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Study · Animal study (in vivo) · rat · 2021

2 results

Morphofunctional State of the Large Intestine in Rats under Conditions of Restraint Stress and Administration of Peptide ACTH(4-7)-PGP (Semax).

Svishcheva MV, Mishina YS, Medvedeva OA, Bobyntsev II, Mukhina AY, Kalutskii PV, Andreeva LA, Myasoedov NF

Bulletin of experimental biology and medicine18 Jan 2021Cited by 1 (Europe PMC)

PMID33459919 (opens in a new tab)DOI10.1007/s10517-021-05072-z (opens in a new tab)PepBankPUB-33459919
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In male rats under restraint stress, Semax decreased the serum corticosterone concentration.

    In plain wordsIn rats under stress, Semax lowered the level of the stress hormone corticosterone.

    Peptide
    Semax
    Outcome
    DecreaseSerum corticosterone concentration under restraint stress
    Study

    ratn: not reported in source

    restraint stress, colon
    Outcome group
    Stress hormones · Endocrine and hormones
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Administration of the peptide led to a decrease in corticosterone concentration
    1 context sentence
    Summary · context
    We studied the effect of intraperitoneal administration ACTH(4-7)-PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In male rats under restraint stress, Semax alleviated stress-induced pathomorphological changes in the colon wall.

    In plain wordsIn rats under stress, Semax reduced stress-related damage to the structure of the colon wall.

    Peptide
    Semax
    Outcome
    DecreaseStress-induced pathomorphological changes in the colon
    Study

    ratn: not reported in source

    restraint stress, colon
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    5, 50, 150 and 450 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    alleviated stress-induced pathomorphological changes
    1 context sentence
    Summary · context
    We studied the effect of intraperitoneal administration ACTH(4-7)-PGP in doses of 5, 50, 150, and 450 μg/kg to Wistar male rats 12-15 min before modeling restraint stress on the morphofunctional state of the colon.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 19:08 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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