Pituitary response to GnRH stimulation tests in different FSHB-211 G/T genotypes.

Sansone A, Schubert M, Tüttelmann F, Krallmann C, Zitzmann M, Kliesch S, Gromoll J

Human reproduction (Oxford, England)1 Apr 2021Cited by 4 (Europe PMC)

PMID33704441DOI10.1093/humrep/deab033PepBankPUB-33704441

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. 6 results from people.

01HumanObservational studyActivity measurement
In men with suspected secondary hypogonadism, serum FSH rose markedly after an intravenous 100 µg bolus of gonadorelin.
In plain wordsIn men tested for low testosterone, FSH rose markedly after a gonadorelin injection.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreaseFSH rise after gonadorelin
Study
n = 67
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 µg · intravenousAs given in this study (human).
Source sentences
Summary
An overall marked increase in serum FSH and LH following administration i.v. of 100 µg of an LHRH-analogue was found (P < 0.0001 for linear trend, both models).
2 context sentences(design, population, supporting numbers)
Summary · context
This was a cross-sectional, retrospective study on 67 male subjects (mean age: 24.6 ± 10.3 years) undergoing a GnRH stimulation test for diagnostic purposes in cases of secondary hypogonadism.
Summary · context
A GnRH stimulation test was performed by administering an i.v. bolus of 100 µg of the GnRH-analogue gonadorelin acetate to all patients, with blood samples drawn from the cubital vein immediately prior to injection (T0) and 30 (T1) and 45 minutes (T2) after.
Report a problemFND-3370444101
02HumanObservational studyActivity measurement
In men with suspected secondary hypogonadism, serum LH rose markedly after an intravenous 100 µg bolus of gonadorelin.
In plain wordsIn men tested for low testosterone, LH rose markedly after a gonadorelin injection.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreaseLH rise after gonadorelin
Study
n = 67
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 µg · intravenousAs given in this study (human).
Source sentences
Summary
An overall marked increase in serum FSH and LH following administration i.v. of 100 µg of an LHRH-analogue was found (P < 0.0001 for linear trend, both models).
2 context sentences(design, population, supporting numbers)
Summary · context
This was a cross-sectional, retrospective study on 67 male subjects (mean age: 24.6 ± 10.3 years) undergoing a GnRH stimulation test for diagnostic purposes in cases of secondary hypogonadism.
Summary · context
A GnRH stimulation test was performed by administering an i.v. bolus of 100 µg of the GnRH-analogue gonadorelin acetate to all patients, with blood samples drawn from the cubital vein immediately prior to injection (T0) and 30 (T1) and 45 minutes (T2) after.
Report a problemFND-3370444102
03HumanObservational studyActivity measurement
After gonadorelin, peak LH was significantly higher in men with the TT genotype than in GT and GG carriers.
In plain wordsAfter a gonadorelin injection, peak LH was higher in men with two T alleles than in other men.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
IncreasePeak LH by FSHB-211 genotype
Study
n = 67
Comparator
GT and GG carriers
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 µg · intravenousAs given in this study (human).
Source sentences
Summary
Peak levels of LH were significantly higher in TT carriers than in GT and GG carriers (P = 0.012)
2 context sentences(design, population, supporting numbers)
Summary · context
This was a cross-sectional, retrospective study on 67 male subjects (mean age: 24.6 ± 10.3 years) undergoing a GnRH stimulation test for diagnostic purposes in cases of secondary hypogonadism.
Summary · context
A GnRH stimulation test was performed by administering an i.v. bolus of 100 µg of the GnRH-analogue gonadorelin acetate to all patients, with blood samples drawn from the cubital vein immediately prior to injection (T0) and 30 (T1) and 45 minutes (T2) after.
Report a problemFND-3370444103
04HumanObservational studyActivity measurement
After gonadorelin, stimulated FSH levels did not differ significantly between FSHB-211 genotype groups.
In plain wordsAfter a gonadorelin injection, FSH levels did not differ between genotype groups.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
No significant changePeak FSH by FSHB-211 genotype
Study
n = 67
Comparator
Other FSHB-211 genotype groups
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 µg · intravenousAs given in this study (human).
Source sentences
Summary
no significant between-groups difference was found concerning stimulated FSH levels.
2 context sentences(design, population, supporting numbers)
Summary · context
This was a cross-sectional, retrospective study on 67 male subjects (mean age: 24.6 ± 10.3 years) undergoing a GnRH stimulation test for diagnostic purposes in cases of secondary hypogonadism.
Summary · context
A GnRH stimulation test was performed by administering an i.v. bolus of 100 µg of the GnRH-analogue gonadorelin acetate to all patients, with blood samples drawn from the cubital vein immediately prior to injection (T0) and 30 (T1) and 45 minutes (T2) after.
Report a problemFND-3370444104
05HumanObservational studyActivity measurement
After gonadorelin, the FSH response over time was attenuated in T-allele carriers compared with GG carriers, with no significant main effect of the T allele.
In plain wordsAfter a gonadorelin injection, FSH rose less over time in men carrying a T allele than in GG men.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
DecreaseFSH response over time by FSHB-211 genotype
Study
n = 67
Comparator
GG carriers
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 µg · intravenousAs given in this study (human).
Source sentences
Summary
In both the additive and recessive model, the main effect of T allele(s) did not reach statistical significance concerning FSH levels (P = 0.9502 and P = 0.8576, respectively), yet interaction effects over time demonstrated an attenuated response in T-allele carriers compared to the GG-allele carrie…
2 context sentences(design, population, supporting numbers)
Summary · context
This was a cross-sectional, retrospective study on 67 male subjects (mean age: 24.6 ± 10.3 years) undergoing a GnRH stimulation test for diagnostic purposes in cases of secondary hypogonadism.
Summary · context
A GnRH stimulation test was performed by administering an i.v. bolus of 100 µg of the GnRH-analogue gonadorelin acetate to all patients, with blood samples drawn from the cubital vein immediately prior to injection (T0) and 30 (T1) and 45 minutes (T2) after.
Report a problemFND-3370444105
06HumanObservational studyActivity measurement
After gonadorelin, genotype had significant main and interaction effects on LH in both the additive and recessive models.
In plain wordsAfter a gonadorelin injection, the LH response differed significantly by genotype in both statistical models.
Peptide
Gonadorelin (GnRH, LHRH)
Outcome
Direction not reportedLH response over time by FSHB-211 genotype
Study
n = 67
Outcome group
Sex hormones and fertility · Endocrine and hormones
Studied dose
100 µg · intravenousAs given in this study (human).
Source sentences
Summary
Main and interaction effects for LH were significant in both the additive (P = 0.0022 and P = 0.0013, respectively) and recessive model (P = 0.0025 and P = 0.0016, respectively).
2 context sentences(design, population, supporting numbers)
Summary · context
This was a cross-sectional, retrospective study on 67 male subjects (mean age: 24.6 ± 10.3 years) undergoing a GnRH stimulation test for diagnostic purposes in cases of secondary hypogonadism.
Summary · context
A GnRH stimulation test was performed by administering an i.v. bolus of 100 µg of the GnRH-analogue gonadorelin acetate to all patients, with blood samples drawn from the cubital vein immediately prior to injection (T0) and 30 (T1) and 45 minutes (T2) after.
Report a problemFND-3370444106

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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MeSH terms

Keywords

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