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Study · Systematic review · n = 28 · 2021

5 results

Pharmacological and non-pharmacological strategies for obese women with subfertility.

Taghavi SA, van Wely M, Jahanfar S, Bazarganipour F

The Cochrane database of systematic reviews25 Mar 2021Cited by 7 (Europe PMC)

PMID33765343 (opens in a new tab)PMCIDPMC8094444 (opens in a new tab)DOI10.1002/14651858.cd012650.pub2 (opens in a new tab)PepBankPUB-33765343
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. 5 results from people.

  1. 01HumanSystematic reviewSafety outcome

    In obese women with subfertility, the effect of metformin plus liraglutide versus metformin alone on nausea was uncertain (OR 7.22, 95% CI 0.72 to 72.7; 1 study).

    In plain wordsIn obese women with subfertility, it is unclear whether adding liraglutide to metformin changes nausea compared with metformin alone.

    Peptide
    Liraglutide
    Outcome
    No significant changeNausea
    Study

    n = 28

    Comparator
    Metformin
    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Measurements

    OR
    7.22
    nausea

    Source sentences

    Summary
    For metformin plus liraglutide compared to metformin we are uncertain of an effect on the adverse events nausea (OR 7.22, 95% CI 0.72 to 72.7; 28 women, 1 study; very low-quality evidence)
    1 context sentence
    Summary · context
    To assess the effectiveness and safety of pharmacological and non-pharmacological strategies compared with each other, placebo, or no treatment for achieving weight loss in obese women with subfertility.
  2. 02HumanSystematic reviewSafety outcome

    In obese women with subfertility, the effect of metformin plus liraglutide versus metformin alone on diarrhoea was uncertain (OR 0.31, 95% CI 0.01 to 8.3; 1 study).

    In plain wordsIn obese women with subfertility, it is unclear whether adding liraglutide to metformin changes diarrhoea compared with metformin alone.

    Peptide
    Liraglutide
    Outcome
    No significant changeDiarrhoea
    Study

    n = 28

    Comparator
    Metformin
    Outcome group
    Gastrointestinal adverse events · Gastrointestinal
    Studied dose
    Dose not stated

    Measurements

    OR
    0.31
    diarrhoea

    Source sentences

    Summary
    diarrhoea (OR 0.31, 95% CI 0.01 to 8.3; 28 women, 1 study; very low-quality evidence)
    2 context sentences
    Summary · context
    For metformin plus liraglutide compared to metformin we are uncertain of an effect on the adverse events
    Summary · context
    To assess the effectiveness and safety of pharmacological and non-pharmacological strategies compared with each other, placebo, or no treatment for achieving weight loss in obese women with subfertility.
  3. 03HumanSystematic reviewSafety outcome

    In obese women with subfertility, the effect of metformin plus liraglutide versus metformin alone on headache was uncertain (OR 5.80, 95% CI 0.25 to 133; 1 study).

    In plain wordsIn obese women with subfertility, it is unclear whether adding liraglutide to metformin changes headache compared with metformin alone.

    Peptide
    Liraglutide
    Outcome
    No significant changeHeadache
    Study

    n = 28

    Comparator
    Metformin
    Outcome group
    Adverse events · Nervous system and cognition
    Studied dose
    Dose not stated

    Measurements

    OR
    5.8
    headache

    Source sentences

    Summary
    headache (OR 5.80, 95% CI 0.25 to 133; 28 women, 1 study; very low-quality evidence)
    2 context sentences
    Summary · context
    For metformin plus liraglutide compared to metformin we are uncertain of an effect on the adverse events
    Summary · context
    To assess the effectiveness and safety of pharmacological and non-pharmacological strategies compared with each other, placebo, or no treatment for achieving weight loss in obese women with subfertility.
  4. 04HumanSystematic reviewEfficacy outcome

    In obese women with subfertility, the effect of metformin plus liraglutide versus metformin alone on BMI was uncertain (MD 2.1, 95% CI -0.42 to 2.62; 1 study).

    In plain wordsIn obese women with subfertility, it is unclear whether adding liraglutide to metformin changes BMI compared with metformin alone.

    Peptide
    Liraglutide
    Outcome
    No significant changeBMI
    Study

    n = 28

    Comparator
    Metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    2.1
    BMI

    Source sentences

    Summary
    We are uncertain if a combination of metformin plus liraglutide vs metformin affects BMI (MD 2.1, 95% CI -0.42 to 2.62; 28 women, 1 study; very low-quality evidence)
    1 context sentence
    Summary · context
    To assess the effectiveness and safety of pharmacological and non-pharmacological strategies compared with each other, placebo, or no treatment for achieving weight loss in obese women with subfertility.
  5. 05HumanSystematic reviewEfficacy outcome

    In obese women with subfertility, the effect of metformin plus liraglutide versus metformin alone on total body fat was uncertain (MD -0.50, 95% CI -4.65 to 3.65; 1 study).

    In plain wordsIn obese women with subfertility, it is unclear whether adding liraglutide to metformin changes total body fat compared with metformin alone.

    Peptide
    Liraglutide
    Outcome
    No significant changeTotal body fat
    Study

    n = 28

    Comparator
    Metformin
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Measurements

    MD
    −0.5
    total body fat

    Source sentences

    Summary
    total body fat (MD -0.50, 95% CI -4.65 to 3.65; 28 women, 1 study; very low-quality evidence)
    2 context sentences
    Summary · context
    We are uncertain if a combination of metformin plus liraglutide vs metformin
    Summary · context
    To assess the effectiveness and safety of pharmacological and non-pharmacological strategies compared with each other, placebo, or no treatment for achieving weight loss in obese women with subfertility.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    12 Oct 2026, 11:11 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:05 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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