The efficacy of gonadotropin-releasing hormone (GNRH) agonist before frozen embryo transfer in improving pregnancy outcome and decreasing miscarriage rate in hyperandrogenic polycystic ovary syndrome women: a randomized clinical trial.

Aghahoseini M, Alyasin A, Rashidi S, Samaei-Nouroozi A, Saeidi H, Shabani-Nashtaei M

Minerva ginecologica17 Jul 2020Cited by 12 (Europe PMC)

PMID32677772DOI10.23736/s0026-4784.20.04467-6PepBankPUB-32677772

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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

4 results from studies that gave the peptide. 4 results from people.

01HumanRandomized controlled trialEfficacy outcome
In infertile women with PCOS, diphereline did not significantly change chemical pregnancy rates versus control.
In plain wordsIn infertile women with PCOS, chemical pregnancy rates did not differ significantly between diphereline and control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeChemical pregnancy
Study
n = 178
Comparator
standard endometrial preparation without diphereline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
two doses, 8 weeks before starting the endometrial preparationAs given in this study (human).
Measurements
Chemical pregnancy
47.7%
diphereline
Chemical pregnancy
35.6%
control
Source sentences
Summary
Chemical pregnancy in intervention group was 47.7% compared to 35.6% in the control group, revealing no significant difference between two groups.
4 context sentences(design, population, supporting numbers)
Summary · context
This study was conducted to investigate the efficacy of GnRH agonist before frozen-thawed embryo transfer in improving pregnancy outcome in infertile women with PCOS.
Summary · context
This single-blind, randomized controlled trial was performed at Dr Shariati hospital and Omid Fertility Clinic in Tehran, Iran.
Summary · context
All women received the standard treatment for the preparation of the endometrial using estradiol valerate at dose of 6-8 mg/day.
Summary · context
The intervention group also received diphereline, as GnRH agonist, at two doses, 8 weeks before starting the endometrial preparation.
Report a problemFND-3267777201
02HumanRandomized controlled trialEfficacy outcome
In infertile women with PCOS, diphereline did not significantly change clinical pregnancy rates versus control.
In plain wordsIn infertile women with PCOS, clinical pregnancy rates did not differ significantly between diphereline and control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeClinical pregnancy
Study
n = 178
Comparator
standard endometrial preparation without diphereline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
two doses, 8 weeks before starting the endometrial preparationAs given in this study (human).
Measurements
Clinical pregnancy
43.2%
intervention
Clinical pregnancy
27.3%
control
Source sentences
Summary
No statistically significant difference was observed between two groups concerning clinical pregnancy rate (43.2% vs. 27.3%).
4 context sentences(design, population, supporting numbers)
Summary · context
This study was conducted to investigate the efficacy of GnRH agonist before frozen-thawed embryo transfer in improving pregnancy outcome in infertile women with PCOS.
Summary · context
This single-blind, randomized controlled trial was performed at Dr Shariati hospital and Omid Fertility Clinic in Tehran, Iran.
Summary · context
All women received the standard treatment for the preparation of the endometrial using estradiol valerate at dose of 6-8 mg/day.
Summary · context
The intervention group also received diphereline, as GnRH agonist, at two doses, 8 weeks before starting the endometrial preparation.
Report a problemFND-3267777202
03HumanRandomized controlled trialEfficacy outcome
In infertile women with PCOS, diphereline increased ongoing pregnancy rates versus control.
In plain wordsIn infertile women with PCOS, ongoing pregnancy rates were higher with diphereline than with control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseOngoing pregnancy
Study
n = 178
Comparator
standard endometrial preparation without diphereline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
two doses, 8 weeks before starting the endometrial preparationAs given in this study (human).
Measurements
Ongoing pregnancy
42%
intervention
Ongoing pregnancy
18%
control
Source sentences
Summary
However, rate of ongoing pregnancy was 42.0% in intervention group but 18.0% in the control group, suggesting a significant difference (P=0.001).
4 context sentences(design, population, supporting numbers)
Summary · context
This study was conducted to investigate the efficacy of GnRH agonist before frozen-thawed embryo transfer in improving pregnancy outcome in infertile women with PCOS.
Summary · context
This single-blind, randomized controlled trial was performed at Dr Shariati hospital and Omid Fertility Clinic in Tehran, Iran.
Summary · context
All women received the standard treatment for the preparation of the endometrial using estradiol valerate at dose of 6-8 mg/day.
Summary · context
The intervention group also received diphereline, as GnRH agonist, at two doses, 8 weeks before starting the endometrial preparation.
Report a problemFND-3267777203
04HumanRandomized controlled trialEfficacy outcome
In infertile women with PCOS, diphereline reduced miscarriage rates versus control.
In plain wordsIn infertile women with PCOS, miscarriage rates were lower with diphereline than with control.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseMiscarriage
Study
n: not reported in source
Comparator
standard endometrial preparation without diphereline
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Studied dose
two doses, 8 weeks before starting the endometrial preparationAs given in this study (human).
Measurements
Miscarriage
2.6%
intervention
Miscarriage
33.3%
control
Source sentences
Summary
The rate of miscarriage in the intervention group was 2.6% and in the control group was 33.3%, which was significantly lower (P=0.001).
4 context sentences(design, population, supporting numbers)
Summary · context
This study was conducted to investigate the efficacy of GnRH agonist before frozen-thawed embryo transfer in improving pregnancy outcome in infertile women with PCOS.
Summary · context
This single-blind, randomized controlled trial was performed at Dr Shariati hospital and Omid Fertility Clinic in Tehran, Iran.
Summary · context
All women received the standard treatment for the preparation of the endometrial using estradiol valerate at dose of 6-8 mg/day.
Summary · context
The intervention group also received diphereline, as GnRH agonist, at two doses, 8 weeks before starting the endometrial preparation.
Report a problemFND-3267777204

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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