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Study · Measured the body's own peptide · 2021

3 results

Amniotic fluid peptides predict postnatal kidney survival in developmental kidney disease.

Klein J, Buffin-Meyer B, Boizard F, Moussaoui N, Lescat O, Breuil B, Fedou C, Feuillet G, Casemayou A, Neau E, Hindryckx A, Decatte L and 38 more

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Levtchenko E, Raaijmakers A, Vayssière C, Goua V, Lucas C, Perrotin F, Cloarec S, Benachi A, Manca-Pellissier MC, Delmas HL, Bessenay L, Le Vaillant C, Allain-Launay E, Gondry J, Boudailliez B, Simon E, Prieur F, Lavocat MP, Saliou AH, De Parscau L, Bidat L, Noel C, Floch C, Bourdat-Michel G, Favre R, Weingertner AS, Oury JF, Baudouin V, Bory JP, Pietrement C, Fiorenza M, Massardier J, Kessler S, Lounis N, Auriol FC, Marcorelles P, Collardeau-Frachon S, Zürbig P

Kidney international1 Aug 2020Cited by 21 (Europe PMC)

PMID32750455 (opens in a new tab)DOI10.1016/j.kint.2020.06.043 (opens in a new tab)PepBankPUB-32750455
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

No result from this study comes from a test of the peptide.

Natural levels measured2

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 01HumanEndogenous levelObservational studyOther

    In fetuses with CAKUT, fragments of thymosin-b4 were a main component of a 98-peptide amniotic fluid signature that predicted postnatal kidney outcome.

    In plain wordsIn pregnancies with kidney anomalies, pieces of the body's own thymosin beta‑4 were part of a fluid signature linked to later kidney outcome.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableThymosin-b4 fragments in the amniotic fluid peptide signature for CAKUT
    Study

    n = 140

    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    We identified a signature of 98 endogenous amniotic fluid peptides, mainly composed of fragments from extracellular matrix proteins and from the actin binding protein thymosin-β4.
    1 context sentence
    Summary · context
    To improve prediction, we conducted a prospective multicenter peptidome analysis of amniotic fluid spanning 140 evaluable fetuses with CAKUT.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

  2. 02HumanEndogenous levelObservational studyOther

    In amniotic fluid from fetuses with CAKUT, the change in thymosin-b4 abundance was confirmed with ELISA.

    In plain wordsIn amniotic fluid, a second test confirmed a change in the body's own thymosin beta‑4 levels.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Not applicableAmniotic fluid thymosin-b4 abundance confirmed by ELISA
    Study

    n: not reported in source

    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Change in amniotic fluid thymosin-β4 abundance was confirmed with ELISA.
    1 context sentence
    Summary · context
    To improve prediction, we conducted a prospective multicenter peptidome analysis of amniotic fluid spanning 140 evaluable fetuses with CAKUT.

    This result measures the body's own Thymosin beta-4 (human). Nobody was given the peptide. It is not evidence about taking it.

Studies that did not test the peptide alone1

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

  1. 03AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism

    In zebrafish, knockout of thymosin-b4 altered proximal and distal tubule pronephros growth.

    In plain wordsIn zebrafish, removing thymosin beta‑4 changed the growth of kidney tubules.

    Peptide
    Thymosin beta-4 (human)
    Outcome
    Direction not reportedPronephros tubule growth after thymosin-b4 knockout
    Study

    zebrafishn: not reported in source

    thymosin-b4 knockout zebrafish
    Outcome group
    Kidney function · Kidney and urinary

    Source sentences

    Summary
    Knockout of thymosin-β4 in zebrafish altered proximal and distal tubule pronephros growth suggesting a possible role of thymosin β4 in fetal kidney development.

    In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 01:52 UTC

    Study results updated

  2. Version 1

    12 Oct 2026, 18:17 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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