In male Wistar rats with hippocampal ischemia/reperfusion after bilateral carotid clamping, BPC‑157 counteracted both early and delayed neural hippocampal damage at 24 and 72 hr of reperfusion.
In plain wordsIn rats with a brief loss of brain blood flow, BPC‑157 reduced early and late damage to nerve cells in the hippocampus.
- Peptide
- BPC-157
- Outcome
- DecreaseEarly and delayed neural hippocampal damage
- Study
Male Wistar ratsn: not reported in source
Hippocampal ischemia/reperfusion after bilateral clamping of the common carotid arteries for 20 min- Comparator
- Saline
- Outcome group
- Neuroprotection · Nervous system and cognition
- Studied dose
- 10 µg/kg · 1 ml bath applied directly to the operated area (trigonum caroticum) · Applied 30 s after the 20-min clamping periodAs given in this study (Male Wistar rats).
Source sentences
In the operated rats, at 24 and 72 hr of the reperfusion, the therapy counteracted both early and delayed neural hippocampal damage, achieving full functional recovery (Morris water maze test, inclined beam-walking test, lateral push test).
1 context sentence(design, population, supporting numbers)
Male Wistar rats underwent bilateral clamping of the common carotid arteries for a 20-min period. At 30 s thereafter, we applied medication (BPC 157 10 µg/kg; or saline) as a 1 ml bath directly to the operated area, that is, trigonum caroticum.