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Study · In vitro (cells) · 2020

3 results

Involvement of the mitochondrial nuclease EndoG in the regulation of cell proliferation through the control of reactive oxygen species.

Blasco N, Beà A, Barés G, Girón C, Navaridas R, Irazoki A, López-Lluch G, Zorzano A, Dolcet X, Llovera M, Sanchis D

Redox biology24 Sept 2020Cited by 17 (Europe PMC)

PMID33032073 (opens in a new tab)PMCIDPMC7552104 (opens in a new tab)DOI10.1016/j.redox.2020.101736 (opens in a new tab)PepBankPUB-33032073
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Mechanism

    In EndoG-deficient cells, addition of the micropeptide humanin restored AKT phosphorylation.

    In plain wordsIn cells lacking EndoG, added humanin restored AKT phosphorylation, a growth signal.

    Peptide
    Humanin
    Outcome
    IncreaseAKT phosphorylation
    Study

    n: not reported in source

    EndoG-deficient cells
    Outcome group
    Receptor activity and mechanism · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Addition of the micropeptide Humanin to EndoG-deficient cells restored AKT phosphorylation and proliferation without lowering ROS levels.
  2. 02LabIn vitro (cells)Efficacy outcome

    In EndoG-deficient cells, addition of the micropeptide humanin restored cell proliferation.

    In plain wordsIn cells lacking EndoG, added humanin restored cell growth.

    Peptide
    Humanin
    Outcome
    IncreaseCell proliferation
    Study

    n: not reported in source

    EndoG-deficient cells
    Outcome group
    Cell proliferation and differentiation · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Addition of the micropeptide Humanin to EndoG-deficient cells restored AKT phosphorylation and proliferation without lowering ROS levels.
  3. 03LabIn vitro (cells)Mechanism

    In EndoG-deficient cells, addition of the micropeptide humanin did not lower reactive oxygen species levels.

    In plain wordsIn cells lacking EndoG, added humanin did not lower reactive oxygen species.

    Peptide
    Humanin
    Outcome
    No significant changeROS levels
    Study

    n: not reported in source

    EndoG-deficient cells
    Outcome group
    Oxidative stress · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Addition of the micropeptide Humanin to EndoG-deficient cells restored AKT phosphorylation and proliferation without lowering ROS levels.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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