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Study · Animal study (in vivo) · rat · 2021

8 results

Humanin regulates oxidative stress in the ovaries of polycystic ovary syndrome patients via the Keap1/Nrf2 pathway.

Wang Y, Li N, Zeng Z, Tang L, Zhao S, Zhou F, Zhou L, Xia W, Zhu C, Rao M

Molecular human reproduction1 Feb 2021Cited by 61 (Europe PMC)

PMID33337472 (opens in a new tab)DOI10.1093/molehr/gaaa081 (opens in a new tab)PepBankPUB-33337472
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

6 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DHEA-induced PCOS, exogenous humanin supplementation attenuated body weight gain.

    In plain wordsIn rats with PCOS, added humanin reduced weight gain.

    Peptide
    Humanin
    Outcome
    DecreaseBody weight gain in PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Body weight · Metabolic and weight
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous humanin supplementation significantly attenuated body weight gain
    1 context sentence
    Summary · context
    Dehydroepiandrosterone-induced rat PCOS models, and vitamin K3-induced OS COV434 cell lines were applied to investigate the mechanism.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DHEA-induced PCOS, exogenous humanin supplementation attenuated ovarian morphological abnormalities.

    In plain wordsIn rats with PCOS, added humanin reduced changes in the shape of the ovary.

    Peptide
    Humanin
    Outcome
    DecreaseOvarian morphological abnormalities in PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous humanin supplementation significantly attenuated body weight gain, ovarian morphological abnormalities, endocrinological disorders and ovarian and systemic OS in PCOS rat models.
    1 context sentence
    Summary · context
    Dehydroepiandrosterone-induced rat PCOS models, and vitamin K3-induced OS COV434 cell lines were applied to investigate the mechanism.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DHEA-induced PCOS, exogenous humanin supplementation attenuated endocrinological disorders.

    In plain wordsIn rats with PCOS, added humanin reduced hormone problems.

    Peptide
    Humanin
    Outcome
    DecreaseEndocrinological disorders in PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Sex hormones and fertility · Endocrine and hormones
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous humanin supplementation significantly attenuated body weight gain, ovarian morphological abnormalities, endocrinological disorders and ovarian and systemic OS in PCOS rat models.
    1 context sentence
    Summary · context
    Dehydroepiandrosterone-induced rat PCOS models, and vitamin K3-induced OS COV434 cell lines were applied to investigate the mechanism.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DHEA-induced PCOS, exogenous humanin supplementation attenuated ovarian oxidative stress.

    In plain wordsIn rats with PCOS, added humanin reduced oxidative stress in the ovary.

    Peptide
    Humanin
    Outcome
    DecreaseOvarian oxidative stress in PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Oxidative stress · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous humanin supplementation significantly attenuated body weight gain, ovarian morphological abnormalities, endocrinological disorders and ovarian and systemic OS in PCOS rat models.
    1 context sentence
    Summary · context
    Dehydroepiandrosterone-induced rat PCOS models, and vitamin K3-induced OS COV434 cell lines were applied to investigate the mechanism.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In rats with DHEA-induced PCOS, exogenous humanin supplementation attenuated systemic oxidative stress.

    In plain wordsIn rats with PCOS, added humanin reduced oxidative stress across the body.

    Peptide
    Humanin
    Outcome
    DecreaseSystemic oxidative stress in PCOS rats
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Exogenous humanin supplementation significantly attenuated body weight gain, ovarian morphological abnormalities, endocrinological disorders and ovarian and systemic OS in PCOS rat models.
    1 context sentence
    Summary · context
    Dehydroepiandrosterone-induced rat PCOS models, and vitamin K3-induced OS COV434 cell lines were applied to investigate the mechanism.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In the PCOS rat model, the attenuating effect of humanin involved modulation of the Keap1/Nrf2 signalling pathway.

    In plain wordsIn rats with PCOS, the benefit of added humanin involved a cell signalling path called Keap1/Nrf2.

    Peptide
    Humanin
    Outcome
    Not applicableKeap1/Nrf2 pathway modulation
    Study

    Ratn: not reported in source

    Dehydroepiandrosterone-induced PCOS rat model
    Outcome group
    Receptor activity and mechanism · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Our study further demonstrated that this attenuation effect was involved in the modulation of the Kelch-like ECH-associated protein 1 (Keap1)/nuclear factor-erythroid 2-related factor 2 (Nrf2) signalling pathway.
    1 context sentence
    Summary · context
    Dehydroepiandrosterone-induced rat PCOS models, and vitamin K3-induced OS COV434 cell lines were applied to investigate the mechanism.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 07HumanEndogenous levelObservational studyOther

    In women with PCOS, humanin expression was significantly lower in the ovaries than in women without PCOS.

    In plain wordsWomen with PCOS had lower levels of the body's own humanin in the ovary than women without PCOS.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin expression in ovaries of PCOS patients
    Study

    n = 44

    Comparator
    Non-PCOS controls
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Humanin expression was significantly down-regulated in the ovaries of PCOS patients relative to those of non-PCOS patients.
    1 context sentence
    Summary · context
    Sixteen PCOS patients and 28 age- and BMI-matched controls undergoing IVF were recruited, and their serum, follicular fluid and GCs were collected for humanin analysis.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

  2. 08HumanEndogenous levelObservational studyOther

    In women with PCOS, decreased humanin expression in granulosa cells was associated with oxidative imbalance.

    In plain wordsIn women with PCOS, lower levels of the body's own humanin in ovary cells were linked to oxidative imbalance.

    Peptide
    Humanin
    Outcome
    DecreaseHumanin expression and oxidative imbalance in granulosa cells
    Study

    n = 44

    Outcome group
    Oxidative stress · Reproductive and sexual health

    Source sentences

    Summary
    In summary, this study reported for the first time that decreased expression of humanin in the GCs was associated with oxidative imbalance in PCOS.
    1 context sentence
    Summary · context
    Sixteen PCOS patients and 28 age- and BMI-matched controls undergoing IVF were recruited, and their serum, follicular fluid and GCs were collected for humanin analysis.

    This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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