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Study · Animal study (in vivo) · rat · 2020

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Composition of Colon Microbiota in Rats Treated with ACTH(4-7)-PGP Peptide (Semax) under Conditions of Restraint Stress.

Svishcheva MV, Mukhina AY, Medvedeva OA, Shevchenko AV, Bobyntsev II, Kalutskii PV, Andreeva LA, Myasoedov NF

Bulletin of experimental biology and medicine1 Jul 2020Cited by 3 (Europe PMC)

PMID32737723 (opens in a new tab)DOI10.1007/s10517-020-04886-7 (opens in a new tab)PepBankPUB-32737723
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study1

1 result from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In Wistar rats under chronic restraint stress, Semax at 50 and 150 μg/kg prevented the stress-induced changes in colon microbiota composition.

    In plain wordsIn rats under stress, Semax at two doses stopped stress from changing the make-up of gut bacteria.

    Peptide
    Semax
    Outcome
    MixedStress-induced changes in colon microbiota composition
    Study

    ratn: not reported in source

    Wistar male rats, chronic restraint stress
    Outcome group
    Gut microbiota · Gastrointestinal
    Studied dose
    50 and 150 μg/kg · intraperitonealAs given in this study (rat).

    Source sentences

    Summary
    Semax in doses of 50 and 150 μg/kg prevented the stress-induced changes in the composition of colon microbiota.
    2 context sentences
    Summary · context
    We studied the effect of Semax on the state of intestinal microbiota in rats subjected to restraint stress.
    Summary · context
    Semax was injected to Wistar male rats intraperitoneally in doses of 5, 50, 150, 450 μg/kg 12-15 min before modelling chronic restraint stress.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    27 Oct 2026, 16:35 UTC

    Study data updated · source update from Europe PMC

  2. Version 2

    9 Oct 2026, 19:08 UTC

    Study results updated

  3. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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