Skip to content

Study · In vitro (cells) · 2020

8 results

Humanin Ameliorates Free Fatty Acid-Induced Endothelial Inflammation by Suppressing the NLRP3 Inflammasome.

Li W, Zhang D, Yuan W, Wang C, Huang Q, Luo J

ACS omega26 Aug 2020Cited by 22 (Europe PMC)

PMID32923762 (opens in a new tab)PMCIDPMC7482084 (opens in a new tab)DOI10.1021/acsomega.0c01778 (opens in a new tab)PepBankPUB-32923762
Source linkPubMedAsk about this study
Jump to 8 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Efficacy outcome

    In human aortic endothelial cells, humanin inhibited free fatty acid-induced lactate dehydrogenase release, showing protection against cell death.

    In plain wordsIn human blood vessel cells, humanin reduced cell death caused by free fatty acids.

    Peptide
    Humanin
    Outcome
    DecreaseFFA-induced lactate dehydrogenase release
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Cell viability and death · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, treatment with humanin inhibited FFA-induced lactate dehydrogenase release, thereby demonstrating a protective capacity against cell death.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.
  2. 02LabIn vitro (cells)Efficacy outcome

    In human aortic endothelial cells exposed to free fatty acid, humanin suppressed oxidative stress by downregulating reactive oxygen species.

    In plain wordsIn human blood vessel cells, humanin lowered reactive oxygen species caused by free fatty acids.

    Peptide
    Humanin
    Outcome
    DecreaseReactive oxygen species expression
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin also suppressed oxidative stress by downregulating the expression of reactive oxygen species and NOX2.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.
  3. 03LabIn vitro (cells)Efficacy outcome

    In human aortic endothelial cells exposed to free fatty acid, humanin downregulated the expression of NOX2.

    In plain wordsIn human blood vessel cells, humanin lowered NOX2, an enzyme linked to oxidative stress.

    Peptide
    Humanin
    Outcome
    DecreaseNOX2 expression
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Oxidative stress · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Humanin also suppressed oxidative stress by downregulating the expression of reactive oxygen species and NOX2.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.
  4. 04LabIn vitro (cells)Efficacy outcome

    In human aortic endothelial cells exposed to free fatty acid, humanin reduced NLRP3.

    In plain wordsIn human blood vessel cells, humanin lowered NLRP3, a part of an inflammation-driving complex.

    Peptide
    Humanin
    Outcome
    DecreaseNLRP3 level
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, humanin reduced NLRP3 and p10 and rescued FFA-induced dysfunction of adenosine monophosphate-activated protein kinase.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.
  5. 05LabIn vitro (cells)Efficacy outcome

    In human aortic endothelial cells exposed to free fatty acid, humanin reduced p10.

    In plain wordsIn human blood vessel cells, humanin lowered p10, an inflammation-related protein fragment.

    Peptide
    Humanin
    Outcome
    Decreasep10 level
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, humanin reduced NLRP3 and p10 and rescued FFA-induced dysfunction of adenosine monophosphate-activated protein kinase.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.
  6. 06LabIn vitro (cells)Mechanism

    In human aortic endothelial cells exposed to free fatty acid, humanin rescued the free fatty acid-induced dysfunction of AMP-activated protein kinase.

    In plain wordsIn human blood vessel cells, humanin restored AMPK function that free fatty acids had disrupted.

    Peptide
    Humanin
    Outcome
    IncreaseAMPK function
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Notably, humanin reduced NLRP3 and p10 and rescued FFA-induced dysfunction of adenosine monophosphate-activated protein kinase.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.
  7. 07LabIn vitro (cells)Efficacy outcome

    In human aortic endothelial cells exposed to free fatty acid, humanin inhibited the expression of IL-1β.

    In plain wordsIn human blood vessel cells, humanin lowered the inflammation signal IL-1β.

    Peptide
    Humanin
    Outcome
    DecreaseIL-1β expression
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consequently, humanin inhibited the expression of IL-1β and IL-18.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.
  8. 08LabIn vitro (cells)Efficacy outcome

    In human aortic endothelial cells exposed to free fatty acid, humanin inhibited the expression of IL-18.

    In plain wordsIn human blood vessel cells, humanin lowered the inflammation signal IL-18.

    Peptide
    Humanin
    Outcome
    DecreaseIL-18 expression
    Study

    humann: not reported in source

    Human aortic endothelial cells exposed to free fatty acid
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Consequently, humanin inhibited the expression of IL-1β and IL-18.
    1 context sentence
    Summary · context
    Here, we investigated the molecular mechanisms whereby humanin was found to exert protective effects in human aortic endothelial cells (HAECs) against FFA-caused endothelial injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

PepBank is a research reference. Talk to a doctor before you use any peptide.