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Study · In vitro (cells) · pig · 2021

4 results

Nicotinamide Mononucleotide Restores the Meiotic Competency of Porcine Oocytes Exposed to Ethylene Glycol Butyl Ether.

Miao Y, Li X, Shi X, Gao Q, Chen J, Wang R, Fan Y, Xiong B

Frontiers in cell and developmental biology2 Feb 2021Cited by 20 (Europe PMC)

PMID33604339 (opens in a new tab)PMCIDPMC7884640 (opens in a new tab)DOI10.3389/fcell.2021.628580 (opens in a new tab)PepBankPUB-33604339
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Summary

Ethylene glycol butyl ether (EGBE), a type of glycol ethers, is a common chemical used in both industrial and household products. Increasing animal studies have indicated that it produces reproductive problems, such as testicular damage, reduced female fertility, death of embryos, and birth defects. However, how it influences the female germ cells has not yet determined. Here, we found that EGBE exposure resulted in the defective porcine oocyte maturation via disruption of cytoskeleton dynamics, showing the abnormal spindle assembly, chromosome alignment, and actin organization. Meanwhile, EGBE exposure perturbed the mitochondrial distribution and function, leading to the accumulation of reactive oxygen species (ROS) and generation of DNA damage and apoptosis. Of note, nicotinamide mononucleotide (NMN) supplementation rescued the meiotic defects caused by EGBE exposure via restoring NAD+ level and mitochondrial function and thus eliminating the excessive ROS. Taken together, our observations illustrate that NMN supplementation is an effective strategy to protect oocyte quality against environmental pollutant-induced deterioration, contributing to improve the animal and human fertility.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In porcine oocytes exposed to EGBE, NMN rescued meiotic defects.

    In plain wordsIn lab tests, NMN reduced meiotic defects in pig egg cells exposed to EGBE compared with EGBE alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseMeiotic defects
    Study

    pign: not reported in source

    Porcine oocytes exposed to EGBE
    Comparator
    EGBE exposure without NMN
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of note, nicotinamide mononucleotide (NMN) supplementation rescued the meiotic defects caused by EGBE exposure via restoring NAD+ level and mitochondrial function and thus eliminating the excessive ROS.
    1 context sentence
    Summary · context
    Here, we found that EGBE exposure resulted in the defective porcine oocyte maturation via disruption of cytoskeleton dynamics, showing the abnormal spindle assembly, chromosome alignment, and actin organization.
  2. 02LabIn vitro (cells)Efficacy outcome

    In porcine oocytes exposed to EGBE, NMN restored NAD+ levels.

    In plain wordsIn lab tests, NMN restored NAD+ levels in pig egg cells exposed to EGBE compared with EGBE alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseNAD+ level
    Study

    pign: not reported in source

    Porcine oocytes exposed to EGBE
    Comparator
    EGBE exposure without NMN
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of note, nicotinamide mononucleotide (NMN) supplementation rescued the meiotic defects caused by EGBE exposure via restoring NAD+ level and mitochondrial function and thus eliminating the excessive ROS.
    1 context sentence
    Summary · context
    Here, we found that EGBE exposure resulted in the defective porcine oocyte maturation via disruption of cytoskeleton dynamics, showing the abnormal spindle assembly, chromosome alignment, and actin organization.
  3. 03LabIn vitro (cells)Efficacy outcome

    In porcine oocytes exposed to EGBE, NMN restored mitochondrial function.

    In plain wordsIn lab tests, NMN restored mitochondrial function in pig egg cells exposed to EGBE compared with EGBE alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial function
    Study

    pign: not reported in source

    Porcine oocytes exposed to EGBE
    Comparator
    EGBE exposure without NMN
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of note, nicotinamide mononucleotide (NMN) supplementation rescued the meiotic defects caused by EGBE exposure via restoring NAD+ level and mitochondrial function and thus eliminating the excessive ROS.
    1 context sentence
    Summary · context
    Here, we found that EGBE exposure resulted in the defective porcine oocyte maturation via disruption of cytoskeleton dynamics, showing the abnormal spindle assembly, chromosome alignment, and actin organization.
  4. 04LabIn vitro (cells)Efficacy outcome

    In porcine oocytes exposed to EGBE, NMN eliminated excess reactive oxygen species.

    In plain wordsIn lab tests, NMN reduced excess reactive oxygen species in pig egg cells exposed to EGBE compared with EGBE alone.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseReactive oxygen species
    Study

    pign: not reported in source

    Porcine oocytes exposed to EGBE
    Comparator
    EGBE exposure without NMN
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Of note, nicotinamide mononucleotide (NMN) supplementation rescued the meiotic defects caused by EGBE exposure via restoring NAD+ level and mitochondrial function and thus eliminating the excessive ROS.
    1 context sentence
    Summary · context
    Here, we found that EGBE exposure resulted in the defective porcine oocyte maturation via disruption of cytoskeleton dynamics, showing the abnormal spindle assembly, chromosome alignment, and actin organization.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

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