Attenuation of Visceral and Somatic Nociception by Ghrelin Mimetics.

N Mohammadi E, Louwies T, Pietra C, Northrup SR, Greenwood-Van Meerveld B

Journal of experimental pharmacology5 Aug 2020Cited by 3 (Europe PMC)

PMID32801950PMCIDPMC7415447DOI10.2147/jep.s249747PepBankPUB-32801950

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In rats with acetic acid-induced visceral hypersensitivity, ipamorelin significantly attenuated colonic hypersensitivity compared with vehicle.
In plain wordsIn rats, ipamorelin reduced gut pain sensitivity compared with vehicle.
Peptide
Ipamorelin
Outcome
DecreaseColonic hypersensitivity (visceromotor response)
Study
ratn: not reported in source
Acetic acid-induced non-inflammatory visceral hypersensitivity
Comparator
Vehicle
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
Compared to vehicle controls, ghrelin mimetics HM01 and ipamorelin significantly attenuated colonic hypersensitivity and somatic allodynia.
2 context sentences(design, population, supporting numbers)
Summary · context
Visceral hypersensitivity was induced by dilute acetic acid (0.6%) infusion in the colon of rats in the absence of colonic epithelial inflammation.
Summary · context
Ghrelin mimetics HM01 and ipamorelin were administered orally or intravenously, respectively.
Report a problemFND-3280195001
02AnimalAnimal study (in vivo)Efficacy outcome
In rats with acetic acid-induced visceral hypersensitivity, ipamorelin significantly attenuated somatic mechanical allodynia compared with vehicle.
In plain wordsIn rats, ipamorelin reduced paw pain sensitivity to touch compared with vehicle.
Peptide
Ipamorelin
Outcome
DecreaseSomatic mechanical allodynia
Study
ratn: not reported in source
Acetic acid-induced non-inflammatory visceral hypersensitivity
Comparator
Vehicle
Outcome group
Pain · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
Compared to vehicle controls, ghrelin mimetics HM01 and ipamorelin significantly attenuated colonic hypersensitivity and somatic allodynia.
2 context sentences(design, population, supporting numbers)
Summary · context
Visceral hypersensitivity was induced by dilute acetic acid (0.6%) infusion in the colon of rats in the absence of colonic epithelial inflammation.
Summary · context
Ghrelin mimetics HM01 and ipamorelin were administered orally or intravenously, respectively.
Report a problemFND-3280195002
03AnimalAnimal study (in vivo)Mechanism
In rats, the ghrelin receptor antagonist H0900 blocked the anti-nociceptive effects of the ghrelin mimetics, including ipamorelin.
In plain wordsIn rats, a drug that blocks the ghrelin receptor stopped the pain-reducing effects of ipamorelin.
Peptide
Ipamorelin
Outcome
Not applicableBlockade of anti-nociceptive effect by ghrelin receptor antagonist
Study
ratn: not reported in source
Acetic acid-induced non-inflammatory visceral hypersensitivity
Comparator
Ghrelin receptor antagonist H0900
Outcome group
Receptor activity and mechanism · Nervous system and cognition
Studied dose
Dose not stated · intravenousAs given in this study (rat).
Source sentences
Summary
The anti-nociceptive effects of the ghrelin mimetics were blocked after administration of the ghrelin receptor antagonist H0900.
2 context sentences(design, population, supporting numbers)
Summary · context
Visceral hypersensitivity was induced by dilute acetic acid (0.6%) infusion in the colon of rats in the absence of colonic epithelial inflammation.
Summary · context
Ghrelin mimetics HM01 and ipamorelin were administered orally or intravenously, respectively.
Report a problemFND-3280195003

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
9 Oct 2026, 18:17 UTC
Study results updated
Version 1
9 Oct 2026, 03:13 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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