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Study · Randomized controlled trial · n = 160 · 2021

8 results

Comparative study between single versus dual trigger for poor responders in GnRH-antagonist ICSI cycles: A randomized controlled study.

Maged AM, Ragab MA, Shohayeb A, Saber W, Ekladious S, Hussein EA, El-Mazny A, Hany A

International journal of gynaecology and obstetrics: the official organ of the International Federation of Gynaecology and Obstetrics22 Oct 2020Cited by 28 (Europe PMC)

PMID33011968 (opens in a new tab)DOI10.1002/ijgo.13405 (opens in a new tab)PepBankPUB-33011968
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. 8 results from people.

  1. 01HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG increased retrieved oocytes versus hCG alone.

    In plain wordsAdding triptorelin to hCG increased retrieved eggs compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseRetrieved oocytes
    Study

    n = 160

    Comparator
    hCG alone
    Analysis
    Primary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Retrieved oocytes
    5.3 oocytes
    dual trigger
    Retrieved oocytes
    4.5 oocytes
    hCG alone

    Source sentences

    Summary
    Dual triggering was associated with higher number of retrieved oocytes (5.3 ± 1.9 vs 4.5 ± 2.4, P=0.014)
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.
  2. 02HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG increased metaphase II oocytes versus hCG alone.

    In plain wordsAdding triptorelin to hCG increased mature eggs compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseMetaphase II oocytes
    Study

    n = 160

    Comparator
    hCG alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Metaphase II oocytes
    3.8 oocytes
    dual trigger
    Metaphase II oocytes
    3.1 oocytes
    hCG alone

    Source sentences

    Summary
    metaphase II oocytes (3.8 ± 1.4 vs 3.1 ± 1.7, P=0.004)
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.
  3. 03HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG increased total embryos versus hCG alone.

    In plain wordsAdding triptorelin to hCG increased total embryos compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseTotal embryos
    Study

    n = 160

    Comparator
    hCG alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Total embryos
    2.7 embryos
    dual trigger
    Total embryos
    1.9 embryos
    hCG alone

    Source sentences

    Summary
    total and grade 1 embryos (2.7 ± 1.1 and 2.3 ± 1.0 vs 1.9 ± 1.2 and 1.1 ± 0.2, P=0.001 and 0.021 respectively)
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.
  4. 04HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG increased grade 1 embryos versus hCG alone.

    In plain wordsAdding triptorelin to hCG increased grade 1 embryos compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseGrade 1 embryos
    Study

    n = 160

    Comparator
    hCG alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Grade 1 embryos
    2.3 embryos
    dual trigger
    Grade 1 embryos
    1.1 embryos
    hCG alone

    Source sentences

    Summary
    total and grade 1 embryos (2.7 ± 1.1 and 2.3 ± 1.0 vs 1.9 ± 1.2 and 1.1 ± 0.2, P=0.001 and 0.021 respectively)
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.
  5. 05HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG reduced cancellation rates versus hCG alone.

    In plain wordsAdding triptorelin to hCG reduced cancellations compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    DecreaseCancellation rate
    Study

    n = 160

    Comparator
    hCG alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Cancellation rate
    7.5%
    dual trigger
    Cancellation rate
    20%
    hCG alone

    Source sentences

    Summary
    and lower cancellation rate (7.5% vs 20%, P=0.037) compared with single triggering.
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.
  6. 06HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG increased chemical pregnancy rates versus hCG alone.

    In plain wordsAdding triptorelin to hCG increased chemical pregnancy rates compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseChemical pregnancy rate
    Study

    n = 160

    Comparator
    hCG alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Chemical pregnancy rate
    25%
    dual trigger
    Chemical pregnancy rate
    11.3%
    hCG alone

    Source sentences

    Summary
    There were significantly higher chemical (25% vs 11.3%, P=0.039) and clinical (22.5% vs 8.8%, P=0.028) pregnancy rates in women with dual triggering compared with those with single triggering.
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.
  7. 07HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG increased clinical pregnancy rates versus hCG alone.

    In plain wordsAdding triptorelin to hCG increased clinical pregnancy rates compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseClinical pregnancy rate
    Study

    n = 160

    Comparator
    hCG alone
    Analysis
    Secondary
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Clinical pregnancy rate
    22.5%
    dual trigger
    Clinical pregnancy rate
    8.8%
    hCG alone

    Source sentences

    Summary
    There were significantly higher chemical (25% vs 11.3%, P=0.039) and clinical (22.5% vs 8.8%, P=0.028) pregnancy rates in women with dual triggering compared with those with single triggering.
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.
  8. 08HumanRandomized controlled trialEfficacy outcome

    In poor ovarian responders, adding triptorelin to hCG increased transferred embryos versus hCG alone.

    In plain wordsAdding triptorelin to hCG increased transferred embryos compared with hCG alone in poor ovarian responders.

    Peptide
    Triptorelin (Trelstar, Decapeptyl)
    Outcome
    IncreaseTransferred embryos
    Study

    n = 160

    Comparator
    hCG alone
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    0.2 mgAs given in this study (human).

    Measurements

    Transferred embryos
    2.2 embryos
    dual trigger
    Transferred embryos
    1.6 embryos
    hCG alone

    Source sentences

    Summary
    and transferred embryos (2.2 ± 0.9 vs 1.6 ± 0.9, P=0.043,
    2 context sentences
    Summary · context
    A randomized controlled trial included poor ovarian responders indicated for ICSI using a GnRH-antagonist protocol.
    Summary · context
    They were divided equally into two groups: group I received 10 000 units of hCG plus 0.2 mg of triptorelin while group II received 10 000 units of hCG only for triggering of ovulation.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 4NCT04008966

Comparative Study Between Single Versus Dual Trigger for Poor Responders in GnRH-antagonist ICSI Cycles

Cairo Universityn = 16020 Jul 2016 to 1 Jul 2019

Assisted Reproduction

Trial pageClinicalTrials.govUpdated 5 Jul 2019

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    22 Oct 2026, 02:26 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 18:59 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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