Skip to content

Study · Animal study (in vivo) · pig · 2020

2 results

Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.

Sharp TE 3rd, Gong Z, Scarborough A, Goetzman ES, Ali MJ, Spaletra P, Lefer DJ, Muzumdar RH, Goodchild TT

JACC. Basic to translational science17 Jun 2020Cited by 21 (Europe PMC)

PMID32760857 (opens in a new tab)PMCIDPMC7393416 (opens in a new tab)DOI10.1016/j.jacbts.2020.04.015 (opens in a new tab)PepBankPUB-32760857
Read at sourcePubMedAsk about this study
Jump to 2 results

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study2

2 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In a pig model of myocardial ischemia/reperfusion, S14G-humanin at 2 mg/kg reduced infarct size.

    In plain wordsIn pigs with a heart attack model, a humanin analogue reduced the size of the damaged heart area.

    Peptide
    Humanin
    Outcome
    DecreaseInfarct size after 60-min ischemia
    Study

    pign: not reported in source

    Porcine myocardial ischemia/reperfusion model
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    2 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    This study found that the mitochondrial-derived peptide S14G-humanin (HNG) (2 mg/kg), an analogue of humanin, reduced infarct size in a large animal model of MI/R.
    1 context sentence
    Title · context
    Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In a pig model of myocardial ischemia/reperfusion, the infarct-sparing effect of S14G-humanin at the same dose was abolished when ischemic time was increased.

    In plain wordsIn pigs, the humanin analogue no longer reduced heart damage when blood flow was blocked for longer.

    Peptide
    Humanin
    Outcome
    No significant changeInfarct size with longer ischemic time
    Study

    pign: not reported in source

    Porcine myocardial ischemia/reperfusion model
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    2 mg/kgAs given in this study (pig).

    Source sentences

    Summary
    However, when ischemic time was increased, the infarct-sparing effects were abolished with the same dose of HNG.
    1 context sentence
    Title · context
    Efficacy of a Novel Mitochondrial-Derived Peptide in a Porcine Model of Myocardial Ischemia/Reperfusion Injury.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Keywords

PepBank is a research reference. Talk to a doctor before you use any peptide.