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Study · Animal study (in vivo) · rat · 2020

5 results

Bowel adhesion and therapy with the stable gastric pentadecapeptide BPC 157, L-NAME and L-arginine in rats.

Cesar LB, Gojkovic S, Krezic I, Malekinusic D, Zizek H, Vuletic LB, Petrovic A, Pavlov KH, Drmic D, Kokot A, Vlainic J, Seiwerth S, Sikiric P

World journal of gastrointestinal pharmacology and therapeutics1 Nov 2020Cited by 14 (Europe PMC)

PMID33251034 (opens in a new tab)PMCIDPMC7667405 (opens in a new tab)DOI10.4292/wjgpt.v11.i5.93 (opens in a new tab)PepBankPUB-33251034
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In rats with peritoneal defects, BPC‑157 regimens went with abundant vascular vessels in and near the defect, which occurred rapidly.

    In plain wordsIn rats with peritoneal defects, BPC‑157 went with many blood vessels near the defect, which appeared quickly.

    Peptide
    BPC-157
    Outcome
    IncreaseVascular vessels near the defect
    Study

    ratn: not reported in source

    Rat parietal peritoneum excision with adhesion formation
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · abdominal bath or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    The recovery effect of the BPC 157 regimens goes with the presence of abundant vascular vessels in and near the defect, which occurs rapidly.
    1 context sentence
    Summary · context
    After parietal peritoneum excision with an underlying superficial layer of muscle tissue in rats, there is failed vasculature, and finally, increased adhesion formation.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats with pre-existing peritoneal adhesions, BPC‑157 given as post-treatment attenuated adhesions, with minimal or no adhesion.

    In plain wordsIn rats with existing adhesions, BPC‑157 given later led to fewer adhesions, with minimal or none.

    Peptide
    BPC-157
    Outcome
    DecreaseAdhesion formation with post-treatment
    Study

    ratn: not reported in source

    Rat parietal peritoneum excision with adhesion formation
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · intraperitoneal · Once daily from day 7As given in this study (rat).

    Source sentences

    Summary
    Lastly, also applied as post-treatment, BPC 157 creates attenuated adhesions, minimal or no adhesion.
    2 context sentences
    Summary · context
    As a postponed therapy to pre-existing adhesion (3), BPC 157 (10 µg/kg, 10 ng/kg intraperitoneally, 1 mL/rat) was given once daily since d 7.
    Summary · context
    After parietal peritoneum excision with an underlying superficial layer of muscle tissue in rats, there is failed vasculature, and finally, increased adhesion formation.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In rats with peritoneal defects, BPC‑157 kept its beneficial effect on adhesions when given with L-NAME, L-arginine or both.

    In plain wordsIn rats, BPC‑157 still worked against adhesions when given with L-NAME or L-arginine.

    Peptide
    BPC-157
    Outcome
    DecreaseAdhesion formation when given with NO-agents
    Study

    ratn: not reported in source

    Rat parietal peritoneum excision with adhesion formation
    Outcome group
    Wound healing · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · abdominal bath or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Importantly, BPC 157 maintains its beneficial effect also when given with NO-agents (L-NAME + BC 157; L-arginine + BPC 157; L-NAME + L-arginine + BPC 157).
    1 context sentence
    Summary · context
    After parietal peritoneum excision with an underlying superficial layer of muscle tissue in rats, there is failed vasculature, and finally, increased adhesion formation.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In rats with peritoneal adhesions, BPC‑157 application decreased the increased nitric oxide values in adhesion tissue.

    In plain wordsIn rats, BPC‑157 lowered the raised nitric oxide levels in adhesion tissue.

    Peptide
    BPC-157
    Outcome
    DecreaseAdhesion tissue NO values
    Study

    ratn: not reported in source

    Rat parietal peritoneum excision with adhesion formation
    Outcome group
    Oxidative stress · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · abdominal bath or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Finally, with respect to the increased NO- and MDA- values-adhesion tissue formation relation, unlike diverse effect of the NO-agents, the BPC 157 application effect regularly combines decrease on the increased NO- and MDA- values and the beneficial outcome (less adhesion formation).
    1 context sentence
    Summary · context
    After parietal peritoneum excision with an underlying superficial layer of muscle tissue in rats, there is failed vasculature, and finally, increased adhesion formation.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In rats with peritoneal adhesions, BPC‑157 application decreased the increased malondialdehyde values in adhesion tissue.

    In plain wordsIn rats, BPC‑157 lowered the raised malondialdehyde (an oxidative stress marker) levels in adhesion tissue.

    Peptide
    BPC-157
    Outcome
    DecreaseAdhesion tissue MDA values
    Study

    ratn: not reported in source

    Rat parietal peritoneum excision with adhesion formation
    Outcome group
    Oxidative stress · Gastrointestinal
    Studied dose
    10 µg/kg or 10 ng/kg · abdominal bath or intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Finally, with respect to the increased NO- and MDA- values-adhesion tissue formation relation, unlike diverse effect of the NO-agents, the BPC 157 application effect regularly combines decrease on the increased NO- and MDA- values and the beneficial outcome (less adhesion formation).
    1 context sentence
    Summary · context
    After parietal peritoneum excision with an underlying superficial layer of muscle tissue in rats, there is failed vasculature, and finally, increased adhesion formation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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