Study

    mousen: not reported in source

    Bone marrow derived macrophages
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NAMPT inhibitor FK866 suppressed M1 macrophage polarization while NMN boosted it.
    1 context sentence
    Summary · context
    Bone marrow derived macrophages were isolated, cultured with cytokines or pancreatic acini, then analyzed by quantitative PCR and non-targeted metabolomics.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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