In diabetic TallyHO/JngJ mice, SS31 treatment reduced mitochondrial dysfunction.
In plain wordsIn diabetic mice, SS31 reduced mitochondrial dysfunction.
- Peptide
- Elamipretide (SS-31)
- Outcome
- DecreaseMitochondrial dysfunction (H2O2 production, lipid peroxidation, ATP production)
- Study
mousen: not reported in source
Diabetic TallyHO/JngJ mice (SWR/J non-diabetic strain as control)- Comparator
- Untreated diabetic TH mice
- Outcome group
- Mitochondrial function · Metabolic and weight
- Studied dose
- Dose not stated · intraperitoneal · 4 weeksAs given in this study (mouse).
Source sentences
However, treatment of animals with SS31 reduced mitochondrial dysfunction and restored most of the mitochondrial functions and mitochondrial dynamics processes to near normal in TH mice.
3 context sentences(design, population, supporting numbers)
This study aimed to investigate the possible mitochondrial alterations in the pancreas induced by hyperglycemia in diabetes.
We divided 24-week-old TH and SWR/J mice into 3 groups: controls, diabetic TH mice, and diabetic TH mice treated with SS31 peptide.
After the treatment of male TH mice with SS31, intraperitoneally, for 4 weeks, we studied mitochondrial dynamics, biogenesis, and function.