Corifollitropin alfa for poor responders patients, a prospective randomized study.

Fusi FM, Zanga L, Arnoldi M, Melis S, Cappato M, Candeloro I, Di Pasqua A

Reproductive biology and endocrinology : RB&E9 Jul 2020Cited by 10 (Europe PMC)

PMID32646462PMCIDPMC7346462DOI10.1186/s12958-020-00628-6PepBankPUB-32646462

Summary

BackgroundPoor ovarian response remains one of the biggest challenges for reproductive endocrinologists. The introduction of corifollitropin alpha (CFA) offered an alternative option to other gonadotropins for its longer half-life, its more rapid achievement of the threshold and higher FSH levels. We compared two different protocols with CFA, a long agonist and a short antagonist, and a no-CFA protocol.MethodsPatients enrolled fulfilled at least two of the followings: AFC 40 years. Ovarian stimulation with an antagonist protocol was performed either with 300 UI rFSH and 150 UI rLH or 300UI HMG. In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day. In the short antagonist group CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day. The primary objective was the effect on the number of oocytes and MII oocytes. Secondary objective were pregnancy rates, ongoing pregnancies and ongoing pregnancies per intention to treat.ResultsThe use of CFA resulted in a shorter lenght of stimulation and a lower number of suspended treatments. Both the CFA protocols were significantly different from the no-CFA group in the number of retrieved oocytes (p < 0,05), with a non-significant difference in favour of the long agonist protocol. Both CFA groups yielded higher pregnancy rates, especially the long protocol, due to the higher number of oocytes retrieved (p < 0,05), as implantation rates did not differ. The cumulative pregnancy rate was also different, due to the higher number of cryopreserved blastocysts (p < 0,02).ConclusionsThe long agonist protocol with the addition of rFSH and rLH showed the best results in all the parameters. A short antagonist protocol with CFA was less effective, but not significantly, although provided better results compared to the no-CFA group. We suggest that a long agonist protocol with CFA and recombinant gonadotropins might be a valuable option for poor responders.Trial registrationThe study was approved by the local Ethics Committee (EudraCT2015-002817-31).

CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study7

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone7

In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Triptorelin (Trelstar, Decapeptyl).

01HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In poor ovarian responders, the triptorelin-containing long CFA regimen yielded more retrieved oocytes than the no-CFA protocol.
In plain wordsIn poor ovarian responders, the triptorelin-containing long CFA regimen yielded more eggs than the no-CFA protocol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreaseRetrieved oocytes versus no-CFA protocol
Study
n: not reported in source
Comparator
no-CFA protocol
Analysis
Primary
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Both the CFA protocols were significantly different from the no-CFA group in the number of retrieved oocytes (p < 0,05), with a non-significant difference in favour of the long agonist protocol.
Summary
Both CFA groups yielded higher pregnancy rates, especially the long protocol, due to the higher number of oocytes retrieved (p < 0,05), as implantation rates did not differ.
2 context sentences(design, population, supporting numbers)
Summary · context
Patients enrolled fulfilled at least two of the followings: AFC 40 years.
Summary · context
In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3264646201
02HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In poor ovarian responders, retrieved oocyte counts did not differ significantly between the triptorelin-containing long CFA regimen and short CFA protocol.
In plain wordsIn poor ovarian responders, egg counts did not differ significantly between the triptorelin-containing long CFA regimen and short CFA protocol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeRetrieved oocytes versus short CFA protocol
Study
n: not reported in source
Comparator
short antagonist CFA protocol
Analysis
Primary
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Both the CFA protocols were significantly different from the no-CFA group in the number of retrieved oocytes (p < 0,05), with a non-significant difference in favour of the long agonist protocol.
2 context sentences(design, population, supporting numbers)
Summary · context
Patients enrolled fulfilled at least two of the followings: AFC 40 years.
Summary · context
In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3264646202
03HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In poor ovarian responders, the triptorelin-containing long CFA regimen yielded higher pregnancy rates than the no-CFA protocol.
In plain wordsIn poor ovarian responders, pregnancy rates were higher with the triptorelin-containing long CFA regimen than with the no-CFA protocol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
IncreasePregnancy rate
Study
n: not reported in source
Comparator
no-CFA protocol
Analysis
Secondary
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Both CFA groups yielded higher pregnancy rates, especially the long protocol, due to the higher number of oocytes retrieved (p < 0,05), as implantation rates did not differ.
2 context sentences(design, population, supporting numbers)
Summary · context
Patients enrolled fulfilled at least two of the followings: AFC 40 years.
Summary · context
In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3264646203
04HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In poor ovarian responders, CFA protocols, including the triptorelin-containing long regimen, shortened stimulation compared with the no-CFA protocol.
In plain wordsIn poor ovarian responders, CFA protocols, including the triptorelin-containing regimen, shortened stimulation compared with the no-CFA protocol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseStimulation duration
Study
n: not reported in source
Comparator
no-CFA protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The use of CFA resulted in a shorter lenght of stimulation and a lower number of suspended treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day.
Summary · context
We compared two different protocols with CFA, a long agonist and a short antagonist, and a no-CFA protocol.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3264646204
05HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In poor ovarian responders, CFA protocols, including the triptorelin-containing long regimen, had fewer suspended treatments than the no-CFA protocol.
In plain wordsIn poor ovarian responders, CFA protocols, including the triptorelin-containing regimen, had fewer suspended treatments than the no-CFA protocol.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
DecreaseSuspended treatments
Study
n: not reported in source
Comparator
no-CFA protocol
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The use of CFA resulted in a shorter lenght of stimulation and a lower number of suspended treatments.
2 context sentences(design, population, supporting numbers)
Summary · context
In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day.
Summary · context
We compared two different protocols with CFA, a long agonist and a short antagonist, and a no-CFA protocol.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3264646205
06HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In poor ovarian responders, implantation rates did not differ among the compared protocols, including the triptorelin-containing long CFA regimen.
In plain wordsIn poor ovarian responders, implantation rates did not differ among protocols, including the triptorelin-containing long CFA regimen.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
No significant changeImplantation rate
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
Both CFA groups yielded higher pregnancy rates, especially the long protocol, due to the higher number of oocytes retrieved (p < 0,05), as implantation rates did not differ.
2 context sentences(design, population, supporting numbers)
Summary · context
In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day.
Summary · context
We compared two different protocols with CFA, a long agonist and a short antagonist, and a no-CFA protocol.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3264646206
07HumanNot a test of Triptorelin (Trelstar, Decapeptyl) aloneRandomized controlled trialEfficacy outcome
In poor ovarian responders, cumulative pregnancy rates differed among the studied stimulation protocols, including the triptorelin-containing long CFA regimen.
In plain wordsIn poor ovarian responders, cumulative pregnancy rates differed among stimulation protocols, including the triptorelin-containing long CFA regimen.
Peptide
Triptorelin (Trelstar, Decapeptyl)
Outcome
Direction not reportedCumulative pregnancy rate
Study
n: not reported in source
Outcome group
Sex hormones and fertility · Reproductive and sexual health
Source sentences
Summary
The cumulative pregnancy rate was also different, due to the higher number of cryopreserved blastocysts (p < 0,02).
2 context sentences(design, population, supporting numbers)
Summary · context
In the long agonist group, after pituitary suppression with triptorelin, CFA was given the 1-2th day of cycle and 300 UI rFSH and 150 UI rLH the 5th day.
Summary · context
We compared two different protocols with CFA, a long agonist and a short antagonist, and a no-CFA protocol.
In this study, Triptorelin (Trelstar, Decapeptyl) was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Triptorelin (Trelstar, Decapeptyl).
Show in the study text Report a problemFND-3264646207

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Registered trials1

Trials this study reports on, or that list this study as a reference. Registry data from ClinicalTrials.gov.

1 trial · 1 completed · source ClinicalTrials.gov (opens in a new tab)

CompletedPhase 3NCT06134479

Comparison of Sequential CFA vs CFA +rFSH for Elective Fertility Preservation.

Fundación Santiago Dexeus Fontn = 19418 Dec 2023 to 9 Sept 2025

Fertility

Trial page ClinicalTrials.govUpdated 23 Jun 2026

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
22 Oct 2026, 02:26 UTC
Study results updated
Version 1
21 Oct 2026, 18:59 UTC
First added · source update from Europe PMC

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