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Study · In vitro (cells) · 2021

7 results

Mitochondrial humanin peptide acts as a cytoprotective factor in granulosa cell survival.

Marvaldi C, Martin D, Conte JG, Gottardo MF, Pidre ML, Imsen M, Irizarri M, Manuel SL, Duncan FE, Romanowski V, Seilicovich A, Jaita G

Reproduction (Cambridge, England)20 Apr 2021Cited by 10 (Europe PMC)

PMID33764899 (opens in a new tab)DOI10.1530/rep-20-0197 (opens in a new tab)PepBankPUB-33764899
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In KGN cells, treatment with exogenous humanin increased cell viability.

    In plain wordsIn cells, added humanin kept more KGN cells alive.

    Peptide
    Humanin
    Outcome
    IncreaseKGN cell viability with exogenous humanin
    Study

    n: not reported in source

    KGN granulosa tumor cell line
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment of KGN cells with exogenous HN increased cell viability
  2. 02LabIn vitro (cells)Activity measurement

    In KGN cells, treatment with exogenous humanin decreased apoptosis.

    In plain wordsIn cells, added humanin reduced cell death in KGN cells.

    Peptide
    Humanin
    Outcome
    DecreaseKGN cell apoptosis with exogenous humanin
    Study

    n: not reported in source

    KGN granulosa tumor cell line
    Outcome group
    Cell viability and death · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    treatment of KGN cells with exogenous HN increased cell viability and decreased apoptosis.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 03LabEndogenous levelIn vitro (cells)Other

    Humanin was detected in the KGN granulosa tumor cell line.

    In plain wordsIn cells, the body's own humanin was found in a granulosa tumor cell line.

    Peptide
    Humanin
    Outcome
    Not applicableHumanin detection in KGN cells
    Study

    n: not reported in source

    KGN granulosa tumor cell line
    Outcome group
    Cell viability and death · Reproductive and sexual health

    Source sentences

    Summary
    HN was also detected in a granulosa tumor cell line (KGN).

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone4

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 04AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Silencing humanin with a baculovirus-delivered shRNA modified ovarian histoarchitecture.

    In plain wordsIn the ovary, switching off the humanin gene changed the structure of the tissue.

    Peptide
    Humanin
    Outcome
    MixedOvarian histoarchitecture after humanin knockdown
    Study

    n: not reported in source

    Ovary with baculovirus shRNA silencing of humanin
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    HN downregulation modified ovarian histoarchitecture
    1 context sentence
    Summary · context
    To explore endogenous HN function in the ovary, we used a recombinant baculovirus (BV) encoding a short-hairpin RNA targeted to silence HN (shHN).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 05AnimalNot a test of Humanin aloneAnimal study (in vivo)Mechanism

    Silencing humanin with a baculovirus-delivered shRNA increased apoptosis of granulosa cells in the ovary.

    In plain wordsIn the ovary, switching off the humanin gene led to more death of granulosa cells.

    Peptide
    Humanin
    Outcome
    IncreaseGranulosa cell apoptosis after humanin knockdown
    Study

    n: not reported in source

    Ovary with baculovirus shRNA silencing of humanin
    Outcome group
    Cell viability and death · Reproductive and sexual health

    Source sentences

    Summary
    HN downregulation modified ovarian histoarchitecture and increased apoptosis of granulosa cells.
    1 context sentence
    Summary · context
    To explore endogenous HN function in the ovary, we used a recombinant baculovirus (BV) encoding a short-hairpin RNA targeted to silence HN (shHN).

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  3. 06LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    Transduction of KGN cells with BV-shHN resulted in humanin downregulation.

    In plain wordsIn cells, the baculovirus that silences humanin lowered humanin levels in KGN cells.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin expression in KGN cells after BV-shHN transduction
    Study

    n: not reported in source

    KGN cells transduced with BV-shHN
    Outcome group
    Cell viability and death · Reproductive and sexual health

    Source sentences

    Summary
    Transduction of KGN cells with BV-shHN resulted in HN downregulation

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  4. 07LabNot a test of Humanin aloneIn vitro (cells)Mechanism

    Transduction of KGN cells with BV-shHN increased apoptosis.

    In plain wordsIn cells, switching off the humanin gene led to more cell death in KGN cells.

    Peptide
    Humanin
    Outcome
    IncreaseApoptosis in KGN cells after humanin knockdown
    Study

    n: not reported in source

    KGN cells transduced with BV-shHN
    Outcome group
    Cell viability and death · Reproductive and sexual health

    Source sentences

    Summary
    Transduction of KGN cells with BV-shHN resulted in HN downregulation and increased apoptosis.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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