Nicotinamide Mononucleotide Prevents Cisplatin-Induced Cognitive Impairments.

Yoo KH, Tang JJ, Rashid MA, Cho CH, Corujo-Ramirez A, Choi J, Bae MG, Brogren D, Hawse JR, Hou X, Weroha SJ, Oliveros A, Kirkeby LA, Baur JA, Jang MH

Cancer research26 Mar 2021Cited by 41 (Europe PMC)

PMID33771896PMCIDPMC8277702DOI10.1158/0008-5472.can-20-3290PepBankPUB-33771896

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Summary

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Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In cisplatin-exposed mice, NMN prevented abnormalities in neural progenitor proliferation.
In plain wordsIn mice, NMN prevented abnormal neural progenitor proliferation compared with cisplatin alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableNeural progenitor proliferation
Study
mousen: not reported in source
Adult female mice exposed to cisplatin
Comparator
Cisplatin without NMN
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Increasing NAD⁺ levels through nicotinamide mononucleotide (NMN) administration prevented cisplatin-induced abnormalities in neural progenitor proliferation, neuronal morphogenesis, and cognitive function without affecting tumor growth and antitumor efficacy of cisplatin.
1 context sentence(design, population, supporting numbers)
Summary · context
Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD⁺) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro.
Report a problemFND-3377189601
02AnimalAnimal study (in vivo)Efficacy outcome
In cisplatin-exposed mice, NMN prevented abnormalities in neuronal morphogenesis.
In plain wordsIn mice, NMN prevented abnormal neuron development compared with cisplatin alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableNeuronal morphogenesis
Study
mousen: not reported in source
Adult female mice exposed to cisplatin
Comparator
Cisplatin without NMN
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Increasing NAD⁺ levels through nicotinamide mononucleotide (NMN) administration prevented cisplatin-induced abnormalities in neural progenitor proliferation, neuronal morphogenesis, and cognitive function without affecting tumor growth and antitumor efficacy of cisplatin.
1 context sentence(design, population, supporting numbers)
Summary · context
Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD⁺) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro.
Report a problemFND-3377189602
03AnimalAnimal study (in vivo)Efficacy outcome
In cisplatin-exposed mice, NMN prevented cognitive abnormalities.
In plain wordsIn mice, NMN prevented cognitive abnormalities compared with cisplatin alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
Not applicableCognitive function
Study
mousen: not reported in source
Adult female mice exposed to cisplatin
Comparator
Cisplatin without NMN
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Increasing NAD⁺ levels through nicotinamide mononucleotide (NMN) administration prevented cisplatin-induced abnormalities in neural progenitor proliferation, neuronal morphogenesis, and cognitive function without affecting tumor growth and antitumor efficacy of cisplatin.
1 context sentence(design, population, supporting numbers)
Summary · context
Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD⁺) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro.
Report a problemFND-3377189603
04AnimalAnimal study (in vivo)Efficacy outcome
In cisplatin-treated mice, NMN did not affect tumor growth.
In plain wordsIn mice, NMN did not change tumor growth compared with cisplatin alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
No significant changeTumor growth
Study
mousen: not reported in source
Adult female mice exposed to cisplatin
Comparator
Cisplatin without NMN
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Increasing NAD⁺ levels through nicotinamide mononucleotide (NMN) administration prevented cisplatin-induced abnormalities in neural progenitor proliferation, neuronal morphogenesis, and cognitive function without affecting tumor growth and antitumor efficacy of cisplatin.
1 context sentence(design, population, supporting numbers)
Summary · context
Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD⁺) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro.
Report a problemFND-3377189604
05AnimalAnimal study (in vivo)Efficacy outcome
In cisplatin-treated mice, NMN did not affect cisplatin's antitumor efficacy.
In plain wordsIn mice, NMN did not change cisplatin's effect against tumors compared with cisplatin alone.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
No significant changeCisplatin antitumor efficacy
Study
mousen: not reported in source
Adult female mice exposed to cisplatin
Comparator
Cisplatin without NMN
Outcome group
Tumor growth · Cancer
Studied dose
Dose not stated
Source sentences
Summary
Increasing NAD⁺ levels through nicotinamide mononucleotide (NMN) administration prevented cisplatin-induced abnormalities in neural progenitor proliferation, neuronal morphogenesis, and cognitive function without affecting tumor growth and antitumor efficacy of cisplatin.
1 context sentence(design, population, supporting numbers)
Summary · context
Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD⁺) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro.
Report a problemFND-3377189605
06AnimalAnimal study (in vivo)Mechanism
In the cisplatin neurotoxicity model, NMN administration increased NAD+ levels.
In plain wordsIn mice exposed to cisplatin, NMN increased NAD+ levels.
Peptide
NMN (nicotinamide mononucleotide)
Outcome
IncreaseNAD+ levels
Study
mousen: not reported in source
Cisplatin neurotoxicity
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated
Source sentences
Summary
Increasing NAD⁺ levels through nicotinamide mononucleotide (NMN) administration prevented cisplatin-induced abnormalities in neural progenitor proliferation, neuronal morphogenesis, and cognitive function without affecting tumor growth and antitumor efficacy of cisplatin.
1 context sentence(design, population, supporting numbers)
Summary · context
Using the platinum-based chemotherapy cisplatin as a model for CICI, we show here that cisplatin suppresses nicotinamide adenine dinucleotide (NAD⁺) levels in the adult female mouse brain in vivo and in human cortical neurons derived from induced pluripotent stem cells in vitro.
Report a problemFND-3377189606

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Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
21 Oct 2026, 15:58 UTC
Study results updated
Version 1
21 Oct 2026, 12:50 UTC
First added · source update from Europe PMC

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