Skip to content

Study · In vitro (cells) · goat · 2021

7 results

Role of kisspeptin on cell proliferation and steroidogenesis in luteal cells in vitro and in vivo.

Chiang CM, Chiu HY, Chang CS, Chien YY, Jong DS, Wu LS, Chiu CH

Journal of the Chinese Medical Association : JCMA1 Apr 2021Cited by 9 (Europe PMC)

PMID33784266 (opens in a new tab)PMCIDPMC12966175 (opens in a new tab)DOI10.1097/jcma.0000000000000508 (opens in a new tab)PepBankPUB-33784266
Read at sourcePubMedAsk about this study
Jump to 7 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In caprine luteal cells in vitro, Kp-10 reduced progesterone levels.

    In plain wordsIn goat luteal cells in lab tests, kisspeptin‑10 lowered progesterone levels.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseProgesterone (P4) levels
    Study

    goatn: not reported in source

    Temperature-sensitive caprine luteal cell line (ts-CLC-D)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    P value
    < 0.01
    P4 levels

    Source sentences

    Summary
    In vitro, the addition of Kp-10 reduced the P4 levels (p < 0.01) and increased cell proliferation (p < 0.05) of the ts-CLC-D cells.
  2. 02LabIn vitro (cells)Mechanism

    In caprine luteal cells in vitro, Kp-10 increased cell proliferation.

    In plain wordsIn goat luteal cells in lab tests, kisspeptin‑10 increased cell growth.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseCell proliferation
    Study

    goatn: not reported in source

    Temperature-sensitive caprine luteal cell line (ts-CLC-D)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Measurements

    P value
    < 0.05
    cell proliferation

    Source sentences

    Summary
    In vitro, the addition of Kp-10 reduced the P4 levels (p < 0.01) and increased cell proliferation (p < 0.05) of the ts-CLC-D cells.
  3. 03LabIn vitro (cells)Mechanism

    In caprine luteal cells in vitro, Kp-10 significantly decreased STAR protein and mRNA levels.

    In plain wordsIn goat luteal cells in lab tests, kisspeptin‑10 lowered levels of STAR, a hormone-making protein.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseSTAR protein and mRNA
    Study

    goatn: not reported in source

    Temperature-sensitive caprine luteal cell line (ts-CLC-D)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we found that the levels of proteins and mRNA for STAR, CYP11A1, and HSD3B decreased significantly when Kp-10 was added (p < 0.05).
  4. 04LabIn vitro (cells)Mechanism

    In caprine luteal cells in vitro, Kp-10 significantly decreased CYP11A1 protein and mRNA levels.

    In plain wordsIn goat luteal cells in lab tests, kisspeptin‑10 lowered levels of CYP11A1, a hormone-making enzyme.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseCYP11A1 protein and mRNA
    Study

    goatn: not reported in source

    Temperature-sensitive caprine luteal cell line (ts-CLC-D)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we found that the levels of proteins and mRNA for STAR, CYP11A1, and HSD3B decreased significantly when Kp-10 was added (p < 0.05).
  5. 05LabIn vitro (cells)Mechanism

    In caprine luteal cells in vitro, Kp-10 significantly decreased HSD3B protein and mRNA levels.

    In plain wordsIn goat luteal cells in lab tests, kisspeptin‑10 lowered levels of HSD3B, a hormone-making enzyme.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseHSD3B protein and mRNA
    Study

    goatn: not reported in source

    Temperature-sensitive caprine luteal cell line (ts-CLC-D)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, we found that the levels of proteins and mRNA for STAR, CYP11A1, and HSD3B decreased significantly when Kp-10 was added (p < 0.05).
  6. 06LabIn vitro (cells)Mechanism

    In caprine luteal cells in vitro, Kp-10 did not change mRNA levels of PLCG2, DAG1, PRKCA, KRAS, RAF1, MAP2K1, MAP2K2, MAPK3, MAPK1 or MAPK14.

    In plain wordsIn goat luteal cells in lab tests, kisspeptin‑10 did not change the activity of the genes tested in the MAPK pathway.

    Peptide
    Kisspeptin-10
    Outcome
    No significant changeMAPK pathway-related mRNA levels
    Study

    goatn: not reported in source

    Temperature-sensitive caprine luteal cell line (ts-CLC-D)
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, adding Kp-10 did not affect the mRNA levels for PLCG2, DAG1, PRKCA, KRAS, RAF1, MAP2K1, MAP2K2, MAPK3, MAPK1, and MAPK14.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 07AnimalEndogenous levelAnimal study (in vivo)Other

    In corpus luteal cells of goats, proteins and mRNAs for KISS1 and KISS1R were present.

    In plain wordsIn goats, corpus luteal cells contained the body's own kisspeptin and its receptor.

    Peptide
    Kisspeptin-10
    Outcome
    Not applicableKISS1 and KISS1R in corpus luteal cells in vivo
    Study

    goatn: not reported in source

    Corpus luteal cells of female crossbred Taiwan native goats in the estrous cycle
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    We observed the presence of proteins and mRNAs for STAR, CYP11A1, HSD3B, KISS1, and KISS1R in the corpus luteal cells from goats in vivo.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.