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Study · Animal study (in vivo) · mouse · 2020

7 results

Chronic exposure to low dose of bisphenol A causes follicular atresia by inhibiting kisspeptin neurons in anteroventral periventricular nucleus in female mice.

Tang C, Zhang J, Liu P, Zhou Y, Hu Q, Zhong Y, Wang X, Chen L

Neurotoxicology12 May 2020Cited by 19 (Europe PMC)

PMID32407858 (opens in a new tab)DOI10.1016/j.neuro.2020.04.011 (opens in a new tab)PepBankPUB-32407858
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

4 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In BPA-exposed female mice, intracerebroventricular kisspeptin‑10 reversed the decrease in serum LH.

    In plain wordsIn mice with BPA-induced hormone changes, kisspeptin‑10 given into the brain restored LH levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum LH after kisspeptin-10 in BPA mice
    Study

    mousen: not reported in source

    Adult female mice exposed to BPA (50 µg/kg, oral gavage, 60 days)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · i.c.v.As given in this study (mouse).

    Source sentences

    Summary
    In comparison with controls, the levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), hypothalamic gonadotrophin releasing hormone (GnRH) and the expression of kisspeptin in anteroventral periventricular nucleus (AVPV) decreased in BPA mice, which could be reversed by inject…
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In BPA-exposed female mice, intracerebroventricular kisspeptin‑10 reversed the decrease in serum FSH.

    In plain wordsIn mice with BPA-induced hormone changes, kisspeptin‑10 given into the brain restored FSH levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseSerum FSH after kisspeptin-10 in BPA mice
    Study

    mousen: not reported in source

    Adult female mice exposed to BPA (50 µg/kg, oral gavage, 60 days)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · i.c.v.As given in this study (mouse).

    Source sentences

    Summary
    In comparison with controls, the levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), hypothalamic gonadotrophin releasing hormone (GnRH) and the expression of kisspeptin in anteroventral periventricular nucleus (AVPV) decreased in BPA mice, which could be reversed by inject…
  3. 03AnimalAnimal study (in vivo)Efficacy outcome

    In BPA-exposed female mice, intracerebroventricular kisspeptin‑10 reversed the decrease in hypothalamic GnRH.

    In plain wordsIn mice with BPA-induced hormone changes, kisspeptin‑10 given into the brain restored GnRH levels.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseHypothalamic GnRH after kisspeptin-10 in BPA mice
    Study

    mousen: not reported in source

    Adult female mice exposed to BPA (50 µg/kg, oral gavage, 60 days)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated · i.c.v.As given in this study (mouse).

    Source sentences

    Summary
    In comparison with controls, the levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), hypothalamic gonadotrophin releasing hormone (GnRH) and the expression of kisspeptin in anteroventral periventricular nucleus (AVPV) decreased in BPA mice, which could be reversed by inject…
  4. 04AnimalAnimal study (in vivo)Efficacy outcome

    In BPA-exposed female mice, kisspeptin‑10 recovered the proestrus LH surge amplitude that BPA had decreased.

    In plain wordsIn mice with BPA-induced hormone changes, kisspeptin‑10 restored the LH surge that BPA had reduced.

    Peptide
    Kisspeptin-10
    Outcome
    IncreaseProestrus LH surge amplitude after kisspeptin-10 in BPA mice
    Study

    mousen: not reported in source

    Adult female mice exposed to BPA (50 µg/kg, oral gavage, 60 days)
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The amplitude of the proestrus LH surge decreased in mice exposed to BPA, but was recovered by administering kisspeptin-10.

Natural levels measured3

These results measure the body's own peptide. Nobody was given the peptide. They are not evidence about taking it. They are left out of key results, evidence counts and charts.

  1. 05AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In adult female mice, chronic BPA exposure decreased the body's own kisspeptin expression in the anteroventral periventricular nucleus compared with controls.

    In plain wordsIn mice, BPA exposure lowered the body's own kisspeptin in a brain region compared with controls.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseAVPV kisspeptin expression after BPA
    Study

    mousen: not reported in source

    Adult female mice exposed to BPA (50 µg/kg, oral gavage, 60 days)
    Comparator
    Control mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    In comparison with controls, the levels of serum luteinizing hormone (LH), follicle stimulating hormone (FSH), hypothalamic gonadotrophin releasing hormone (GnRH) and the expression of kisspeptin in anteroventral periventricular nucleus (AVPV) decreased in BPA mice, which could be reversed by inject…

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  2. 06AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In ovariectomized mice, BPA or the ERalpha antagonist MPP, but not the ERbeta antagonist PHTPP, inhibited estradiol-induced kisspeptin expression in the AVPV.

    In plain wordsIn mice, BPA and an estrogen receptor blocker lowered the body's own kisspeptin that estradiol normally raises in a brain region.

    Peptide
    Kisspeptin-10
    Outcome
    DecreaseE2-induced AVPV kisspeptin expression with BPA or MPP
    Study

    mousen: not reported in source

    Ovariectomized mice
    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Treatment with BPA or estrogen receptor α (ERα) antagonist MPP, but not ERβ antagonist PHTPP inhibited E2-induced AVPV-kisspeptin expression in ovariectomized mice.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

  3. 07AnimalEndogenous levelAnimal study (in vivo)Mechanism

    In mice, the ERalpha agonist PPT, but not the ERbeta agonist DPN, enhanced AVPV kisspeptin expression, and this enhanced expression decreased after BPA treatment.

    In plain wordsIn mice, an estrogen receptor activator raised the body's own kisspeptin in a brain region, and BPA lowered this rise.

    Peptide
    Kisspeptin-10
    Outcome
    MixedAVPV kisspeptin expression after ERalpha agonist PPT and BPA
    Study

    mousen: not reported in source

    Outcome group
    Sex hormones and fertility · Reproductive and sexual health

    Source sentences

    Summary
    Use of ERα agonist PPT rather than ERβ agonist DPN enhanced AVPV-kisspepetin expression, which decreased after treatment with BPA.

    This result measures the body's own Kisspeptin-10. Nobody was given the peptide. It is not evidence about taking it.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    10 Oct 2026, 09:43 UTC

    Study results updated

  2. Version 1

    9 Oct 2026, 03:04 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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