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Study · Not a test of the peptide alone · 2021

2 results

AMP-activated protein kinase (AMPK) signaling in GnRH neurons links energy status and reproduction.

Franssen D, Barroso A, Ruiz-Pino F, Vázquez MJ, García-Galiano D, Castellano JM, Onieva R, Ruiz-Cruz M, Poutanen M, Gaytán F, Diéguez C, Pinilla L, Lopez M, Roa J, Tena-Sempere M

Metabolism: clinical and experimental4 Dec 2020Cited by 28 (Europe PMC)

PMID33285180 (opens in a new tab)DOI10.1016/j.metabol.2020.154460 (opens in a new tab)PepBankPUB-33285180
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone2

In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Kisspeptin-10.

  1. 01AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    Prepubertal female GAMKO mice had exaggerated LH responses to kisspeptin‑10, which served as a challenge, compared with controls.

    In plain wordsIn mice, young females lacking AMPK in GnRH neurons showed a larger LH response to a kisspeptin‑10 challenge.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH response to kisspeptin-10 at prepubertal age in female GAMKO mice
    Study

    mousen: not reported in source

    GAMKO mice (AMPK α1 ablation in GnRH neurons)
    Comparator
    Control mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Female (but not male) GAMKO mice displayed earlier puberty onset and exaggerated LH (as surrogate marker of GnRH) responses to kisspeptin-10 at the prepubertal age.
    1 context sentence
    Summary · context
    GAMKO mice of both sexes were subjected to reproductive characterization, with attention to puberty and gonadotropic responses to kisspeptin and metabolic stress.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

  2. 02AnimalNot a test of Kisspeptin-10 aloneAnimal study (in vivo)Efficacy outcome

    Adult female GAMKO mice retained increased LH responsiveness to kisspeptin, which served as a challenge.

    In plain wordsIn mice, adult females lacking AMPK in GnRH neurons kept a larger LH response to a kisspeptin challenge.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseLH responsiveness to kisspeptin in adult female GAMKO mice
    Study

    mousen: not reported in source

    GAMKO mice (AMPK α1 ablation in GnRH neurons)
    Comparator
    Control mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In adulthood, GAMKO females retained increased LH responsiveness to kisspeptin
    1 context sentence
    Summary · context
    GAMKO mice of both sexes were subjected to reproductive characterization, with attention to puberty and gonadotropic responses to kisspeptin and metabolic stress.

    In this study, Kisspeptin-10 was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Kisspeptin-10.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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