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Study · In vitro (cells) · 2021

5 results

Humanin protects cortical neurons from calyculin A-induced neurotoxicities by increasing PP2A activity and SOD.

Zhao J, Zeng Y, Wang Y, Shi J, Zhao W, Wu B, Du H

The International journal of neuroscience22 May 2020Cited by 13 (Europe PMC)

PMID32408779 (opens in a new tab)DOI10.1080/00207454.2020.1769617 (opens in a new tab)PepBankPUB-32408779
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study5

5 results from studies that gave the peptide. No result from this study comes from people.

  1. 01LabIn vitro (cells)Activity measurement

    In cultured cortical neurons exposed to calyculin A, humanin preincubation preserved cell viability.

    In plain wordsIn cells, humanin added before calyculin A kept more cortical neurons alive.

    Peptide
    Humanin
    Outcome
    IncreaseCell viability after calyculin A
    Study

    n: not reported in source

    Cultured cortical neurons with calyculin A-induced neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN preincubation preserved cell viability
    2 context sentences
    Summary · context
    CA was added into the cultured cortical neurons to induce neurotoxicity.
    Summary · context
    Cortical neurons were preincubated with HN which plays a protective role.
  2. 02LabIn vitro (cells)Activity measurement

    In cultured cortical neurons exposed to calyculin A, humanin preincubation protected the neurons.

    In plain wordsIn cells, humanin added before calyculin A protected cortical neurons from damage.

    Peptide
    Humanin
    Outcome
    IncreaseNeuronal protection from calyculin A insults
    Study

    n: not reported in source

    Cultured cortical neurons with calyculin A-induced neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN preincubation preserved cell viability, protected the neurons, alleviated oxidative stress, and reserved PP2A activity.
    2 context sentences
    Summary · context
    CA was added into the cultured cortical neurons to induce neurotoxicity.
    Summary · context
    Cortical neurons were preincubated with HN which plays a protective role.
  3. 03LabIn vitro (cells)Mechanism

    In cultured cortical neurons exposed to calyculin A, humanin preincubation alleviated oxidative stress.

    In plain wordsIn cells, humanin added before calyculin A lowered oxidative stress in cortical neurons.

    Peptide
    Humanin
    Outcome
    DecreaseOxidative stress after calyculin A
    Study

    n: not reported in source

    Cultured cortical neurons with calyculin A-induced neurotoxicity
    Outcome group
    Oxidative stress · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN preincubation preserved cell viability, protected the neurons, alleviated oxidative stress, and reserved PP2A activity.
    2 context sentences
    Summary · context
    CA was added into the cultured cortical neurons to induce neurotoxicity.
    Summary · context
    Cortical neurons were preincubated with HN which plays a protective role.
  4. 04LabIn vitro (cells)Mechanism

    In cultured cortical neurons exposed to calyculin A, humanin preincubation preserved PP2A activity.

    In plain wordsIn cells, humanin added before calyculin A kept the activity of the enzyme PP2A.

    Peptide
    Humanin
    Outcome
    IncreasePP2A activity after calyculin A
    Study

    n: not reported in source

    Cultured cortical neurons with calyculin A-induced neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    HN preincubation preserved cell viability, protected the neurons, alleviated oxidative stress, and reserved PP2A activity.
    2 context sentences
    Summary · context
    CA was added into the cultured cortical neurons to induce neurotoxicity.
    Summary · context
    Cortical neurons were preincubated with HN which plays a protective role.
  5. 05LabIn vitro (cells)Mechanism

    In cultured cortical neurons exposed to calyculin A, humanin blocked tau overphosphorylation at Ser199/202, Ser396 and Thr231.

    In plain wordsIn cells, humanin blocked excess phosphate marks on the tau protein caused by calyculin A.

    Peptide
    Humanin
    Outcome
    DecreaseTau phosphorylation at Ser199/202, Ser396 and Thr231
    Study

    n: not reported in source

    Cultured cortical neurons with calyculin A-induced neurotoxicity
    Outcome group
    Neuroprotection · Nervous system and cognition
    Studied dose
    Dose not stated

    Source sentences

    Summary
    It also blocked tau overphosphorylation at Ser199/202, Ser396, and Thr231 sites and protected neurons against CA-induced insults.
    2 context sentences
    Summary · context
    CA was added into the cultured cortical neurons to induce neurotoxicity.
    Summary · context
    Cortical neurons were preincubated with HN which plays a protective role.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

Publication types

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