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Study · Non-randomized trial · n = 67 · 2020

10 results

[Developmental dysphasia in children: a comparison of the effectiveness of two modes of peptidergic nootropic therapy].

Zavadenko NN, Davydova LA, Suvorinova NY

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2020Cited by 2 (Europe PMC)

PMID33244956 (opens in a new tab)DOI10.17116/jnevro202012010138 (opens in a new tab)PepBankPUB-33244956
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study10

10 results from studies that gave the peptide. 10 results from people.

  1. 01HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, vocabulary at least doubled more often after two cortexin courses than after one course.

    In plain wordsIn children with developmental dysphasia, vocabulary at least doubled more often after two cortexin courses than after one course.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseVocabulary doubling responders after two courses versus one
    Study

    n = 67

    Comparator
    One cortexin course
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · Two courses at 1-month intervalsAs given in this study (human).

    Measurements

    Responders
    80%
    two courses
    Responders
    44.4%
    one course

    Source sentences

    Summary
    The increase ratio of the active vocabulary volume by 2 times or more was observed in group 2 (two courses of cortexin treatment) in 80.0% of patients (significant differences with groups 1 and 3, p<0.001), in 44.4% of group 1 (one course of cortexin), in 22.2% of the control group.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  2. 02HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, vocabulary at least doubled more often after two cortexin courses than without medication.

    In plain wordsIn children with developmental dysphasia, vocabulary at least doubled more often after two cortexin courses than without medication.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseVocabulary doubling responders after two courses versus control
    Study

    n = 67

    Comparator
    No medication
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · Two courses at 1-month intervalsAs given in this study (human).

    Measurements

    Responders
    80%
    two courses
    Responders
    22.2%
    control

    Source sentences

    Summary
    The increase ratio of the active vocabulary volume by 2 times or more was observed in group 2 (two courses of cortexin treatment) in 80.0% of patients (significant differences with groups 1 and 3, p<0.001), in 44.4% of group 1 (one course of cortexin), in 22.2% of the control group.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  3. 03HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, active vocabulary increased 2.8-fold after two cortexin courses versus 1.4-fold without medication.

    In plain wordsIn children with developmental dysphasia, vocabulary increased 2.8-fold after two cortexin courses versus 1.4-fold without medication.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseActive vocabulary increase after two courses
    Study

    n = 67

    Comparator
    No medication
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · Two courses at 1-month intervalsAs given in this study (human).

    Measurements

    Vocabulary increase
    2.8 fold
    two courses
    Vocabulary increase
    1.4 fold
    control

    Source sentences

    Summary
    Over a two-month period, the increase ratio in the active vocabulary and the number of uttered phrases in group 2 was 2.8 and 4.2 times, in group 1 2.3 and 3.6 times, respectively, in the control group it was only 1.4 and 1.5 times.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  4. 04HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, uttered phrases increased 4.2-fold after two cortexin courses versus 1.5-fold without medication.

    In plain wordsIn children with developmental dysphasia, uttered phrases increased 4.2-fold after two cortexin courses versus 1.5-fold without medication.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseUttered phrase increase after two courses
    Study

    n = 67

    Comparator
    No medication
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscular · Two courses at 1-month intervalsAs given in this study (human).

    Measurements

    Phrase increase
    4.2 fold
    two courses
    Phrase increase
    1.5 fold
    control

    Source sentences

    Summary
    Over a two-month period, the increase ratio in the active vocabulary and the number of uttered phrases in group 2 was 2.8 and 4.2 times, in group 1 2.3 and 3.6 times, respectively, in the control group it was only 1.4 and 1.5 times.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  5. 05HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, vocabulary increased 2.8-fold after two cortexin courses versus 2.3-fold after one course.

    In plain wordsIn children with developmental dysphasia, vocabulary increased 2.8-fold after two cortexin courses versus 2.3-fold after one course.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseActive vocabulary increase after two versus one course
    Study

    n = 67

    Comparator
    One cortexin course
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscular · Two courses at 1-month intervalsAs given in this study (human).

    Measurements

    Active vocabulary increase ratio
    2.8 fold
    two courses (group 2)
    Active vocabulary increase ratio
    2.3 fold
    one course (group 1)

    Source sentences

    Summary
    Over a two-month period, the increase ratio in the active vocabulary and the number of uttered phrases in group 2 was 2.8 and 4.2 times, in group 1 2.3 and 3.6 times, respectively, in the control group it was only 1.4 and 1.5 times.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  6. 06HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, uttered phrases increased 4.2-fold after two cortexin courses versus 3.6-fold after one course.

    In plain wordsIn children with developmental dysphasia, uttered phrases increased 4.2-fold after two cortexin courses versus 3.6-fold after one course.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseUttered phrase increase after two versus one course
    Study

    n = 67

    Comparator
    One cortexin course
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscular · Two courses at 1-month intervalsAs given in this study (human).

    Measurements

    Phrase increase ratio
    4.2 fold
    two courses (group 2)
    Phrase increase ratio
    3.6 fold
    one course (group 1)

    Source sentences

    Summary
    Over a two-month period, the increase ratio in the active vocabulary and the number of uttered phrases in group 2 was 2.8 and 4.2 times, in group 1 2.3 and 3.6 times, respectively, in the control group it was only 1.4 and 1.5 times.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  7. 07HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, active vocabulary volume was significantly larger after two cortexin courses than after one course.

    In plain wordsIn children with developmental dysphasia, vocabulary volume was larger after two cortexin courses than after one course.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseActive vocabulary volume
    Study

    n = 67

    Comparator
    One cortexin course
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscular · Two courses at 1-month intervalsAs given in this study (human).

    Measurements

    Vocabulary volume
    42.4 not stated
    two courses
    Vocabulary volume
    31.7 not stated
    one course

    Source sentences

    Summary
    Furthermore, the volume of active vocabulary in group 2 (42.4±3.6) became significantly larger (p=0.01) than in group 1 (31.7±5.6), although its initial values in group 1 (13.7±1.8) and group 2 (14.9±1.7) were similar.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  8. 08HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, vocabulary at least doubled in 44.4% after one cortexin course versus 22.2% without medication.

    In plain wordsIn children with developmental dysphasia, vocabulary at least doubled in 44.4% after one cortexin course versus 22.2% without medication.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseVocabulary doubling responders after one course
    Study

    n = 54

    Comparator
    No medication
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscular · 10 daysAs given in this study (human).

    Measurements

    Responders
    44.4%
    one course
    Responders
    22.2%
    control

    Source sentences

    Summary
    The increase ratio of the active vocabulary volume by 2 times or more was observed in group 2 (two courses of cortexin treatment) in 80.0% of patients (significant differences with groups 1 and 3, p<0.001), in 44.4% of group 1 (one course of cortexin), in 22.2% of the control group.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  9. 09HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, active vocabulary increased 2.3-fold after one cortexin course versus 1.4-fold without medication.

    In plain wordsIn children with developmental dysphasia, vocabulary increased 2.3-fold after one cortexin course versus 1.4-fold without medication.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseActive vocabulary increase after one course
    Study

    n = 54

    Comparator
    No medication
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscular · 10 daysAs given in this study (human).

    Measurements

    Vocabulary increase
    2.3 fold
    one course
    Vocabulary increase
    1.4 fold
    control

    Source sentences

    Summary
    Over a two-month period, the increase ratio in the active vocabulary and the number of uttered phrases in group 2 was 2.8 and 4.2 times, in group 1 2.3 and 3.6 times, respectively, in the control group it was only 1.4 and 1.5 times.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.
  10. 10HumanNon-randomized trialEfficacy outcome

    In children with developmental dysphasia, uttered phrases increased 3.6-fold after one cortexin course versus 1.5-fold without medication.

    In plain wordsIn children with developmental dysphasia, uttered phrases increased 3.6-fold after one cortexin course versus 1.5-fold without medication.

    Peptide
    Cortexin (cortical polypeptide complex)
    Outcome
    IncreaseUttered phrase increase after one course
    Study

    n = 54

    Comparator
    No medication
    Outcome group
    Cognition and memory · Nervous system and cognition
    Studied dose
    Dose not stated · intramuscular · 10 daysAs given in this study (human).

    Measurements

    Phrase increase
    3.6 fold
    one course
    Phrase increase
    1.5 fold
    control

    Source sentences

    Summary
    Over a two-month period, the increase ratio in the active vocabulary and the number of uttered phrases in group 2 was 2.8 and 4.2 times, in group 1 2.3 and 3.6 times, respectively, in the control group it was only 1.4 and 1.5 times.
    6 context sentences
    Summary · context
    To study the therapeutic efficacy of two treatment modes of peptidergic nootropic medication cortexin in children with developmental dysphasia aged 3-4 years.
    Summary · context
    In group 1 (27 patients), cortexin was administered once a day intramuscularly for 10 days.
    Summary · context
    After this course, the children were not prescribed drug therapy, a second examination was carried out 2 months after the start of treatment.
    Summary · context
    In group 2 (40 patients), two courses of cortexin were administered at 1-month intervals, and the children were also followed up for two months.
    Summary · context
    Control group 3 (27 patients) did not receive medication, but was also followed up for two months.
    Summary · context
    Before the study and two months later, speech development was assessed with special scales and questionnaires for parents.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:25 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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