Cytoprotective role of humanin in lens epithelial cell oxidative stress‑induced injury.

Yang H, Cui Y, Tang Y, Tang X, Yu X, Zhou J, Yin Q, Shentu X

Molecular medicine reports2 Jun 2020Cited by 19 (Europe PMC)

PMID32627019PMCIDPMC7339735DOI10.3892/mmr.2020.11202PepBankPUB-32627019

Read at source PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study6

3 results from studies that gave the peptide. No result from this study comes from people.

01LabIn vitro (cells)Efficacy outcome
In human lens epithelial cells under oxidative stress, exogenous humanin reduced intracellular reactive oxygen species content.
In plain wordsIn lens cells under oxidative stress, added humanin lowered reactive oxygen species inside the cells.
Peptide
Humanin
Outcome
DecreaseIntracellular ROS content
Study
humann: not reported in source
Human lens epithelial cells under oxidative stress
Outcome group
Oxidative stress · Eye
Studied dose
Dose not stated
Source sentences
Summary
exogenous HN reduced intracellular ROS content
1 context sentence(design, population, supporting numbers)
Summary · context
Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane potential and mitochondrial DNA copy number, cell viability, LDH activity and apoptosis of HLECs under oxidative stress were detected, and apoptosis and autophagy were detected via transmissi…
Report a problemFND-3262701902
02LabIn vitro (cells)Efficacy outcome
In human lens epithelial cells under oxidative stress, exogenous humanin reduced mitochondrial damage.
In plain wordsIn lens cells under oxidative stress, added humanin reduced damage to mitochondria.
Peptide
Humanin
Outcome
DecreaseMitochondrial damage
Study
humann: not reported in source
Human lens epithelial cells under oxidative stress
Outcome group
Mitochondrial function · Eye
Studied dose
Dose not stated
Source sentences
Summary
exogenous HN reduced intracellular ROS content and mitochondrial damage
1 context sentence(design, population, supporting numbers)
Summary · context
Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane potential and mitochondrial DNA copy number, cell viability, LDH activity and apoptosis of HLECs under oxidative stress were detected, and apoptosis and autophagy were detected via transmissi…
Report a problemFND-3262701903
03LabIn vitro (cells)Efficacy outcome
In human lens epithelial cells under oxidative stress, exogenous humanin enhanced mitochondrial biosynthesis.
In plain wordsIn lens cells under oxidative stress, added humanin increased the making of new mitochondria.
Peptide
Humanin
Outcome
IncreaseMitochondrial biosynthesis
Study
humann: not reported in source
Human lens epithelial cells under oxidative stress
Outcome group
Mitochondrial function · Eye
Studied dose
Dose not stated
Source sentences
Summary
exogenous HN reduced intracellular ROS content and mitochondrial damage, and enhanced mitochondrial biosynthesis
1 context sentence(design, population, supporting numbers)
Summary · context
Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane potential and mitochondrial DNA copy number, cell viability, LDH activity and apoptosis of HLECs under oxidative stress were detected, and apoptosis and autophagy were detected via transmissi…
Report a problemFND-3262701904

Natural levels measured1

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

04LabEndogenous levelIn vitro (cells)Mechanism
In human lens epithelial cells, expression of the body's own humanin was significantly upregulated under oxidative stress conditions.
In plain wordsIn lens cells under oxidative stress, the cells' own humanin levels went up.
Peptide
Humanin
Outcome
IncreaseHN expression under oxidative stress
Study
humann: not reported in source
Human lens epithelial cells under oxidative stress
Outcome group
Mitochondrial function · Eye
Source sentences
Summary
HN expression was significantly upregulated under oxidative stress conditions
1 context sentence(design, population, supporting numbers)
Summary · context
Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane potential and mitochondrial DNA copy number, cell viability, LDH activity and apoptosis of HLECs under oxidative stress were detected, and apoptosis and autophagy were detected via transmissi…
This result measures the body's own Humanin. Nobody was given the peptide. It is not evidence about taking it.
Report a problemFND-3262701901

Studies that did not test the peptide alone2

In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking Humanin.

05LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In human lens epithelial cells, the protection seen with exogenous humanin was lost in an endogenous humanin knockdown cell model.
In plain wordsIn lens cells where the cells' own humanin was knocked down, the protection seen with added humanin was lost.
Peptide
Humanin
Outcome
No significant changeProtection after endogenous HN knockdown
Study
humann: not reported in source
Human lens epithelial cells under oxidative stress
Outcome group
Mitochondrial function · Eye
Source sentences
Summary
however, this protection was lost in an endogenous HN knockdown cell model
1 context sentence(design, population, supporting numbers)
Summary · context
Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane potential and mitochondrial DNA copy number, cell viability, LDH activity and apoptosis of HLECs under oxidative stress were detected, and apoptosis and autophagy were detected via transmissi…
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3262701905
06LabNot a test of Humanin aloneIn vitro (cells)Mechanism
In human lens epithelial cells under oxidative stress, humanin increased mitochondrial autophagy, which was involved in reducing ROS production.
In plain wordsIn lens cells under oxidative stress, humanin increased the clearing of mitochondria, linked to lower reactive oxygen species production.
Peptide
Humanin
Outcome
IncreaseMitochondrial autophagy
Study
humann: not reported in source
Human lens epithelial cells under oxidative stress
Outcome group
Mitochondrial function · Eye
Source sentences
Summary
HN increased mitochondrial autophagy, which was involved in reducing ROS production
1 context sentence(design, population, supporting numbers)
Summary · context
Following HN knockdown or overexpression, the level of reactive oxygen species (ROS), mitochondrial membrane potential and mitochondrial DNA copy number, cell viability, LDH activity and apoptosis of HLECs under oxidative stress were detected, and apoptosis and autophagy were detected via transmissi…
In this study, Humanin was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking Humanin.
Report a problemFND-3262701906

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
13 Oct 2026, 21:44 UTC
Study results updated
Version 1
13 Oct 2026, 16:31 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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