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Study · Animal study (in vivo) · mouse · 2020

10 results

Nicotinamide Mononucleotide Supplementation Reverses the Declining Quality of Maternally Aged Oocytes.

Miao Y, Cui Z, Gao Q, Rui R, Xiong B

Cell reports1 Aug 2020Cited by 269 (Europe PMC)

PMID32755581 (opens in a new tab)DOI10.1016/j.celrep.2020.107987 (opens in a new tab)PepBankPUB-32755581
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study10

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In naturally aged mice, NMN improved oocyte quality.

    In plain wordsIn aged mice, NMN improved egg quality.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOocyte quality
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we report that in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously improves the quality of oocytes from naturally aged mice by recovering nicotinamide adenine dinucleotide (NAD+) levels.
  2. 02AnimalAnimal study (in vivo)Mechanism

    In naturally aged mice, NMN restored oocyte NAD+ levels.

    In plain wordsIn aged mice, NMN restored NAD+ levels in eggs.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOocyte NAD+
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Mitochondrial function · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Here, we report that in vivo supplementation of nicotinamide mononucleotide (NMN) efficaciously improves the quality of oocytes from naturally aged mice by recovering nicotinamide adenine dinucleotide (NAD+) levels.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, NMN increased ovulation of aged oocytes.

    In plain wordsIn aged mice, NMN increased egg release.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseOvulation
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation not only increases ovulation of aged oocytes but also enhances their meiotic competency and fertilization ability by maintaining the normal spindle/chromosome structure and the dynamics of the cortical granule component ovastacin.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, NMN enhanced oocyte meiotic competency.

    In plain wordsIn aged mice, NMN improved the ability of eggs to complete meiosis.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMeiotic competency
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation not only increases ovulation of aged oocytes but also enhances their meiotic competency and fertilization ability by maintaining the normal spindle/chromosome structure and the dynamics of the cortical granule component ovastacin.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In aged mice, NMN enhanced oocyte fertilization ability.

    In plain wordsIn aged mice, NMN improved the ability of eggs to be fertilized.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseFertilization ability
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation not only increases ovulation of aged oocytes but also enhances their meiotic competency and fertilization ability by maintaining the normal spindle/chromosome structure and the dynamics of the cortical granule component ovastacin.
  6. 06AnimalAnimal study (in vivo)Mechanism

    In aged mice, NMN maintained normal oocyte spindle/chromosome structure.

    In plain wordsIn aged mice, NMN maintained normal egg spindle and chromosome structure.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableSpindle/chromosome structure
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation not only increases ovulation of aged oocytes but also enhances their meiotic competency and fertilization ability by maintaining the normal spindle/chromosome structure and the dynamics of the cortical granule component ovastacin.
  7. 07AnimalAnimal study (in vivo)Mechanism

    In aged mice, NMN maintained oocyte cortical granule ovastacin dynamics.

    In plain wordsIn aged mice, NMN maintained the dynamics of ovastacin in eggs.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    Not applicableOvastacin dynamics
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    NMN supplementation not only increases ovulation of aged oocytes but also enhances their meiotic competency and fertilization ability by maintaining the normal spindle/chromosome structure and the dynamics of the cortical granule component ovastacin.

Studies that did not test the peptide alone3

In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking NMN (nicotinamide mononucleotide).

  1. 08Computer modelNot a test of NMN (nicotinamide mononucleotide) aloneIn silicoMechanism

    Single-cell transcriptome analysis implicated restored mitochondrial function in NMN benefits in aged mouse oocytes.

    In plain wordsComputer analysis linked NMN benefits in aged mouse eggs to restored mitochondrial function.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    IncreaseMitochondrial function
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Mitochondrial function · Reproductive and sexual health

    Source sentences

    Summary
    Moreover, single-cell transcriptome analysis shows that the beneficial effect of NMN on aged oocytes is mediated by restoration of mitochondrial function, eliminating the accumulated ROS to suppress apoptosis.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  2. 09Computer modelNot a test of NMN (nicotinamide mononucleotide) aloneIn silicoMechanism

    Single-cell transcriptome analysis implicated reduced ROS accumulation in NMN benefits in aged mouse oocytes.

    In plain wordsComputer analysis linked NMN benefits in aged mouse eggs to reduced reactive oxygen species.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseROS accumulation
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Mitochondrial function · Reproductive and sexual health

    Source sentences

    Summary
    Moreover, single-cell transcriptome analysis shows that the beneficial effect of NMN on aged oocytes is mediated by restoration of mitochondrial function, eliminating the accumulated ROS to suppress apoptosis.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

  3. 10Computer modelNot a test of NMN (nicotinamide mononucleotide) aloneIn silicoMechanism

    Single-cell transcriptome analysis implicated apoptosis suppression in NMN benefits in aged mouse oocytes.

    In plain wordsComputer analysis linked NMN benefits in aged mouse eggs to reduced cell death.

    Peptide
    NMN (nicotinamide mononucleotide)
    Outcome
    DecreaseApoptosis
    Study

    mousen: not reported in source

    Naturally aged mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Moreover, single-cell transcriptome analysis shows that the beneficial effect of NMN on aged oocytes is mediated by restoration of mitochondrial function, eliminating the accumulated ROS to suppress apoptosis.

    In this study, NMN (nicotinamide mononucleotide) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking NMN (nicotinamide mononucleotide).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    21 Oct 2026, 15:58 UTC

    Study results updated

  2. Version 1

    21 Oct 2026, 12:50 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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