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Study · Case report or series · n = 2 · 2020

3 results

Severe Methemoglobinemia and Death From Intentional Sodium Nitrite Ingestions.

Mudan A, Repplinger D, Lebin J, Lewis J, Vohra R, Smollin C

The Journal of emergency medicine23 Jul 2020Cited by 40 (Europe PMC)

PMID32713620 (opens in a new tab)DOI10.1016/j.jemermed.2020.06.031 (opens in a new tab)PepBankPUB-32713620
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study3

3 results from studies that gave the peptide. 3 results from people.

  1. 01HumanCase report or seriesEfficacy outcome

    Two patients with severe sodium-nitrite-induced methemoglobinemia survived after receiving methylene blue early in their clinical course.

    In plain wordsTwo patients with severe sodium-nitrite-induced methemoglobinemia survived after early methylene blue treatment.

    Peptide
    Methylene blue
    Outcome
    Not applicableSurvival
    Study

    n = 2

    Outcome group
    Mortality · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The 2 patients who survived received methylene blue early in their clinical course.
    1 context sentence
    Summary · context
    We report five cases of severe methemoglobinemia secondary to large sodium nitrite ingestion that were reported to and managed by the California Poison Control System in 2019, resulting in three fatalities.
  2. 02HumanCase report or seriesEfficacy outcome

    In the methylene blue-treated survivors of sodium nitrite ingestion, all symptoms resolved within 24 h.

    In plain wordsAll symptoms resolved within 24 h in the methylene blue-treated survivors of sodium nitrite ingestion.

    Peptide
    Methylene blue
    Outcome
    DecreaseSymptom resolution
    Study

    n = 2

    Outcome group
    Overall treatment effect · Whole body
    Studied dose
    Dose not stated

    Measurements

    Time to symptom resolution
    ≤ 24 h
    survivors who received MB

    Source sentences

    Summary
    In the patients who survived, all symptoms resolved within 24 h.
    2 context sentences
    Summary · context
    The 2 patients who survived received methylene blue early in their clinical course.
    Summary · context
    We report five cases of severe methemoglobinemia secondary to large sodium nitrite ingestion that were reported to and managed by the California Poison Control System in 2019, resulting in three fatalities.
  3. 03HumanCase report or seriesOther

    One sodium nitrite ingestion patient required higher methylene blue doses than other nitrite-associated methemoglobinemia cases.

    In plain wordsOne sodium nitrite ingestion patient required higher methylene blue doses than other nitrite-associated methemoglobinemia cases.

    Peptide
    Methylene blue
    Outcome
    IncreaseHigher dose requirement
    Study

    n = 1

    Comparator
    Other cases of nitrite-associated methemoglobinemia
    Outcome group
    Patterns of use · Pharmacology
    Studied dose
    Dose not stated

    Source sentences

    Summary
    One patient required higher doses of methylene blue compared with other cases of nitrite-associated methemoglobinemia.
    1 context sentence
    Summary · context
    We report five cases of severe methemoglobinemia secondary to large sodium nitrite ingestion that were reported to and managed by the California Poison Control System in 2019, resulting in three fatalities.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    14 Oct 2026, 05:02 UTC

    Study results updated

  2. Version 1

    14 Oct 2026, 01:46 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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