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Study · Animal study (in vivo) · rat · 2020

4 results

Peptide ACTH4-7-PGP: Effects on Various Types of Pain and Pain-Induced Behavior in Rats after Systemic and Central Administration.

Severyanova LA, Kryukov AA, Plotnikov DV, Dolgintsev ME

Bulletin of experimental biology and medicine2 Dec 2020

PMID33263853 (opens in a new tab)DOI10.1007/s10517-020-05029-8 (opens in a new tab)PepBankPUB-33263853
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Semax increased pain sensitivity during thermal stimulation in the hot plate test.

    In plain wordsIn rats, Semax made animals more sensitive to heat pain in the hot plate test.

    Peptide
    Semax
    Outcome
    IncreasePain sensitivity in hot plate test
    Study

    ratn: not reported in source

    rats with different types of pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5-450 μg/kg intraperitoneal; 16-400 pg intracerebroventricular · intraperitoneal or intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    the peptide increased pain sensitivity and induced avoidance behavior during thermal stimulation
    1 context sentence
    Summary · context
    The effects of peptide ACTH4-7-PGP (Semax) were studied in 12 min after its intraperitoneal (in doses of 5, 15, 50, 150, and 450 μg/kg) or intracerebroventricular (in doses of 16, 40, and 400 pg) administration to rats with different types of pain and pain-induced behavior.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Semax induced avoidance behavior during thermal stimulation in the hot plate test.

    In plain wordsIn rats, Semax caused more avoidance behavior during heat stimulation in the hot plate test.

    Peptide
    Semax
    Outcome
    IncreaseAvoidance behavior in hot plate test
    Study

    ratn: not reported in source

    rats with different types of pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5-450 μg/kg intraperitoneal; 16-400 pg intracerebroventricular · intraperitoneal or intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    the peptide increased pain sensitivity and induced avoidance behavior during thermal stimulation
    1 context sentence
    Summary · context
    The effects of peptide ACTH4-7-PGP (Semax) were studied in 12 min after its intraperitoneal (in doses of 5, 15, 50, 150, and 450 μg/kg) or intracerebroventricular (in doses of 16, 40, and 400 pg) administration to rats with different types of pain and pain-induced behavior.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Semax had an analgesic effect during electrocutaneous stimulation of the paws (foot-shock model) and tail, more pronounced after central administration.

    In plain wordsIn rats, Semax reduced pain from electric stimulation of the paws and tail, more strongly when given into the brain.

    Peptide
    Semax
    Outcome
    DecreasePain sensitivity in electrocutaneous stimulation (foot-shock and tail)
    Study

    ratn: not reported in source

    rats with different types of pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5-450 μg/kg intraperitoneal; 16-400 pg intracerebroventricular · intraperitoneal or intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    had an analgesic effect (more pronounced after central administration) and weakened emotional-affective behavior in electrocutaneous stimulation of the paws (foot-shock model) and tail in rats
    1 context sentence
    Summary · context
    The effects of peptide ACTH4-7-PGP (Semax) were studied in 12 min after its intraperitoneal (in doses of 5, 15, 50, 150, and 450 μg/kg) or intracerebroventricular (in doses of 16, 40, and 400 pg) administration to rats with different types of pain and pain-induced behavior.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In rats, Semax weakened emotional-affective behavior during electrocutaneous stimulation of the paws (foot-shock model) and tail.

    In plain wordsIn rats, Semax weakened emotional reactions to electric stimulation of the paws and tail.

    Peptide
    Semax
    Outcome
    DecreaseEmotional-affective behavior in electrocutaneous stimulation
    Study

    ratn: not reported in source

    rats with different types of pain
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    5-450 μg/kg intraperitoneal; 16-400 pg intracerebroventricular · intraperitoneal or intracerebroventricularAs given in this study (rat).

    Source sentences

    Summary
    had an analgesic effect (more pronounced after central administration) and weakened emotional-affective behavior in electrocutaneous stimulation of the paws (foot-shock model) and tail in rats
    1 context sentence
    Summary · context
    The effects of peptide ACTH4-7-PGP (Semax) were studied in 12 min after its intraperitoneal (in doses of 5, 15, 50, 150, and 450 μg/kg) or intracerebroventricular (in doses of 16, 40, and 400 pg) administration to rats with different types of pain and pain-induced behavior.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 19:08 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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