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Study · Observational study · 2020

3 results

Lipid peroxidation aggravates anti-tuberculosis drug-induced liver injury: Evidence of ferroptosis induction.

Pan Y, Tang P, Cao J, Song Q, Zhu L, Ma S, Zhang J

Biochemical and biophysical research communications26 Oct 2020Cited by 43 (Europe PMC)

PMID33121683 (opens in a new tab)DOI10.1016/j.bbrc.2020.09.140 (opens in a new tab)PepBankPUB-33121683
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 1 result from people.

  1. 01HumanObservational studyEfficacy outcome

    In tuberculosis patients receiving INH and RFP, glutathione intake was associated with a negative ATB-DILI rate.

    In plain wordsIn tuberculosis patients receiving INH and RFP, glutathione intake was linked to a negative rate of drug-induced liver injury.

    Peptide
    Glutathione
    Outcome
    DecreaseATB-DILI rate
    Study

    n: not reported in source

    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Retrospective study of tuberculosis patients who underwent INH and RFP treatment also revealed an association between the intake of glutathione and a negative ATB-DILI rate.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with anti-tuberculosis drug-induced liver injury, glutathione supplementation significantly reduced lipid peroxidation.

    In plain wordsIn mice with liver injury from tuberculosis drugs, glutathione supplementation reduced lipid peroxidation.

    Peptide
    Glutathione
    Outcome
    DecreaseLipid peroxidation
    Study

    mousen: not reported in source

    Anti-tuberculosis drug-induced liver injury
    Outcome group
    Oxidative stress · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    And glutathione supplementation significantly reduced the level of lipid peroxidation and the risk of liver damage.
    1 context sentence
    Summary · context
    Morphology of ferroptosis was discovered in ATB-DILI mouse livers by transmission electron microscopy.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice with anti-tuberculosis drug-induced liver injury, glutathione supplementation significantly reduced the risk of liver damage.

    In plain wordsIn mice with liver injury from tuberculosis drugs, glutathione supplementation reduced the risk of liver damage.

    Peptide
    Glutathione
    Outcome
    DecreaseLiver damage risk
    Study

    mousen: not reported in source

    Anti-tuberculosis drug-induced liver injury
    Outcome group
    Liver fat and liver function · Liver
    Studied dose
    Dose not stated

    Source sentences

    Summary
    And glutathione supplementation significantly reduced the level of lipid peroxidation and the risk of liver damage.
    1 context sentence
    Summary · context
    Morphology of ferroptosis was discovered in ATB-DILI mouse livers by transmission electron microscopy.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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