Tβ4 suppresses lincRNA-p21-mediated hepatic apoptosis and fibrosis by inhibiting PI3K-AKT-NF-κB pathway.

Yang L, Fu WL, Zhu Y, Wang XG

Gene7 Jul 2020Cited by 17 (Europe PMC)

PMID32649978DOI10.1016/j.gene.2020.144946PepBankPUB-32649978

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study14

12 results from studies that gave the peptide. No result from this study comes from people.

01AnimalAnimal study (in vivo)Efficacy outcome
In a lincRNA-p21 overexpression model, Tβ4 blocked the hepatocyte apoptosis that lincRNA-p21 promoted.
In plain wordsIn mice, Tβ4 blocked the liver cell death caused by lincRNA-p21 overexpression.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHepatocyte apoptosis induced by lincRNA-p21
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Results showed that lincRNA-p21 overexpression promoted hepatocytes apoptosis, which was blocked by Tβ4.
1 context sentence(design, population, supporting numbers)
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997801
02AnimalAnimal study (in vivo)Mechanism
Tβ4 reversed the increase in cleaved caspase-3 that lincRNA-p21 induced.
In plain wordsIn mice, Tβ4 reversed the rise in a cell death marker, cleaved caspase-3, caused by lincRNA-p21.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCleaved caspase-3 level
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Besides, Tβ4 reversed the levels of cleaved caspase-3 and caspase-9 induced by lincRNA-p21.
1 context sentence(design, population, supporting numbers)
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997802
03AnimalAnimal study (in vivo)Mechanism
Tβ4 reversed the increase in cleaved caspase-9 that lincRNA-p21 induced.
In plain wordsIn mice, Tβ4 reversed the rise in a cell death marker, cleaved caspase-9, caused by lincRNA-p21.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseCleaved caspase-9 level
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
Besides, Tβ4 reversed the levels of cleaved caspase-3 and caspase-9 induced by lincRNA-p21.
1 context sentence(design, population, supporting numbers)
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997803
04AnimalAnimal study (in vivo)Efficacy outcome
Tβ4 reversed the pathological hepatic injury caused by lincRNA-p21 overexpression.
In plain wordsIn mice, Tβ4 reversed the liver tissue damage caused by lincRNA-p21 overexpression.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHepatic pathological injury
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
LincRNA-p21 overexpression also caused the pathological injury and fibrosis in hepatic tissues and increased the levels of fibrosis-related proteins (Collagen I, α-SMA and TIMP-1), and induced hydroxyproline and ALT production.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of overexpression of lincRNA-p21 on hepatic injury and fibrosis.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997804
05AnimalAnimal study (in vivo)Efficacy outcome
Tβ4 reversed the hepatic fibrosis caused by lincRNA-p21 overexpression.
In plain wordsIn mice, Tβ4 reversed the liver scarring caused by lincRNA-p21 overexpression.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHepatic fibrosis
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
LincRNA-p21 overexpression also caused the pathological injury and fibrosis in hepatic tissues and increased the levels of fibrosis-related proteins (Collagen I, α-SMA and TIMP-1), and induced hydroxyproline and ALT production.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of overexpression of lincRNA-p21 on hepatic injury and fibrosis.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997805
06AnimalAnimal study (in vivo)Mechanism
Tβ4 reversed the lincRNA-p21-induced rise in the fibrosis-related proteins Collagen I, α-SMA and TIMP-1.
In plain wordsIn mice, Tβ4 reversed the rise in liver scarring proteins caused by lincRNA-p21 overexpression.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseFibrosis-related proteins (Collagen I, α-SMA, TIMP-1)
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
LincRNA-p21 overexpression also caused the pathological injury and fibrosis in hepatic tissues and increased the levels of fibrosis-related proteins (Collagen I, α-SMA and TIMP-1), and induced hydroxyproline and ALT production.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of overexpression of lincRNA-p21 on hepatic injury and fibrosis.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997806
07AnimalAnimal study (in vivo)Mechanism
Tβ4 reversed the lincRNA-p21-induced rise in hydroxyproline.
In plain wordsIn mice, Tβ4 reversed the rise in hydroxyproline, a scarring marker, caused by lincRNA-p21 overexpression.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHydroxyproline production
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
LincRNA-p21 overexpression also caused the pathological injury and fibrosis in hepatic tissues and increased the levels of fibrosis-related proteins (Collagen I, α-SMA and TIMP-1), and induced hydroxyproline and ALT production.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of overexpression of lincRNA-p21 on hepatic injury and fibrosis.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997807
08AnimalAnimal study (in vivo)Efficacy outcome
Tβ4 reversed the lincRNA-p21-induced rise in ALT.
In plain wordsIn mice, Tβ4 reversed the rise in the liver enzyme ALT caused by lincRNA-p21 overexpression.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseALT production
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
LincRNA-p21 overexpression also caused the pathological injury and fibrosis in hepatic tissues and increased the levels of fibrosis-related proteins (Collagen I, α-SMA and TIMP-1), and induced hydroxyproline and ALT production.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of overexpression of lincRNA-p21 on hepatic injury and fibrosis.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997808
09AnimalAnimal study (in vivo)Mechanism
Tβ4 administration reversed the activation of the PI3K-AKT-NF-κB pathway by lincRNA-p21.
In plain wordsIn mice, Tβ4 reversed the switching on of the PI3K-AKT-NF-κB pathway caused by lincRNA-p21.
Peptide
Thymosin beta-4 (human)
Outcome
DecreasePI3K-AKT-NF-κB pathway activation
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Receptor activity and mechanism · Liver
Studied dose
Dose not stated
Source sentences
Summary
Furthermore, the PI3K-AKT-NF-κB pathway was activated by lincRNA-p21, which was then reversed by the Tβ4 administration.
1 context sentence(design, population, supporting numbers)
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997812
10LabIn vitro (cells)Efficacy outcome
Tβ4 reversed the lincRNA-p21-induced increase in proliferation of hepatic stellate cells.
In plain wordsIn cells, Tβ4 reversed the faster growth of liver stellate cells caused by lincRNA-p21.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseHepatic stellate cell proliferation
Study
n: not reported in source
Hepatic stellate cells with lincRNA-p21 overexpression
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
In vitro experiments, after lincRNA-p21 was overexpressed in hepatic stellate cells (HSCs), the proliferation ability and the levels of HSCs markers α-SMA and Desmin were increased.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of lincRNA-p21 on HSCs.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997809
11LabIn vitro (cells)Mechanism
Tβ4 reversed the lincRNA-p21-induced increase in the stellate cell marker α-SMA.
In plain wordsIn cells, Tβ4 reversed the rise in the stellate cell marker α-SMA caused by lincRNA-p21.
Peptide
Thymosin beta-4 (human)
Outcome
Decreaseα-SMA level in hepatic stellate cells
Study
n: not reported in source
Hepatic stellate cells with lincRNA-p21 overexpression
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
In vitro experiments, after lincRNA-p21 was overexpressed in hepatic stellate cells (HSCs), the proliferation ability and the levels of HSCs markers α-SMA and Desmin were increased.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of lincRNA-p21 on HSCs.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997810
12LabIn vitro (cells)Mechanism
Tβ4 reversed the lincRNA-p21-induced increase in the stellate cell marker Desmin.
In plain wordsIn cells, Tβ4 reversed the rise in the stellate cell marker Desmin caused by lincRNA-p21.
Peptide
Thymosin beta-4 (human)
Outcome
DecreaseDesmin level in hepatic stellate cells
Study
n: not reported in source
Hepatic stellate cells with lincRNA-p21 overexpression
Comparator
lincRNA-p21 overexpression without Tβ4
Outcome group
Liver fat and liver function · Liver
Studied dose
Dose not stated
Source sentences
Summary
In vitro experiments, after lincRNA-p21 was overexpressed in hepatic stellate cells (HSCs), the proliferation ability and the levels of HSCs markers α-SMA and Desmin were increased.
2 context sentences(design, population, supporting numbers)
Summary · context
However, Tβ4 reversed the effects of lincRNA-p21 on HSCs.
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
Report a problemFND-3264997811

Studies that did not test the peptide alone2

In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Thymosin beta-4 (human).

13AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Mechanism
After treatment with the PI3K-AKT activator IGF-1, Tβ4 no longer inhibited the PI3K-AKT-NF-κB pathway.
In plain wordsIn mice given IGF-1, Tβ4 no longer blocked the PI3K-AKT-NF-κB pathway.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeTβ4 inhibition of the pathway with IGF-1
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
Tβ4 without IGF-1
Outcome group
Receptor activity and mechanism · Liver
Source sentences
Summary
After the mice treated by insulin-like growth factor-1 (IGF-1) (the activator of PI3K-AKT), the inhibitory effect of Tβ4 on activated the PI3K-AKT-NF-κB pathway was abrogated.
1 context sentence(design, population, supporting numbers)
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3264997813
14AnimalNot a test of Thymosin beta-4 (human) aloneAnimal study (in vivo)Efficacy outcome
IGF-1 abolished the protective effects of Tβ4 on hepatic apoptosis and fibrosis induced by lincRNA-p21.
In plain wordsIn mice given IGF-1, Tβ4 no longer protected the liver against cell death and scarring.
Peptide
Thymosin beta-4 (human)
Outcome
No significant changeTβ4 protection against apoptosis and fibrosis with IGF-1
Study
mousen: not reported in source
lincRNA-p21 overexpression liver injury
Comparator
Tβ4 without IGF-1
Outcome group
Liver fat and liver function · Liver
Source sentences
Summary
Besides, IGF-1 abolished the protective effects of Tβ4 on hepatic apoptosis and fibrosis induced by lincRNA-p21.
1 context sentence(design, population, supporting numbers)
Summary · context
In the study, the effects of Thymosin β4 (Tβ4) on Long intergenic noncoding RNA-p21 (lincRNA-p21)-mediated liver injury were investigated.
In this study, Thymosin beta-4 (human) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Thymosin beta-4 (human).
Report a problemFND-3264997814

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 01:52 UTC
Study results updated
Version 1
12 Oct 2026, 18:17 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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