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Study · Animal study (in vivo) · rat · 2021

2 results

Ghrelin receptor agonist hexarelin attenuates antinociceptive tolerance to morphine in rats.

Baser T, Ozdemir E, Filiz AK, Taskiran AS, Gursoy S

Canadian journal of physiology and pharmacology5 Sept 2020Cited by 7 (Europe PMC)

PMID32893668 (opens in a new tab)DOI10.1139/cjpp-2020-0218 (opens in a new tab)PepBankPUB-32893668
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In morphine-tolerant rats, hexarelin given with morphine attenuated analgesic tolerance to morphine.

    In plain wordsIn rats given morphine, hexarelin given with morphine reduced the loss of morphine's pain-relieving effect.

    Peptide
    Hexarelin
    Outcome
    DecreaseMorphine antinociceptive tolerance
    Study

    ratn: not reported in source

    Morphine-tolerant rat model
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.2 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    The findings suggest that hexarelin in combination with morphine attenuates analgesic tolerance to morphine.
    2 context sentences
    Summary · context
    A total of 104 Wistar albino male adult rats (weighing approximately 220-240 g) were used in the experiments.
    Summary · context
    To induce morphine tolerance, a three-day cumulative dose regimen was used in the rats.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In rats, hexarelin given together with morphine increased the analgesic effect.

    In plain wordsIn rats, giving hexarelin together with morphine increased pain relief.

    Peptide
    Hexarelin
    Outcome
    IncreaseAnalgesic effect of morphine with hexarelin
    Study

    ratn: not reported in source

    Morphine-tolerant rat model
    Outcome group
    Pain · Nervous system and cognition
    Studied dose
    0.2 mg/kgAs given in this study (rat).

    Source sentences

    Summary
    Furthermore, co-administration of hexarelin and morphine increases the analgesic effect.
    2 context sentences
    Summary · context
    A total of 104 Wistar albino male adult rats (weighing approximately 220-240 g) were used in the experiments.
    Summary · context
    To induce morphine tolerance, a three-day cumulative dose regimen was used in the rats.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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