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Study · In vitro (cells) · 2020

4 results

Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells.

Khavinson VK, Linkova NS, Kvetnoy IM, Polyakova VO, Drobintseva AO, Kvetnaia TV, Ivko OM

Bulletin of experimental biology and medicine25 Nov 2020Cited by 3 (Europe PMC)

PMID33237528 (opens in a new tab)PMCIDPMC7686446 (opens in a new tab)DOI10.1007/s10517-020-05016-z (opens in a new tab)PepBankPUB-33237528
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In human hematopoietic stem cells, thymalin reduced CD44 expression by 2-3 times.

    In plain wordsIn cells, thymalin reduced expression of the stem cell marker CD44.

    Peptide
    Thymalin
    Outcome
    DecreaseCD44 expression
    Study

    humann: not reported in source

    Human hematopoietic stem cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    CD44 expression reduction
    2 to 3 fold
    Human hematopoietic stem cells

    Source sentences

    Summary
    It was found that thymalin reduced the expression of CD44 (stem cell marker) and CD117 (molecule of the intermediate stage of HSC differentiation) by 2-3 times and increased the expression of CD28 (marker of mature T lymphocytes) by 6.8 times.
    1 context sentence
    Summary · context
    We studied the influence of thymalin on differentiation of human hematopoietic stem cells (HSC) and expression of CD28 molecule involved in the implementation of antiviral immunity in COVID-19 infection.
  2. 02LabIn vitro (cells)Mechanism

    In human hematopoietic stem cells, thymalin reduced CD117 expression by 2-3 times.

    In plain wordsIn cells, thymalin reduced expression of the differentiation marker CD117.

    Peptide
    Thymalin
    Outcome
    DecreaseCD117 expression
    Study

    humann: not reported in source

    Human hematopoietic stem cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    CD117 expression reduction
    2 to 3 fold
    Human hematopoietic stem cells

    Source sentences

    Summary
    It was found that thymalin reduced the expression of CD44 (stem cell marker) and CD117 (molecule of the intermediate stage of HSC differentiation) by 2-3 times and increased the expression of CD28 (marker of mature T lymphocytes) by 6.8 times.
    1 context sentence
    Summary · context
    We studied the influence of thymalin on differentiation of human hematopoietic stem cells (HSC) and expression of CD28 molecule involved in the implementation of antiviral immunity in COVID-19 infection.
  3. 03LabIn vitro (cells)Mechanism

    In human hematopoietic stem cells, thymalin increased CD28 expression by 6.8 times.

    In plain wordsIn cells, thymalin increased expression of the mature T-cell marker CD28.

    Peptide
    Thymalin
    Outcome
    IncreaseCD28 expression
    Study

    humann: not reported in source

    Human hematopoietic stem cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Measurements

    CD28 expression increase
    6.8 fold
    Human hematopoietic stem cells

    Source sentences

    Summary
    It was found that thymalin reduced the expression of CD44 (stem cell marker) and CD117 (molecule of the intermediate stage of HSC differentiation) by 2-3 times and increased the expression of CD28 (marker of mature T lymphocytes) by 6.8 times.
    1 context sentence
    Summary · context
    We studied the influence of thymalin on differentiation of human hematopoietic stem cells (HSC) and expression of CD28 molecule involved in the implementation of antiviral immunity in COVID-19 infection.
  4. 04LabIn vitro (cells)Mechanism

    In human hematopoietic stem cells, marker changes indirectly indicated that thymalin stimulated differentiation of CD117-positive cells into mature CD28-positive T lymphocytes.

    In plain wordsIn cells, marker changes indirectly indicated that thymalin promoted development into mature T lymphocytes.

    Peptide
    Thymalin
    Outcome
    IncreaseDifferentiation into mature T lymphocytes
    Study

    humann: not reported in source

    Human hematopoietic stem cells
    Outcome group
    Immune response · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    This indirectly indicates that thymalin stimulated differentiation of CD117+ cells into mature CD28+T lymphocytes.
    2 context sentences
    Summary · context
    It was found that thymalin reduced the expression of CD44 (stem cell marker) and CD117 (molecule of the intermediate stage of HSC differentiation) by 2-3 times and increased the expression of CD28 (marker of mature T lymphocytes) by 6.8 times.
    Summary · context
    We studied the influence of thymalin on differentiation of human hematopoietic stem cells (HSC) and expression of CD28 molecule involved in the implementation of antiviral immunity in COVID-19 infection.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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