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Study · Animal study (in vivo) · mouse · 2020

7 results

The Mitochondria-targeted Peptide, Bendavia, Attenuated Ischemia/Reperfusion-induced Stroke Damage.

Imai T, Matsubara H, Nakamura S, Hara H, Shimazawa M

Neuroscience30 Jul 2020Cited by 31 (Europe PMC)

PMID32738431 (opens in a new tab)DOI10.1016/j.neuroscience.2020.07.044 (opens in a new tab)PepBankPUB-32738431
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice after transient middle cerebral artery occlusion, bendavia attenuated sensori-motor dysfunction compared with vehicle.

    In plain wordsIn mice with induced stroke, bendavia reduced movement and sensation problems compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseSensori-motor dysfunction after t-MCAO
    Study

    mousen: not reported in source

    t-MCAO ischemia/reperfusion
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · administered twice, immediately after reperfusion and 4 h laterAs given in this study (mouse).

    Source sentences

    Summary
    Compared to the vehicle group, bendavia administration (administered twice; immediately after reperfusion and 4 h later) attenuated the sensori-motor dysfunction and infarct formation independent of CBF variation.
    1 context sentence
    Summary · context
    The in vivo experiments were conducted in mice, which were subjected to transient middle cerebral occlusion (t-MCAO) to induce brain ischemia/reperfusion damage.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice after transient middle cerebral artery occlusion, bendavia attenuated infarct formation compared with vehicle.

    In plain wordsIn mice with induced stroke, bendavia reduced the size of brain damage compared with vehicle.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseInfarct formation after t-MCAO
    Study

    mousen: not reported in source

    t-MCAO ischemia/reperfusion
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · administered twice, immediately after reperfusion and 4 h laterAs given in this study (mouse).

    Source sentences

    Summary
    Compared to the vehicle group, bendavia administration (administered twice; immediately after reperfusion and 4 h later) attenuated the sensori-motor dysfunction and infarct formation independent of CBF variation.
    1 context sentence
    Summary · context
    The in vivo experiments were conducted in mice, which were subjected to transient middle cerebral occlusion (t-MCAO) to induce brain ischemia/reperfusion damage.
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In mice after transient middle cerebral artery occlusion, the protective effects of bendavia on dysfunction and infarct were independent of cerebral blood flow variation.

    In plain wordsIn mice with induced stroke, bendavia's protective effects did not depend on changes in blood flow to the brain.

    Peptide
    Elamipretide (SS-31)
    Outcome
    No significant changeCerebral blood flow after t-MCAO
    Study

    mousen: not reported in source

    t-MCAO ischemia/reperfusion
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated · administered twice, immediately after reperfusion and 4 h laterAs given in this study (mouse).

    Source sentences

    Summary
    Compared to the vehicle group, bendavia administration (administered twice; immediately after reperfusion and 4 h later) attenuated the sensori-motor dysfunction and infarct formation independent of CBF variation.
    1 context sentence
    Summary · context
    The in vivo experiments were conducted in mice, which were subjected to transient middle cerebral occlusion (t-MCAO) to induce brain ischemia/reperfusion damage.
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In mice after transient middle cerebral artery occlusion, bendavia decreased blood-brain barrier hyper-permeability.

    In plain wordsIn mice with induced stroke, bendavia reduced leakiness of the blood-brain barrier.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseBlood-brain barrier permeability after t-MCAO
    Study

    mousen: not reported in source

    t-MCAO ischemia/reperfusion
    Comparator
    Vehicle
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, bendavia decreased BBB hyper-permeability and microglia/macrophage activation.
    1 context sentence
    Summary · context
    The in vivo experiments were conducted in mice, which were subjected to transient middle cerebral occlusion (t-MCAO) to induce brain ischemia/reperfusion damage.
  5. 05AnimalAnimal study (in vivo)Efficacy outcome

    In mice after transient middle cerebral artery occlusion, bendavia decreased microglia/macrophage activation.

    In plain wordsIn mice with induced stroke, bendavia reduced activation of the brain's immune cells.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseMicroglia/macrophage activation after t-MCAO
    Study

    mousen: not reported in source

    t-MCAO ischemia/reperfusion
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Immune and inflammation
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In addition, bendavia decreased BBB hyper-permeability and microglia/macrophage activation.
    1 context sentence
    Summary · context
    The in vivo experiments were conducted in mice, which were subjected to transient middle cerebral occlusion (t-MCAO) to induce brain ischemia/reperfusion damage.
  6. 06LabIn vitro (cells)Efficacy outcome

    In neurons exposed to oxygen/glucose deprivation and re-oxygenation, bendavia inhibited neuronal cell death.

    In plain wordsIn cells, bendavia reduced nerve cell death caused by oxygen and glucose deprivation.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNeuronal cell death after OGD/R
    Study

    n: not reported in source

    neurons, oxygen/glucose deprivation and re-oxygenation
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both models, bendavia inhibited neuronal cell death induced by OGD/R or H2O2.
    2 context sentences
    Summary · context
    The in vitro experiments were conducted utilizing two models: (1) OGD/re-oxygenation (OGD/R) or (2) hydrogen peroxide (H2O2)-induced neuron damage.
    Summary · context
    The in vivo experiments were conducted in mice, which were subjected to transient middle cerebral occlusion (t-MCAO) to induce brain ischemia/reperfusion damage.
  7. 07LabIn vitro (cells)Efficacy outcome

    In neurons exposed to hydrogen peroxide, bendavia inhibited neuronal cell death.

    In plain wordsIn cells, bendavia reduced nerve cell death caused by hydrogen peroxide.

    Peptide
    Elamipretide (SS-31)
    Outcome
    DecreaseNeuronal cell death after H2O2
    Study

    n: not reported in source

    neurons, H2O2-induced damage
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In both models, bendavia inhibited neuronal cell death induced by OGD/R or H2O2.
    2 context sentences
    Summary · context
    The in vitro experiments were conducted utilizing two models: (1) OGD/re-oxygenation (OGD/R) or (2) hydrogen peroxide (H2O2)-induced neuron damage.
    Summary · context
    The in vivo experiments were conducted in mice, which were subjected to transient middle cerebral occlusion (t-MCAO) to induce brain ischemia/reperfusion damage.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    9 Oct 2026, 18:17 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 02:47 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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