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Study · Animal study (in vivo) · mouse · 2020

8 results

HNG, A Humanin Analogue, Promotes Hair Growth by Inhibiting Anagen-to-Catagen Transition.

Kim SM, Kang JI, Yoon HS, Choi YK, Go JS, Oh SK, Ahn M, Kim J, Koh YS, Hyun JW, Yoo ES, Kang HK

International journal of molecular sciences26 Jun 2020Cited by 12 (Europe PMC)

PMID32604799 (opens in a new tab)PMCIDPMC7348781 (opens in a new tab)DOI10.3390/ijms21124553 (opens in a new tab)PepBankPUB-32604799
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Summary

The hair follicle goes through repetitive cycles including anagen, catagen, and telogen. The interaction of dermal papilla cells (DPCs) and keratinocytes regulates the hair cycle and hair growth. Humanin was discovered in the surviving brain cells of patients with Alzheimer's disease. HNG, a humanin analogue, activates cell growth, proliferation, and cell cycle progression, and it protects cells from apoptosis. This study was performed to investigate the promoting effect and action mechanisms of HNG on hair growth. HNG significantly increased DPC proliferation. HNG significantly increased hair shaft elongation in vibrissa hair follicle organ culture. In vivo experiment showed that HNG prolonged anagen duration and inhibited hair follicle cell apoptosis, indicating that HNG inhibited the transition from the anagen to catagen phase mice. Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs. This means that HNG could induce the anagen phase longer by up-regulating VEGF, which is a Stat3 target gene and one of the anagen maintenance factors. HNG stimulated the anagen phase longer with VEGF up-regulation, and it prevented apoptosis by activating Erk1/2, Akt, and Stat3 signaling.
CC BYText from Europe PMC. Highlighted sentences are the source of results.

Results from this study8

8 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice, HNG prolonged anagen duration.

    In plain wordsIn mice, HNG lengthened the growth phase of the hair cycle.

    Peptide
    Humanin
    Outcome
    IncreaseAnagen duration
    Study

    mousen: not reported in source

    mice, in vivo hair cycle
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo experiment showed that HNG prolonged anagen duration and inhibited hair follicle cell apoptosis, indicating that HNG inhibited the transition from the anagen to catagen phase mice.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice, HNG inhibited hair follicle cell apoptosis.

    In plain wordsIn mice, HNG reduced cell death in hair follicles.

    Peptide
    Humanin
    Outcome
    DecreaseHair follicle cell apoptosis
    Study

    mousen: not reported in source

    mice, in vivo hair cycle
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In vivo experiment showed that HNG prolonged anagen duration and inhibited hair follicle cell apoptosis, indicating that HNG inhibited the transition from the anagen to catagen phase mice.
  3. 03LabEx vivo tissueEfficacy outcome

    HNG significantly increased hair shaft elongation in vibrissa hair follicle organ culture.

    In plain wordsIn lab-grown hair follicles, HNG made hair shafts grow longer.

    Peptide
    Humanin
    Outcome
    IncreaseHair shaft elongation
    Study

    n: not reported in source

    vibrissa hair follicle organ culture
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG significantly increased hair shaft elongation in vibrissa hair follicle organ culture.
  4. 04LabIn vitro (cells)Efficacy outcome

    The humanin analogue HNG significantly increased dermal papilla cell proliferation.

    In plain wordsIn cells, the humanin analogue HNG increased growth of hair-follicle dermal papilla cells.

    Peptide
    Humanin
    Outcome
    IncreaseDermal papilla cell proliferation
    Study

    n: not reported in source

    dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HNG significantly increased DPC proliferation.
  5. 05LabIn vitro (cells)Mechanism

    HNG activated Erk1/2 within minutes in dermal papilla cells.

    In plain wordsIn cells, HNG switched on Erk1/2 signalling within minutes.

    Peptide
    Humanin
    Outcome
    IncreaseErk1/2 activation
    Study

    n: not reported in source

    dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs.
  6. 06LabIn vitro (cells)Mechanism

    HNG activated Akt within minutes in dermal papilla cells.

    In plain wordsIn cells, HNG switched on Akt signalling within minutes.

    Peptide
    Humanin
    Outcome
    IncreaseAkt activation
    Study

    n: not reported in source

    dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs.
  7. 07LabIn vitro (cells)Mechanism

    HNG activated Stat3 within minutes in dermal papilla cells.

    In plain wordsIn cells, HNG switched on Stat3 signalling within minutes.

    Peptide
    Humanin
    Outcome
    IncreaseStat3 activation
    Study

    n: not reported in source

    dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs.
  8. 08LabIn vitro (cells)Mechanism

    HNG up-regulated vascular endothelial growth factor levels in dermal papilla cells.

    In plain wordsIn cells, HNG raised levels of VEGF in hair-follicle dermal papilla cells.

    Peptide
    Humanin
    Outcome
    IncreaseVEGF levels
    Study

    n: not reported in source

    dermal papilla cells
    Outcome group
    Skin and hair · Skin and wound
    Studied dose
    Dose not stated

    Source sentences

    Summary
    Furthermore, HNG activated extracellular signal-regulated kinase (Erk)1/2, Akt, and signal transducer and activator of transcription (Stat3) within minutes and up-regulated vascular endothelial growth factor (VEGF) levels on DPCs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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