Study · In vitro (cells) · mouse · 2020
7 resultsZhang W, Wu Y
Neuroreport1 Oct 2020Cited by 7 (Europe PMC)
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Text rights: CC BY-NC-ND. Results still quote short attributed sentences.
7 results from studies that gave the peptide. No result from this study comes from people.
In Neuro2a murine neuronal cells, NDP-MSH promoted neurite outgrowth.
In plain wordsIn lab-grown mouse nerve cells, NDP-MSH promoted the growth of nerve cell extensions.
Mousen: not reported in source
Neuro2a murine neuronal cellsSource sentences
In Neuro2a cells, NDP-MSH promoted neurite outgrowth.
In Neuro2a murine neuronal cells, NDP-MSH greatly enhanced BDNF expression.
In plain wordsIn lab-grown mouse nerve cells, NDP-MSH greatly raised the expression of BDNF.
Mousen: not reported in source
Neuro2a murine neuronal cellsSource sentences
Upon NDP-MSH administration, BDNF expression was greatly enhanced.
In Neuro2a murine neuronal cells, the MC4R antagonist JKC-363 reversed the NDP-MSH-induced BDNF increase.
In plain wordsIn lab-grown mouse nerve cells, a blocker of the MC4R receptor reversed the BDNF rise caused by NDP-MSH.
Mousen: not reported in source
Neuro2a murine neuronal cellsSource sentences
Furthermore, this effect was effectively reversed by the MC4R antagonist, JKC-363.
In Neuro2a murine neuronal cells, NDP-MSH treatment activated the ERK cascade.
In plain wordsIn lab-grown mouse nerve cells, NDP-MSH switched on the ERK signaling cascade.
Mousen: not reported in source
Neuro2a murine neuronal cellsSource sentences
We found that NDP-MSH treatment activated the ERK cascade
In Neuro2a murine neuronal cells, NDP-MSH treatment activated the downstream kinase MSK1.
In plain wordsIn lab-grown mouse nerve cells, NDP-MSH switched on the signaling enzyme MSK1.
Mousen: not reported in source
Neuro2a murine neuronal cellsSource sentences
We found that NDP-MSH treatment activated the ERK cascade and its downstream kinase MSK1 (mitogen- and stress-activated protein kinase-1).
In Neuro2a murine neuronal cells, MSK1 inhibition or a defective MSK1 mutant interrupted CREB phosphorylation and blocked BDNF upregulation.
In plain wordsIn lab-grown mouse nerve cells, blocking MSK1 stopped CREB activation and the BDNF rise seen with NDP-MSH.
Mousen: not reported in source
Neuro2a murine neuronal cellsSource sentences
Antagonism of the MSK1 cascade by a specific inhibitor or overexpression of a defective MSK1 mutant interrupted the phosphorylation of the transcription factor cAMP-response element binding protein (CREB), blocking BDNF upregulation.
In Neuro2a murine neuronal cells, MSK1 activation triggered an epigenetic alteration in histone H3 (Ser10) that facilitated BDNF gene expression.
In plain wordsIn lab-grown mouse nerve cells, MSK1 activation changed histone H3, which helped switch on the BDNF gene.
Mousen: not reported in source
Neuro2a murine neuronal cellsSource sentences
In addition, MSK1 activation triggered an epigenetic alteration in histone H3 (Ser10), facilitating the expression of the BDNF gene.
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Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC
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