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Study · Animal study (in vivo) · rat · 2021

9 results

Humanin Alleviates Insulin Resistance in Polycystic Ovary Syndrome: A Human and Rat Model-Based Study.

Wang Y, Zeng Z, Zhao S, Tang L, Yan J, Li N, Zou L, Fan X, Xu C, Huang J, Xia W, Zhu C, Rao M

Endocrinology1 Aug 2021Cited by 17 (Europe PMC)

PMID33693742 (opens in a new tab)DOI10.1210/endocr/bqab056 (opens in a new tab)PepBankPUB-33693742
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study9

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DHEA-induced PCOS, HNG supplementation attenuated the increase in fasting plasma glucose.

    In plain wordsIn rats with PCOS, a humanin analogue reduced the rise in fasting blood glucose.

    Peptide
    Humanin
    Outcome
    DecreaseFasting plasma glucose in PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG supplementation attenuated both the increases in the levels of fasting plasma glucose
    1 context sentence
    Summary · context
    We further investigated the effect of humanin analogue (HNG) supplementation on IR in a rat model of dehydroepiandrosterone-induced PCOS.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DHEA-induced PCOS, HNG supplementation attenuated the increase in fasting insulin.

    In plain wordsIn rats with PCOS, a humanin analogue reduced the rise in fasting insulin.

    Peptide
    Humanin
    Outcome
    DecreaseFasting insulin in PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Glycemic control · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG supplementation attenuated both the increases in the levels of fasting plasma glucose and fasting insulin in rats with PCOS and the decreases in phosphorylation of IRS1, PI3K, AKT, and GLUT4 proteins in the granulosa cells of these rats.
    1 context sentence
    Summary · context
    We further investigated the effect of humanin analogue (HNG) supplementation on IR in a rat model of dehydroepiandrosterone-induced PCOS.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In granulosa cells of rats with DHEA-induced PCOS, HNG supplementation attenuated the decrease in IRS1 phosphorylation.

    In plain wordsIn rats with PCOS, a humanin analogue reduced the drop in a cell signal (IRS1) in ovary cells.

    Peptide
    Humanin
    Outcome
    IncreaseIRS1 phosphorylation in granulosa cells of PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG supplementation attenuated both the increases in the levels of fasting plasma glucose and fasting insulin in rats with PCOS and the decreases in phosphorylation of IRS1, PI3K, AKT, and GLUT4 proteins in the granulosa cells of these rats.
    1 context sentence
    Summary · context
    We further investigated the effect of humanin analogue (HNG) supplementation on IR in a rat model of dehydroepiandrosterone-induced PCOS.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In granulosa cells of rats with DHEA-induced PCOS, HNG supplementation attenuated the decrease in PI3K phosphorylation.

    In plain wordsIn rats with PCOS, a humanin analogue reduced the drop in a cell signal (PI3K) in ovary cells.

    Peptide
    Humanin
    Outcome
    IncreasePI3K phosphorylation in granulosa cells of PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG supplementation attenuated both the increases in the levels of fasting plasma glucose and fasting insulin in rats with PCOS and the decreases in phosphorylation of IRS1, PI3K, AKT, and GLUT4 proteins in the granulosa cells of these rats.
    1 context sentence
    Summary · context
    We further investigated the effect of humanin analogue (HNG) supplementation on IR in a rat model of dehydroepiandrosterone-induced PCOS.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In granulosa cells of rats with DHEA-induced PCOS, HNG supplementation attenuated the decrease in AKT phosphorylation.

    In plain wordsIn rats with PCOS, a humanin analogue reduced the drop in a cell signal (AKT) in ovary cells.

    Peptide
    Humanin
    Outcome
    IncreaseAKT phosphorylation in granulosa cells of PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG supplementation attenuated both the increases in the levels of fasting plasma glucose and fasting insulin in rats with PCOS and the decreases in phosphorylation of IRS1, PI3K, AKT, and GLUT4 proteins in the granulosa cells of these rats.
    1 context sentence
    Summary · context
    We further investigated the effect of humanin analogue (HNG) supplementation on IR in a rat model of dehydroepiandrosterone-induced PCOS.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In granulosa cells of rats with DHEA-induced PCOS, HNG supplementation attenuated the decrease in GLUT4 protein.

    In plain wordsIn rats with PCOS, a humanin analogue reduced the drop in a glucose transport protein (GLUT4) in ovary cells.

    Peptide
    Humanin
    Outcome
    IncreaseGLUT4 in granulosa cells of PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG supplementation attenuated both the increases in the levels of fasting plasma glucose and fasting insulin in rats with PCOS and the decreases in phosphorylation of IRS1, PI3K, AKT, and GLUT4 proteins in the granulosa cells of these rats.
    1 context sentence
    Summary · context
    We further investigated the effect of humanin analogue (HNG) supplementation on IR in a rat model of dehydroepiandrosterone-induced PCOS.

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 07HumanEndogenous levelObservational studyOther

    In women with PCOS, follicular fluid humanin was significantly lower in those with insulin resistance than in those without.

    In plain wordsIn women with PCOS, the body's own humanin in ovary fluid was lower in those with insulin resistance than in those without.

    Peptide
    Humanin
    Outcome
    DecreaseFollicular fluid humanin in PCOS with versus without insulin resistance
    Study

    n: not reported in source

    Comparator
    PCOS patients without insulin resistance
    Outcome group
    Endogenous peptide levels · Endocrine and hormones

    Source sentences

    Summary
    Humanin concentrations in the follicular fluid were found to be significantly lower in PCOS patients with IR than in those without IR.
    1 context sentence
    Summary · context
    In this study, we compared humanin concentrations in follicular fluid from PCOS patients with and without IR.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone2

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

  1. 08LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In normal COV434 cells, combined supplementation with HNG and insulin significantly improved glucose consumption.

    In plain wordsIn cells, humanin analogue plus insulin together raised glucose use. The result does not show the effect of the analogue alone.

    Peptide
    Humanin
    Outcome
    IncreaseGlucose consumption with HNG plus insulin in normal COV434 cells
    Study

    n: not reported in source

    Normal COV434 cells
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Combined supplementation with HNG and insulin significantly improved glucose consumption in normal

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

  2. 09LabNot a test of Humanin aloneIn vitro (cells)Efficacy outcome

    In humanin-siRNA-transfected COV434 cells, combined supplementation with HNG and insulin significantly improved glucose consumption.

    In plain wordsIn cells with less humanin, humanin analogue plus insulin together raised glucose use. The result does not show the effect of the analogue alone.

    Peptide
    Humanin
    Outcome
    IncreaseGlucose consumption with HNG plus insulin in humanin-siRNA-transfected COV434 cells
    Study

    n: not reported in source

    Humanin-siRNA-transfected COV434 cells
    Outcome group
    Glycemic control · Metabolic and weight

    Source sentences

    Summary
    Combined supplementation with HNG and insulin significantly improved glucose consumption in normal and humanin-siRNA-transfected COV434 cells.

    In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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