[Comparative study of protective effects of Cortexin, Cerebrolysin and Actovegin on memory impairment, cerebral circulation and morphological changes in the hippocampus of rats with chronic brain ischemia].

Tyurenkov IN, Kurkin DV, Kalatanova AV, Dorotenko AR, Bakulin DA, Morkovin EI, Verholyak DV, Gorbunova YV, Gorbunova YV, Atapina NV, Smirnov AV, Schmidt MV

Zhurnal nevrologii i psikhiatrii imeni S.S. Korsakova1 Jan 2020Cited by 7 (Europe PMC)

PMID32929929DOI10.17116/jnevro202012008183PepBankPUB-32929929

Publisher page PubMedAsk about this study

Jump to 11 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study11

11 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, Cerebrolysin had almost no effect on cerebral blood flow.
In plain wordsIn rats with chronic brain ischemia, Cerebrolysin had almost no effect on brain blood flow.
Peptide
Cerebrolysin
Outcome
No significant changeCerebral blood flow
Study
ratn: not reported in source
Chronic brain ischemia caused by common carotid artery stenosis
Outcome group
Cerebral blood flow · Nervous system and cognition
Studied dose
2.5 or 7.5 ml/kg · two 10-day courses with 10 days of treatment breakAs given in this study (rat).
Source sentences
Summary
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992901
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, Cerebrolysin improved memory formation in the Morris water maze.
In plain wordsIn rats with chronic brain ischemia, Cerebrolysin improved memory formation in a water maze.
Peptide
Cerebrolysin
Outcome
IncreaseMemory formation
Study
ratn: not reported in source
Chronic brain ischemia caused by common carotid artery stenosis
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5 or 7.5 ml/kg · two 10-day courses with 10 days of treatment breakAs given in this study (rat).
Source sentences
Summary
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992902
03AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, Cerebrolysin improved memory retrieval in the Morris water maze.
In plain wordsIn rats with chronic brain ischemia, Cerebrolysin improved memory retrieval in a water maze.
Peptide
Cerebrolysin
Outcome
IncreaseMemory retrieval
Study
ratn: not reported in source
Chronic brain ischemia caused by common carotid artery stenosis
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5 or 7.5 ml/kg · two 10-day courses with 10 days of treatment breakAs given in this study (rat).
Source sentences
Summary
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992903
04AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, the memory treatment effect was comparable between Cerebrolysin and Cortexin.
In plain wordsIn rats with chronic brain ischemia, memory effects were comparable between Cerebrolysin and Cortexin.
Peptide
Cerebrolysin
Outcome
No significant changeMemory effect compared with Cortexin
Study
ratn: not reported in source
Chronic brain ischemia caused by common carotid artery stenosis
Comparator
Cortexin
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5 or 7.5 ml/kg · two 10-day courses with 10 days of treatment breakAs given in this study (rat).
Source sentences
Summary
The treatment effect was comparable for both drugs and persisted after 10 days of treatment break.
3 context sentences(design, population, supporting numbers)
Summary · context
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992904
05AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, the Cerebrolysin treatment effect persisted after the treatment break.
In plain wordsIn rats with chronic brain ischemia, the Cerebrolysin treatment effect persisted after the treatment break.
Peptide
Cerebrolysin
Outcome
IncreasePersistence of memory effect
Study
ratn: not reported in source
Chronic brain ischemia caused by common carotid artery stenosis
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
2.5 or 7.5 ml/kg · two 10-day courses with 10 days of treatment breakAs given in this study (rat).
Source sentences
Summary
The treatment effect was comparable for both drugs and persisted after 10 days of treatment break.
3 context sentences(design, population, supporting numbers)
Summary · context
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992905
06AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, morphological assessment after treatment showed less severe hippocampal pathological changes.
In plain wordsIn rats with chronic brain ischemia, assessment after Cerebrolysin treatment showed less severe hippocampal damage.
Peptide
Cerebrolysin
Outcome
DecreaseHippocampal pathological changes
Study
ratn: not reported in source
Chronic brain ischemia caused by common carotid artery stenosis
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
Dose not stated · two 10-day courses with 10 days of treatment breakAs given in this study (rat).
Source sentences
Summary
Morphological assessment showed a decrease in the severity of pathological changes in the hippocampal regions.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992906
07AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, Cortexin had almost no effect on cerebral blood flow.
In plain wordsIn rats with chronic brain ischemia, Cortexin had almost no effect on brain blood flow.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
No significant changeCerebral blood flow
Study
ratn: not reported in source
Chronic brain ischemia after common carotid artery stenosis
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 and 3 mg/kg · two 10-day courses with a 10-day breakAs given in this study (rat).
Source sentences
Summary
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
2 context sentences(design, population, supporting numbers)
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992907
08AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, Cortexin improved memory formation in the Morris water maze.
In plain wordsIn rats with chronic brain ischemia, Cortexin improved memory formation in the Morris water maze.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseMemory formation
Study
ratn: not reported in source
Chronic brain ischemia after common carotid artery stenosis
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1 and 3 mg/kg · two 10-day courses with a 10-day breakAs given in this study (rat).
Source sentences
Summary
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
3 context sentences(design, population, supporting numbers)
Summary · context
The treatment effect was comparable for both drugs and persisted after 10 days of treatment break.
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992908
09AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, Cortexin improved memory retrieval in the Morris water maze.
In plain wordsIn rats with chronic brain ischemia, Cortexin improved memory retrieval in the Morris water maze.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
IncreaseMemory retrieval
Study
ratn: not reported in source
Chronic brain ischemia after common carotid artery stenosis
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1 and 3 mg/kg · two 10-day courses with a 10-day breakAs given in this study (rat).
Source sentences
Summary
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
3 context sentences(design, population, supporting numbers)
Summary · context
The treatment effect was comparable for both drugs and persisted after 10 days of treatment break.
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992909
10AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, Cortexin and Cerebrolysin had comparable memory effects that persisted through the treatment break.
In plain wordsIn rats with chronic brain ischemia, Cortexin and Cerebrolysin had comparable memory effects that persisted through the treatment break.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
No significant changeMemory treatment effect versus Cerebrolysin
Study
ratn: not reported in source
Chronic brain ischemia after common carotid artery stenosis
Comparator
Cerebrolysin
Outcome group
Cognition and memory · Nervous system and cognition
Studied dose
1 and 3 mg/kg · two 10-day courses with a 10-day breakAs given in this study (rat).
Source sentences
Summary
The treatment effect was comparable for both drugs and persisted after 10 days of treatment break.
3 context sentences(design, population, supporting numbers)
Summary · context
Administration of cortexin (1 and 3 mg/kg) and cerebrolysin (2.5 and 7.5 ml/kg) to rats with chronic brain ischemia had almost no effect on cerebral blood flow, but contributed to the improvement in memory formation and retrieval processes in the Morris water maze.
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Report a problemFND-3292992910
11AnimalAnimal study (in vivo)Efficacy outcome
In rats with chronic brain ischemia, treatment with Cortexin reduced the severity of hippocampal pathological changes.
In plain wordsIn rats with chronic brain ischemia, Cortexin treatment reduced hippocampal damage.
Peptide
Cortexin (cortical polypeptide complex)
Outcome
DecreaseHippocampal pathological changes
Study
ratn: not reported in source
Chronic brain ischemia after common carotid artery stenosis
Outcome group
Neuroprotection · Nervous system and cognition
Studied dose
1 and 3 mg/kg · two 10-day courses with a 10-day breakAs given in this study (rat).
Source sentences
Summary
Morphological assessment showed a decrease in the severity of pathological changes in the hippocampal regions.
2 context sentences(design, population, supporting numbers)
Summary · context
Animals received cortexin (0,3; 1 or 3 mg/kg), cerebrolysin (0,8; 2,5 or 7,5 ml/kg) and actovegin (5 ml/kg) in two 10-day courses with 10 days of treatment break.
Summary · context
The study was conducted using male rats with chronic brain ischemia caused by stenosis of the common carotid arteries by 50%.
Report a problemFND-3292992911

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 3Current
21 Oct 2026, 18:59 UTC
Study data updated · source update from Europe PMC
Version 2
14 Oct 2026, 05:02 UTC
Study results updated
Version 1
14 Oct 2026, 01:46 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

Journal Article

MeSH terms

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.