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Study · Non-randomized trial · 2022

4 results

Discrepancy Between Multibiomarker Disease Activity and Clinical Disease Activity Scores in Patients With Persistently Active Rheumatoid Arthritis.

Fleischmann R, Liu J, Zhu J, Segurado OG, Furst DE

Arthritis care & research24 May 2022Cited by 1 (Europe PMC)

PMID33644992 (opens in a new tab)DOI10.1002/acr.24583 (opens in a new tab)PepBankPUB-33644992
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In persistently active RA, changes in DAS28-ESR suggested clinically meaningful improvement after repository corticotropin injection.

    In plain wordsIn active rheumatoid arthritis, joint disease scores suggested meaningful improvement from baseline after repository corticotropin injection.

    Peptide
    ACTH (corticotropin)
    Outcome
    DecreaseDAS28-ESR disease activity
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    80 units twice weeklyAs given in this study (human).

    Source sentences

    Summary
    Changes from baseline in DAS28-ESR and CDAI scores suggested that RCI therapy led to clinically meaningful improvements in disease activity, but improvements from baseline in MBDA scores were below the minimally important difference threshold.
    1 context sentence
    Summary · context
    Patients received 80 units of RCI twice weekly during a 12-week open-label period; those who experienced low disease activity at week 12 were randomly assigned to receive either 80 units of RCI or placebo twice weekly during a 12-week double-blind period.
  2. 02HumanNon-randomized trialEfficacy outcome

    In persistently active RA, changes in CDAI suggested clinically meaningful improvement after repository corticotropin injection.

    In plain wordsIn active rheumatoid arthritis, CDAI scores suggested meaningful improvement from baseline after repository corticotropin injection.

    Peptide
    ACTH (corticotropin)
    Outcome
    DecreaseCDAI disease activity
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    80 units twice weeklyAs given in this study (human).

    Source sentences

    Summary
    Changes from baseline in DAS28-ESR and CDAI scores suggested that RCI therapy led to clinically meaningful improvements in disease activity, but improvements from baseline in MBDA scores were below the minimally important difference threshold.
    1 context sentence
    Summary · context
    Patients received 80 units of RCI twice weekly during a 12-week open-label period; those who experienced low disease activity at week 12 were randomly assigned to receive either 80 units of RCI or placebo twice weekly during a 12-week double-blind period.
  3. 03HumanNon-randomized trialEfficacy outcome

    In persistently active RA, MBDA improvements after repository corticotropin injection were below the minimally important difference threshold.

    In plain wordsIn active rheumatoid arthritis, biomarker score improvements from baseline after repository corticotropin injection fell below the meaningful difference threshold.

    Peptide
    ACTH (corticotropin)
    Outcome
    DecreaseMBDA disease activity
    Study

    n: not reported in source

    Comparator
    Baseline
    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    80 units twice weeklyAs given in this study (human).

    Source sentences

    Summary
    Changes from baseline in DAS28-ESR and CDAI scores suggested that RCI therapy led to clinically meaningful improvements in disease activity, but improvements from baseline in MBDA scores were below the minimally important difference threshold.
    1 context sentence
    Summary · context
    Patients received 80 units of RCI twice weekly during a 12-week open-label period; those who experienced low disease activity at week 12 were randomly assigned to receive either 80 units of RCI or placebo twice weekly during a 12-week double-blind period.
  4. 04HumanObservational studyOther

    In RCI-treated RA patients, CDAI correlations with total and component MBDA scores were generally low and occasionally moderate.

    In plain wordsIn RCI-treated rheumatoid arthritis patients, CDAI and biomarker scores generally correlated weakly and sometimes moderately.

    Peptide
    ACTH (corticotropin)
    Outcome
    Not applicableCDAI correlation with MBDA
    Study

    n: not reported in source

    Outcome group
    Bone and joint · Musculoskeletal
    Studied dose
    80 units twice weeklyAs given in this study (human).

    Measurements

    Correlation r
    ≤ 0.3
    generally, CDAI versus total MBDA and individual components
    Correlation r
    0.3 to 0.5
    occasionally; exclusive bounds, CDAI versus total MBDA and individual components

    Source sentences

    Summary
    For the DAS28-ESR and CDAI, correlations with total MBDA and individual component scores were generally low (r ≤ 0.3) and occasionally moderate (r > 0.3 but r < 0.5).
    1 context sentence
    Summary · context
    Patients received 80 units of RCI twice weekly during a 12-week open-label period; those who experienced low disease activity at week 12 were randomly assigned to receive either 80 units of RCI or placebo twice weekly during a 12-week double-blind period.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    28 Oct 2026, 02:03 UTC

    Study results updated

  2. Version 1

    27 Oct 2026, 16:35 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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