Comparison between liraglutide alone and liraglutide in combination with insulin on osteoporotic rats and their effect on bone mineral density.

Chen K, Wu R, Mo B, Yan X, Shen D, Chen M

Journal of musculoskeletal & neuronal interactions1 Mar 2021Cited by 9 (Europe PMC)

PMID33657765PMCIDPMC8020012PepBankPUB-33657765

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study6

2 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with diabetes and osteoporosis, bone mineral density was higher with liraglutide than in the control group.
In plain wordsIn rats with diabetes and weak bones, liraglutide treatment gave higher bone density than no treatment.
Peptide
Liraglutide
Outcome
IncreaseBone mineral density, liraglutide versus control
Study
ratn: not reported in source
Rats with diabetes combined with osteoporosis
Comparator
Control group
Outcome group
Bone and joint · Musculoskeletal
Studied dose
Dose not stated
Source sentences
Summary
BMD of the control group was significantly lower than that of the other three groups (p<0.05) and BMD of the LRG + Ins group was significantly higher than that of the LRG group (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
40 Sprague-Dawley rats were divided into four groups (blank, control, LRG and LRG+Ins).
Report a problemFND-3365776501
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with diabetes and osteoporosis, inflammatory factors were lower with liraglutide than in the control group.
In plain wordsIn rats with diabetes and weak bones, liraglutide treatment gave lower levels of inflammation markers than no treatment.
Peptide
Liraglutide
Outcome
DecreaseInflammatory factors, liraglutide versus control
Study
ratn: not reported in source
Rats with diabetes combined with osteoporosis
Comparator
Control group
Outcome group
Inflammation markers · Immune and inflammation
Studied dose
Dose not stated
Source sentences
Summary
The inflammatory factors of the control group were significantly higher than those in the other three groups (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
40 Sprague-Dawley rats were divided into four groups (blank, control, LRG and LRG+Ins).
Report a problemFND-3365776504

Studies that did not test the peptide alone4

In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Liraglutide.

03AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Efficacy outcome
In rats with diabetes and osteoporosis, bone mineral density was higher with liraglutide plus insulin than in the control group.
In plain wordsIn rats with diabetes and weak bones, liraglutide plus insulin gave higher bone density than no treatment.
Peptide
Liraglutide
Outcome
IncreaseBone mineral density, liraglutide plus insulin versus control
Study
ratn: not reported in source
Rats with diabetes combined with osteoporosis
Comparator
Control group
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
BMD of the control group was significantly lower than that of the other three groups (p<0.05) and BMD of the LRG + Ins group was significantly higher than that of the LRG group (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
40 Sprague-Dawley rats were divided into four groups (blank, control, LRG and LRG+Ins).
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3365776502
04AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Efficacy outcome
In rats with diabetes and osteoporosis, bone mineral density was higher with liraglutide plus insulin than with liraglutide alone; the contrast tests the added insulin.
In plain wordsIn rats with diabetes and weak bones, adding insulin to liraglutide gave higher bone density than liraglutide alone.
Peptide
Liraglutide
Outcome
IncreaseBone mineral density, liraglutide plus insulin versus liraglutide alone
Study
ratn: not reported in source
Rats with diabetes combined with osteoporosis
Comparator
Liraglutide alone
Outcome group
Bone and joint · Musculoskeletal
Source sentences
Summary
BMD of the control group was significantly lower than that of the other three groups (p<0.05) and BMD of the LRG + Ins group was significantly higher than that of the LRG group (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
40 Sprague-Dawley rats were divided into four groups (blank, control, LRG and LRG+Ins).
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3365776503
05AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Efficacy outcome
In rats with diabetes and osteoporosis, inflammatory factors were lower with liraglutide plus insulin than in the control group.
In plain wordsIn rats with diabetes and weak bones, liraglutide plus insulin gave lower levels of inflammation markers than no treatment.
Peptide
Liraglutide
Outcome
DecreaseInflammatory factors, liraglutide plus insulin versus control
Study
ratn: not reported in source
Rats with diabetes combined with osteoporosis
Comparator
Control group
Outcome group
Inflammation markers · Immune and inflammation
Source sentences
Summary
The inflammatory factors of the control group were significantly higher than those in the other three groups (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
40 Sprague-Dawley rats were divided into four groups (blank, control, LRG and LRG+Ins).
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3365776505
06AnimalNot a test of Liraglutide aloneAnimal study (in vivo)Mechanism
In rats with diabetes and osteoporosis, inflammatory factors were negatively correlated with bone mineral density.
In plain wordsIn rats with diabetes and weak bones, higher inflammation markers went with lower bone density.
Peptide
Liraglutide
Outcome
Not applicableCorrelation of inflammatory factors with bone mineral density
Study
ratn: not reported in source
Rats with diabetes combined with osteoporosis
Outcome group
Inflammation markers · Musculoskeletal
Source sentences
Summary
The inflammatory factors were negatively correlated with BMD (p<0.05).
1 context sentence(design, population, supporting numbers)
Summary · context
40 Sprague-Dawley rats were divided into four groups (blank, control, LRG and LRG+Ins).
In this study, Liraglutide was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Liraglutide.
Report a problemFND-3365776506

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
12 Oct 2026, 11:11 UTC
Study results updated
Version 1
9 Oct 2026, 03:05 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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