The Efficacy of a Dietary Supplement with Carnosine and Hibiscus Sabdariffa L. (AqualiefTM) in Patients with Xerostomia: a Randomized, Placebo-Controlled, Double-Blind Trial.

Levrini L, Azzi L, Bossi S

La Clinica terapeutica1 Jul 2020Cited by 6 (Europe PMC)

PMID32614361DOI10.7417/ct.2020.2231PepBankPUB-32614361

Publisher page PubMedAsk about this study

Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study4

No result from this study comes from a test of the peptide.

Studies that did not test the peptide alone4

In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. These results are not evidence about taking L-carnosine.

01HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In patients with xerostomia, Aqualief increased saliva pH from 6.2 to 6.4 after 6 days.
In plain wordsIn patients with dry mouth, Aqualief increased saliva pH compared with baseline.
Peptide
L-carnosine
Outcome
IncreaseUnstimulated saliva pH
Study
n: not reported in source
Comparator
Baseline
Outcome group
Gastrointestinal function · Gastrointestinal
Measurements
saliva pH
6.2 pH
Aqualief group, day 0 (SD 0.5)
saliva pH
6.4 pH
Aqualief group, after 6 days (SD 0.6)
saliva pH
6.2 pH
placebo group, day 0 (SD 0.5)
saliva pH
6.3 pH
placebo group, after 6 days (SD 0.5)
Source sentences
Summary
Treatment with AqualiefTM for 6 days induced a significant increase in saliva pH from 6.2 ± 0.5 to 6.4 ± 0.6 (P < 0.05) while placebo was ineffective (from 6.2 ± 0.5 to 6.3 ± 0.5).
2 context sentences(design, population, supporting numbers)
Summary · context
The main ingredients of AqualiefTM are carnosine and dried calyces of Hibiscus sabdariffa L. (karkadè) for their buffering effect at pH 7 as well as for their antioxidant, antimicrobial and lenitive properties.
Summary · context
In a Randomized, Placebo-Controlled, Double-Blind Trial, sixty patients with xerostomia (RTOG/EORTC grade 1-2) were randomly assigned to receive either placebo, or AqualiefTM tablets (three times/day after meals) for 6 consecutive days.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3261436101
02HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In patients with xerostomia, Aqualief increased stimulated saliva pH from 6.3 to 6.6.
In plain wordsIn patients with dry mouth, Aqualief increased stimulated saliva pH compared with baseline.
Peptide
L-carnosine
Outcome
IncreaseStimulated saliva pH
Study
n: not reported in source
Comparator
Baseline
Outcome group
Gastrointestinal function · Gastrointestinal
Measurements
stimulated saliva pH
6.3 pH
Aqualief group, day 0 (SD 0.5)
stimulated saliva pH
6.6 pH
Aqualief group, after 6 days (SD 0.5)
Source sentences
Summary
AqualiefTM also induced a significant increase in the pH of stimulated saliva from 6.3 ± 0.5 to 6.6 ± 0.5 (P < 0.01).
2 context sentences(design, population, supporting numbers)
Summary · context
The main ingredients of AqualiefTM are carnosine and dried calyces of Hibiscus sabdariffa L. (karkadè) for their buffering effect at pH 7 as well as for their antioxidant, antimicrobial and lenitive properties.
Summary · context
In a Randomized, Placebo-Controlled, Double-Blind Trial, sixty patients with xerostomia (RTOG/EORTC grade 1-2) were randomly assigned to receive either placebo, or AqualiefTM tablets (three times/day after meals) for 6 consecutive days.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3261436102
03HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In patients with xerostomia, saliva production rose by 56% from baseline with Aqualief and by 19% with placebo.
In plain wordsIn patients with dry mouth, saliva production rose with Aqualief and also rose with placebo.
Peptide
L-carnosine
Outcome
IncreaseSaliva production
Study
n: not reported in source
Comparator
Baseline; placebo also increased 19%
Outcome group
Gastrointestinal function · Gastrointestinal
Measurements
saliva production increase
56%
Aqualief group versus baseline, after 6 days
saliva production increase
19%
placebo group versus baseline
Source sentences
Summary
Besides an expected normalization of the saliva pH value, AqualiefTM treatment for 6 days greatly increased (56%, P < 0.0001) saliva production.
Summary
Placebo induced a 19% increase (P < 0.05), which was likely due to mechanical stimulation.
2 context sentences(design, population, supporting numbers)
Summary · context
The main ingredients of AqualiefTM are carnosine and dried calyces of Hibiscus sabdariffa L. (karkadè) for their buffering effect at pH 7 as well as for their antioxidant, antimicrobial and lenitive properties.
Summary · context
In a Randomized, Placebo-Controlled, Double-Blind Trial, sixty patients with xerostomia (RTOG/EORTC grade 1-2) were randomly assigned to receive either placebo, or AqualiefTM tablets (three times/day after meals) for 6 consecutive days.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3261436103
04HumanNot a test of L-carnosine aloneRandomized controlled trialEfficacy outcome
In patients with xerostomia, Aqualief increased stimulated saliva production by 27% compared with day 0.
In plain wordsIn patients with dry mouth, Aqualief increased stimulated saliva production compared with baseline.
Peptide
L-carnosine
Outcome
IncreaseStimulated saliva production
Study
n: not reported in source
Comparator
Baseline
Outcome group
Gastrointestinal function · Gastrointestinal
Measurements
stimulated saliva production increase
27%
Aqualief group versus day 0
Source sentences
Summary
AqualiefTM also increased stimulated saliva production (27% increase with respect to day 0, P < 0.05), while placebo was ineffective.
2 context sentences(design, population, supporting numbers)
Summary · context
The main ingredients of AqualiefTM are carnosine and dried calyces of Hibiscus sabdariffa L. (karkadè) for their buffering effect at pH 7 as well as for their antioxidant, antimicrobial and lenitive properties.
Summary · context
In a Randomized, Placebo-Controlled, Double-Blind Trial, sixty patients with xerostomia (RTOG/EORTC grade 1-2) were randomly assigned to receive either placebo, or AqualiefTM tablets (three times/day after meals) for 6 consecutive days.
In this study, L-carnosine was a lab tool or a carrier, part of a mix, or the subject of a lab method. This result is not evidence about taking L-carnosine.
Report a problemFND-3261436104

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

Version 2Current
27 Oct 2026, 18:20 UTC
Study results updated
Version 1
27 Oct 2026, 16:32 UTC
First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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