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Study · Animal study (in vivo) · sprague dawley rats · 2020

3 results

Clopidogrel-Induced Gastric Injury in Rats is Attenuated by Stable Gastric Pentadecapeptide BPC 157.

Wu H, Wei M, Li N, Lu Q, Shrestha SM, Tan J, Zhang Z, Wu G, Shi R

Drug design, development and therapy21 Dec 2020Cited by 33 (Europe PMC)

PMID33376304 (opens in a new tab)PMCIDPMC7763470 (opens in a new tab)DOI10.2147/dddt.s284163 (opens in a new tab)PepBankPUB-33376304
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Sprague Dawley rats with healed acetic acid-induced gastric ulcer, BPC‑157 attenuated the gastric mucosal damage caused by clopidogrel.

    In plain wordsIn rats, BPC‑157 reduced the stomach lining damage that the drug clopidogrel caused.

    Peptide
    BPC-157
    Outcome
    DecreaseClopidogrel-induced gastric mucosal damage
    Study

    Sprague Dawley ratsn: not reported in source

    Clopidogrel-induced recurrence of acetic acid-induced gastric ulcer
    Comparator
    Clopidogrel alone
    Outcome group
    Gastrointestinal protection · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 attenuated the gastric mucosal damage caused by Clopidogrel and reversed these molecular effects.
    1 context sentence
    Summary · context
    We used acetic acid to induce gastric ulcer in Sprague Dawley rats. Clopidogrel alone or in combination with BPC 157 or L-NAME (nitric oxide system blockade) were administered after healing of acetic acid-induced ulcer. One percent methylcellulose solution was used as control.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In rats, BPC‑157 reversed the molecular effects of clopidogrel in gastric mucosa: ER stress-related apoptosis, suppressed angiogenic markers and eNOS, and activated AKT and p38/MAPK.

    In plain wordsIn rats, BPC‑157 reversed changes in stomach lining proteins that clopidogrel had caused.

    Peptide
    BPC-157
    Outcome
    MixedClopidogrel-induced molecular changes in gastric mucosa (ER stress apoptosis, VEGF-A/VEGFR1, eNOS, AKT, p38/MAPK)
    Study

    Sprague Dawley ratsn: not reported in source

    Clopidogrel-induced recurrence of acetic acid-induced gastric ulcer
    Comparator
    Clopidogrel alone
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC 157 attenuated the gastric mucosal damage caused by Clopidogrel and reversed these molecular effects.
    3 context sentences
    Summary · context
    This study indicated that Clopidogrel significantly induced the gastric ulcers recurrence, severe inflammation and ER stress related apoptosis of the gastric mucosa, suppressed the synthesis of angiogenic markers and eNOS.
    Summary · context
    Furthermore, Clopidrogel intervention resulted in the activation of protein kinase B (AKT) and p38 mitogen-activated protein kinase (p38/MAPK).
    Summary · context
    We used acetic acid to induce gastric ulcer in Sprague Dawley rats. Clopidogrel alone or in combination with BPC 157 or L-NAME (nitric oxide system blockade) were administered after healing of acetic acid-induced ulcer. One percent methylcellulose solution was used as control.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In rats, nitric oxide blockade with L-NAME weakened the protective effect of BPC‑157 on gastric mucosa and its molecular effects.

    In plain wordsIn rats, blocking nitric oxide weakened the stomach-protecting effect of BPC‑157.

    Peptide
    BPC-157
    Outcome
    Not applicableEffect of L-NAME on the protective and molecular effects of BPC 157
    Study

    Sprague Dawley ratsn: not reported in source

    Clopidogrel-induced recurrence of acetic acid-induced gastric ulcer
    Comparator
    BPC 157 without L-NAME
    Outcome group
    Receptor activity and mechanism · Gastrointestinal
    Studied dose
    Dose not stated

    Source sentences

    Summary
    However, NO blockade L-NAME weakened the protective effect and thus the molecular effects of BPC 157 on gastric mucosa.
    1 context sentence
    Summary · context
    We used acetic acid to induce gastric ulcer in Sprague Dawley rats. Clopidogrel alone or in combination with BPC 157 or L-NAME (nitric oxide system blockade) were administered after healing of acetic acid-induced ulcer. One percent methylcellulose solution was used as control.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    9 Oct 2026, 12:39 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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