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Study · Animal study (in vivo) · mouse · 2020

7 results

Hexarelin targets neuroinflammatory pathways to preserve cardiac morphology and function in a mouse model of myocardial ischemia-reperfusion.

McDonald H, Peart J, Kurniawan ND, Galloway G, Royce SG, Samuel CS, Chen C

Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie8 May 2020Cited by 7 (Europe PMC)

PMID32403043 (opens in a new tab)DOI10.1016/j.biopha.2020.110165 (opens in a new tab)PepBankPUB-32403043
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: CC BY-NC-ND. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Efficacy outcome

    In mice with ischemia-reperfusion injury, hexarelin significantly improved left ventricular function versus vehicle.

    In plain wordsIn mice with heart injury, hexarelin improved heart pumping function compared with vehicle.

    Peptide
    Hexarelin
    Outcome
    IncreaseLeft ventricular function by MRI
    Study

    mousen: not reported in source

    Mouse myocardial ischemia-reperfusion (tLAD)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.3 mg/kg/day · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    IR-injured and sham mice were subjected to high-field magnetic resonance imaging to assess left ventricular (LV) function, with HEX-treated mice demonstrating a significant improvement in LV function compared with VEH-treated mice.
    1 context sentence
    Summary · context
    Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.
  2. 02AnimalAnimal study (in vivo)Efficacy outcome

    In mice with ischemia-reperfusion injury, hexarelin significantly decreased interstitial collagen after 21 days.

    In plain wordsIn mice with heart injury, hexarelin reduced scar-like collagen in the heart after 21 days.

    Peptide
    Hexarelin
    Outcome
    DecreaseInterstitial collagen
    Study

    mousen: not reported in source

    Mouse myocardial ischemia-reperfusion (tLAD)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.3 mg/kg/day · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    A significant decrease in interstitial collagen, TGF-β1 expression and myofibroblast differentiation was also seen in the HEX-treated mice after 21 days.
    1 context sentence
    Summary · context
    Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.
  3. 03AnimalAnimal study (in vivo)Mechanism

    In mice with ischemia-reperfusion injury, hexarelin significantly decreased TGF-β1 expression after 21 days.

    In plain wordsIn mice with heart injury, hexarelin lowered TGF-β1, a scarring signal, after 21 days.

    Peptide
    Hexarelin
    Outcome
    DecreaseTGF-β1 expression
    Study

    mousen: not reported in source

    Mouse myocardial ischemia-reperfusion (tLAD)
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    0.3 mg/kg/day · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    A significant decrease in interstitial collagen, TGF-β1 expression and myofibroblast differentiation was also seen in the HEX-treated mice after 21 days.
    1 context sentence
    Summary · context
    Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.
  4. 04AnimalAnimal study (in vivo)Mechanism

    In mice with ischemia-reperfusion injury, hexarelin significantly decreased myofibroblast differentiation after 21 days.

    In plain wordsIn mice with heart injury, hexarelin reduced formation of scar-forming cells after 21 days.

    Peptide
    Hexarelin
    Outcome
    DecreaseMyofibroblast differentiation
    Study

    mousen: not reported in source

    Mouse myocardial ischemia-reperfusion (tLAD)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.3 mg/kg/day · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    A significant decrease in interstitial collagen, TGF-β1 expression and myofibroblast differentiation was also seen in the HEX-treated mice after 21 days.
    1 context sentence
    Summary · context
    Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.
  5. 05AnimalAnimal study (in vivo)Mechanism

    In mice with ischemia-reperfusion injury, hexarelin shifted the autonomic nervous system balance towards parasympathetic predominance.

    In plain wordsIn mice with heart injury, hexarelin shifted nerve control of the heart towards the parasympathetic side.

    Peptide
    Hexarelin
    Outcome
    IncreaseAutonomic nervous system balance
    Study

    mousen: not reported in source

    Mouse myocardial ischemia-reperfusion (tLAD)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.3 mg/kg/day · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    HEX treatment shifted the ANS balance towards a parasympathetic predominance
    1 context sentence
    Summary · context
    Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.
  6. 06AnimalAnimal study (in vivo)Efficacy outcome

    In mice with ischemia-reperfusion injury, hexarelin significantly decreased cardiac troponin-I levels.

    In plain wordsIn mice with heart injury, hexarelin lowered troponin-I, a marker of heart muscle damage.

    Peptide
    Hexarelin
    Outcome
    DecreaseCardiac troponin-I level
    Study

    mousen: not reported in source

    Mouse myocardial ischemia-reperfusion (tLAD)
    Comparator
    Vehicle
    Outcome group
    Heart function · Cardiovascular
    Studied dose
    0.3 mg/kg/day · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    a significant decrease in cardiac troponin-I and TNF-α levels
    1 context sentence
    Summary · context
    Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.
  7. 07AnimalAnimal study (in vivo)Efficacy outcome

    In mice with ischemia-reperfusion injury, hexarelin significantly decreased TNF-α levels.

    In plain wordsIn mice with heart injury, hexarelin lowered TNF-α, an inflammation marker.

    Peptide
    Hexarelin
    Outcome
    DecreaseTNF-α level
    Study

    mousen: not reported in source

    Mouse myocardial ischemia-reperfusion (tLAD)
    Comparator
    Vehicle
    Outcome group
    Inflammation markers · Cardiovascular
    Studied dose
    0.3 mg/kg/day · 21 daysAs given in this study (mouse).

    Source sentences

    Summary
    a significant decrease in cardiac troponin-I and TNF-α levels
    1 context sentence
    Summary · context
    Myocardial ischemia was induced by transient ligation of the left descending coronary artery (tLAD) in C57BL/6 J mice followed by HEX (0.3 mg/kg/day; n = 20) or vehicle (VEH) (n = 18) administration for 21 days, first administered immediately prior-to reperfusion.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 2Current

    13 Oct 2026, 21:44 UTC

    Study results updated

  2. Version 1

    13 Oct 2026, 16:31 UTC

    First added · source update from Europe PMC

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