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Study · Animal study (in vivo) · mouse · 2021

6 results

Thymosin beta-4 prenatal administration improves fetal development and halts side effects due to preterm delivery.

Faa G, Piras M, Mancuso L, Coni P, Pichiri G, Orrù G, Fanni D, Gerosa C, Cao G, Taibi R, Pavone P, Castagnola M

European review for medical and pharmacological sciences1 Jan 2021Cited by 6 (Europe PMC)

PMID33506933 (opens in a new tab)DOI10.26355/eurrev_202101_24411 (opens in a new tab)PepBankPUB-33506933
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study6

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, maternal TB4 treatment on gestation days E14 and E17 produced newborns with higher cranio-caudal length than control newborns.

    In plain wordsIn mice, pups of mothers given thymosin beta‑4 were longer than control pups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNewborn cranio-caudal length
    Study

    mousen: not reported in source

    pregnant mice
    Comparator
    Control newborns
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    6 mg/kg · intraperitoneal · injections on gestation days E14 and E17As given in this study (mouse).

    Source sentences

    Summary
    The mothers treated with TB4 for two days precisely E14 and E17, showed a higher cranio-caudal length when compared to control newborns.
    1 context sentence
    Summary · context
    At 10:00 a.m. on day E14 and E17 of gestation mice were weighed and treated with an intraperitoneal injection of TB4 (Regene RX, Rockville, MD, USA; 6 mg/kg in PBS).
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, maternal TB4 treatment was associated with more advanced development of the newborn lungs.

    In plain wordsIn mice, maternal thymosin beta‑4 was linked to more advanced lung development in the pups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseLung development at histology
    Study

    mousen: not reported in source

    pregnant mice
    Comparator
    Control newborns
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    6 mg/kg · intraperitoneal · injections on gestation days E14 and E17As given in this study (mouse).

    Source sentences

    Summary
    At histology, maternal TB4 treatment was associated with more advanced development of lungs, heart, kidney, cerebral cortex and notochord.
    1 context sentence
    Summary · context
    At 10:00 a.m. on day E14 and E17 of gestation mice were weighed and treated with an intraperitoneal injection of TB4 (Regene RX, Rockville, MD, USA; 6 mg/kg in PBS).
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice, maternal TB4 treatment was associated with more advanced development of the newborn heart.

    In plain wordsIn mice, maternal thymosin beta‑4 was linked to more advanced heart development in the pups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseHeart development at histology
    Study

    mousen: not reported in source

    pregnant mice
    Comparator
    Control newborns
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    6 mg/kg · intraperitoneal · injections on gestation days E14 and E17As given in this study (mouse).

    Source sentences

    Summary
    At histology, maternal TB4 treatment was associated with more advanced development of lungs, heart, kidney, cerebral cortex and notochord.
    1 context sentence
    Summary · context
    At 10:00 a.m. on day E14 and E17 of gestation mice were weighed and treated with an intraperitoneal injection of TB4 (Regene RX, Rockville, MD, USA; 6 mg/kg in PBS).
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice, maternal TB4 treatment was associated with more advanced development of the newborn kidney.

    In plain wordsIn mice, maternal thymosin beta‑4 was linked to more advanced kidney development in the pups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseKidney development at histology
    Study

    mousen: not reported in source

    pregnant mice
    Comparator
    Control newborns
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    6 mg/kg · intraperitoneal · injections on gestation days E14 and E17As given in this study (mouse).

    Source sentences

    Summary
    At histology, maternal TB4 treatment was associated with more advanced development of lungs, heart, kidney, cerebral cortex and notochord.
    1 context sentence
    Summary · context
    At 10:00 a.m. on day E14 and E17 of gestation mice were weighed and treated with an intraperitoneal injection of TB4 (Regene RX, Rockville, MD, USA; 6 mg/kg in PBS).
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice, maternal TB4 treatment was associated with more advanced development of the newborn cerebral cortex.

    In plain wordsIn mice, maternal thymosin beta‑4 was linked to more advanced brain cortex development in the pups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseCerebral cortex development at histology
    Study

    mousen: not reported in source

    pregnant mice
    Comparator
    Control newborns
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    6 mg/kg · intraperitoneal · injections on gestation days E14 and E17As given in this study (mouse).

    Source sentences

    Summary
    At histology, maternal TB4 treatment was associated with more advanced development of lungs, heart, kidney, cerebral cortex and notochord.
    1 context sentence
    Summary · context
    At 10:00 a.m. on day E14 and E17 of gestation mice were weighed and treated with an intraperitoneal injection of TB4 (Regene RX, Rockville, MD, USA; 6 mg/kg in PBS).
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice, maternal TB4 treatment was associated with more advanced development of the newborn notochord.

    In plain wordsIn mice, maternal thymosin beta‑4 was linked to more advanced notochord development in the pups.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    IncreaseNotochord development at histology
    Study

    mousen: not reported in source

    pregnant mice
    Comparator
    Control newborns
    Outcome group
    Pregnancy and fetal development · Reproductive and sexual health
    Studied dose
    6 mg/kg · intraperitoneal · injections on gestation days E14 and E17As given in this study (mouse).

    Source sentences

    Summary
    At histology, maternal TB4 treatment was associated with more advanced development of lungs, heart, kidney, cerebral cortex and notochord.
    1 context sentence
    Summary · context
    At 10:00 a.m. on day E14 and E17 of gestation mice were weighed and treated with an intraperitoneal injection of TB4 (Regene RX, Rockville, MD, USA; 6 mg/kg in PBS).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

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