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Study · Animal study (in vivo) · dog, mouse and rat · 2020

7 results

Preclinical safety evaluation of body protective compound-157, a potential drug for treating various wounds.

Xu C, Sun L, Ren F, Huang P, Tian Z, Cui J, Zhang W, Wang S, Zhang K, He L, Zhang W, Zhang C and 4 more

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Hao Q, Zhang Y, Li M, Li W

Regulatory toxicology and pharmacology : RTP22 Apr 2020Cited by 41 (Europe PMC)

PMID32334036 (opens in a new tab)DOI10.1016/j.yrtph.2020.104665 (opens in a new tab)PepBankPUB-32334036
Publisher pagePubMedAsk about this study
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Summary

The text of this summary is not shown here, because the article license does not allow reuse. Read it at the source (opens in a new tab)

Text rights: Publisher copyright. Results still quote short attributed sentences.

Results from this study7

7 results from studies that gave the peptide. No result from this study comes from people.

  1. 01AnimalAnimal study (in vivo)Safety outcome

    In a preclinical study, the single-dose toxicity test of BPC157 showed no test-related effects.

    In plain wordsIn animal tests, a single dose of BPC157 caused no effects related to the test substance.

    Peptide
    BPC-157
    Outcome
    No significant changeSingle-dose toxicity
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    The single-dose toxicity study did not show any test-related effects that could be attributed to the test article.
    1 context sentence
    Summary · context
    This report presents preclinical toxicity studies with BPC157 in mice, rats, rabbits and dogs.
  2. 02AnimalAnimal study (in vivo)Safety outcome

    In dogs, repeated-dose BPC157 was well tolerated, with no abnormal changes between the BPC157 groups and the solvent control group, apart from a creatinine decrease at 2 mg/kg.

    In plain wordsIn dogs, repeated BPC157 doses were well tolerated compared with the solvent control, apart from one creatinine change at the highest dose.

    Peptide
    BPC-157
    Outcome
    No significant changeRepeated-dose toxicity in dogs, general tolerance
    Study

    dogn: not reported in source

    Comparator
    Solvent control
    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In repeated-dose toxicity evaluations, BPC157 was well tolerated in dogs, with no abnormal changes between the BPC157-treated groups and the solvent control group, with the exception of a decrease in creatinine level at a dose of 2 mg/kg but not at lower doses.
    1 context sentence
    Summary · context
    This report presents preclinical toxicity studies with BPC157 in mice, rats, rabbits and dogs.
  3. 03AnimalAnimal study (in vivo)Safety outcome

    In dogs, repeated-dose BPC157 decreased creatinine level at 2 mg/kg but not at lower doses; animals recovered spontaneously after 2 weeks of withdrawal.

    In plain wordsIn dogs, BPC157 lowered creatinine at 2 mg/kg but not at lower doses, and levels recovered after 2 weeks without the drug.

    Peptide
    BPC-157
    Outcome
    DecreaseCreatinine level in dogs, repeated dose
    Study

    dogn: not reported in source

    Comparator
    Solvent control
    Outcome group
    Adverse events · Whole body
    Studied dose
    2 mg/kgAs given in this study (dog).

    Measurements

    Dose with creatinine decrease
    2 mg/kg
    dogs

    Source sentences

    Summary
    In repeated-dose toxicity evaluations, BPC157 was well tolerated in dogs, with no abnormal changes between the BPC157-treated groups and the solvent control group, with the exception of a decrease in creatinine level at a dose of 2 mg/kg but not at lower doses.
    2 context sentences
    Summary · context
    The animals recovered spontaneously after 2 weeks of withdrawal.
    Summary · context
    This report presents preclinical toxicity studies with BPC157 in mice, rats, rabbits and dogs.
  4. 04AnimalAnimal study (in vivo)Safety outcome

    In a local tolerance test, irritation caused by BPC157 was mild.

    In plain wordsIn an animal local tolerance test, BPC157 caused only mild irritation.

    Peptide
    BPC-157
    Outcome
    Direction not reportedLocal tolerance (irritation)
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    A local tolerance test showed that the irritation caused by BPC157 was mild.
    1 context sentence
    Summary · context
    This report presents preclinical toxicity studies with BPC157 in mice, rats, rabbits and dogs.
  5. 05AnimalAnimal study (in vivo)Safety outcome

    BPC157 showed no genetic toxicity in preclinical testing.

    In plain wordsIn preclinical tests, BPC157 showed no gene damage.

    Peptide
    BPC-157
    Outcome
    No significant changeGenetic toxicity
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC157 also showed no genetic or embryo-fetal toxicity.
    1 context sentence
    Summary · context
    This report presents preclinical toxicity studies with BPC157 in mice, rats, rabbits and dogs.
  6. 06AnimalAnimal study (in vivo)Safety outcome

    BPC157 showed no embryo-fetal toxicity in preclinical testing.

    In plain wordsIn preclinical tests, BPC157 showed no harm to embryos or fetuses.

    Peptide
    BPC-157
    Outcome
    No significant changeEmbryo-fetal toxicity
    Study

    n: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    BPC157 also showed no genetic or embryo-fetal toxicity
    1 context sentence
    Summary · context
    This report presents preclinical toxicity studies with BPC157 in mice, rats, rabbits and dogs.
  7. 07AnimalAnimal study (in vivo)Safety outcome

    In mice, rats, rabbits and dogs, BPC157 was well tolerated and did not cause any serious toxicity.

    In plain wordsIn mice, rats, rabbits and dogs, BPC157 was well tolerated and caused no serious toxicity.

    Peptide
    BPC-157
    Outcome
    No significant changeOverall tolerability and serious toxicity in mice, rats, rabbits and dogs
    Study

    mouse, rat, rabbit, dogn: not reported in source

    Outcome group
    Adverse events · Whole body
    Studied dose
    Dose not stated

    Source sentences

    Summary
    In summary, BPC157 was well tolerated and did not cause any serious toxicity in mice, rats, rabbits and dogs.
    1 context sentence
    Summary · context
    This report presents preclinical toxicity studies with BPC157 in mice, rats, rabbits and dogs.

AI wrote and checked these results. AI can make mistakes, so check important results against the source.

Version history

PepBank keeps every version of the data on this study. Status changes from Retraction Watch, Europe PMC and Crossref are listed with their source.

  1. Version 3Current

    10 Oct 2026, 08:19 UTC

    Study results updated

  2. Version 2

    9 Oct 2026, 03:03 UTC

    Study data updated · source update from Europe PMC

  3. Version 1

    9 Oct 2026, 02:56 UTC

    First added · source update from Europe PMC

Subjects

Terms as the source lists them.

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