In immature rabbits, the tested drugs, including Cortexin, reduced but did not eliminate netromycin ototoxicity compared with netromycin alone.
In plain wordsIn rabbits, tested drugs including Cortexin reduced but did not eliminate netromycin hearing toxicity compared with netromycin alone.
- Outcome
- DecreaseOtotoxicity severity
- Study
rabbitn: not reported in source
Immature rabbits with an immature hearing organ- Comparator
- Netromycin alone
- Outcome group
- Neuroprotection · Nervous system and cognition
Source sentences
It was found that the administered drugs produced an otoprotective effect and reduced the severity, but did not eliminate the ototoxic effect.
2 context sentences(design, population, supporting numbers)
The experiments were carried out on immature rabbits with an immature hearing organ.
The auditory function was assessed by DPOAE and ABR methods in intact animals and rabbits treated with therapeutic doses of netromycin alone or in combination with the drugs that normalize metabolic processes in the brain (Cortexin, Cogitum, Elkar, vitamin B2, ATP, and cocarboxylase).
In this study, Cortexin (cortical polypeptide complex) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Cortexin (cortical polypeptide complex).